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Volumn 92, Issue 9, 1998, Pages 3057-3063

Reversal of lethal α- and β-thalassemias in mice by expression of human embryonic globins

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; DNA; EPSILON GLOBIN; GLOBIN; HEMOGLOBIN; UNCLASSIFIED DRUG; ZETA GLOBIN;

EID: 0032213386     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.9.3057.421k57_3057_3063     Document Type: Article
Times cited : (31)

References (44)
  • 1
    • 0001046939 scopus 로고
    • Molecular genetics of thalassemia
    • Verma RS (ed): Greenwich, CT, JAI
    • Russell JE, Liebhaber SA: Molecular genetics of thalassemia, in Verma RS (ed): Advances in Genome Biology, vol 2. Greenwich, CT, JAI, 1993, p 283
    • (1993) Advances in Genome Biology , vol.2 , pp. 283
    • Russell, J.E.1    Liebhaber, S.A.2
  • 4
    • 0024226611 scopus 로고
    • Distribution and control of some genetic disorders
    • Modell B, Bulyzhenkov: Distribution and control of some genetic disorders. World Health Stat Quart 41:209, 1988
    • (1988) World Health Stat Quart , vol.41 , pp. 209
    • Modell, B.1    Bulyzhenkov2
  • 5
    • 0032055871 scopus 로고    scopus 로고
    • Hydrops fetalis caused by alpha thalassemia: An emerging health care problem
    • Chui DHK, Waye JS: Hydrops fetalis caused by alpha thalassemia: An emerging health care problem. Blood 91:2213, 1998
    • (1998) Blood , vol.91 , pp. 2213
    • Chui, D.H.K.1    Waye, J.S.2
  • 7
    • 0028861997 scopus 로고
    • Chelation therapy in beta thalassemia: The benefits and limitations of desferrioxamine
    • Giardina PJ, Grady RW: Chelation therapy in beta thalassemia: The benefits and limitations of desferrioxamine. Semin Hematol 32:310, 1995
    • (1995) Semin Hematol , vol.32 , pp. 310
    • Giardina, P.J.1    Grady, R.W.2
  • 10
    • 0026666314 scopus 로고
    • Developmental switching of messenger RNA expression from the human alpha-globin cluster: Fetal/adult pattern of theta globin gene expression
    • Albitar M, Care A, Peschle C, Liebhaber SA: Developmental switching of messenger RNA expression from the human alpha-globin cluster: Fetal/adult pattern of theta globin gene expression. Blood 80:1586, 1992
    • (1992) Blood , vol.80 , pp. 1586
    • Albitar, M.1    Care, A.2    Peschle, C.3    Liebhaber, S.A.4
  • 12
    • 0007103565 scopus 로고
    • Increased Hb F in adult life
    • Higgs DR, Weatherall DJ (eds): London, UK, Balliere Tindall
    • Wood WG: Increased Hb F in adult life, in Higgs DR, Weatherall DJ (eds): The Hemoglobinopathies. London, UK, Balliere Tindall, 1993
    • (1993) The Hemoglobinopathies
    • Wood, W.G.1
  • 13
    • 0028204237 scopus 로고
    • Production of human embryonic hemoglobin (Gower-II) in a yeast expression system
    • Mould RM, Hofmann OM, Brittain T: Production of human embryonic hemoglobin (Gower-II) in a yeast expression system. Biochem J 298:619, 1994
    • (1994) Biochem J , vol.298 , pp. 619
    • Mould, R.M.1    Hofmann, O.M.2    Brittain, T.3
  • 14
    • 0028909845 scopus 로고
    • Allosteric modulation of oxygen binding to the three human embryonic hemoglobins
    • Hofmann OM, Mould R, Brittain T: Allosteric modulation of oxygen binding to the three human embryonic hemoglobins. Biochem J 306:367, 1995
    • (1995) Biochem J , vol.306 , pp. 367
    • Hofmann, O.M.1    Mould, R.2    Brittain, T.3
  • 15
    • 0014559752 scopus 로고
    • Erythrocytosis associated with hemoglobin Ranier: Oxygen equilibria and marrow regulation
    • Adamson JW, Parer JT, Stamatoyannopoulous G: Erythrocytosis associated with hemoglobin Ranier: Oxygen equilibria and marrow regulation. J Clin Invest 48:1376, 1969
    • (1969) J Clin Invest , vol.48 , pp. 1376
    • Adamson, J.W.1    Parer, J.T.2    Stamatoyannopoulous, G.3
  • 17
    • 0027049543 scopus 로고
    • Oxygen-binding properties and mechanical stability of human hemoglobin made in yeast
    • Adachi K, Konitzer P, Lai CH, Kim J, Surrey S: Oxygen-binding properties and mechanical stability of human hemoglobin made in yeast. Protein Eng 5:807, 1992
    • (1992) Protein Eng , vol.5 , pp. 807
    • Adachi, K.1    Konitzer, P.2    Lai, C.H.3    Kim, J.4    Surrey, S.5
  • 18
    • 0030003151 scopus 로고    scopus 로고
    • Developmental silencing of the embryonic zeta-globin gene: Concerted action of the promoter and the 3′ flanking region combined with stage-specific silencing of the transcribed region
    • Liebhaber SA, Wang Z, Cash F, Monks B, Russell JE: Developmental silencing of the embryonic zeta-globin gene: Concerted action of the promoter and the 3′ flanking region combined with stage-specific silencing of the transcribed region. Mol Cell Biol 16:2637, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 2637
    • Liebhaber, S.A.1    Wang, Z.2    Cash, F.3    Monks, B.4    Russell, J.E.5
  • 19
    • 0030006957 scopus 로고    scopus 로고
    • The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region
    • Russell JE, Liebhaber SA: The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region. Blood 87:5314, 1996
    • (1996) Blood , vol.87 , pp. 5314
    • Russell, J.E.1    Liebhaber, S.A.2
  • 20
    • 0023442125 scopus 로고
    • A 3′ enhancer contributes to the stage-specific expression of the human beta-globin gene
    • Trudel M, Constantini F: A 3′ enhancer contributes to the stage-specific expression of the human beta-globin gene. Genes Dev 1:954, 1987
    • (1987) Genes Dev , vol.1 , pp. 954
    • Trudel, M.1    Constantini, F.2
  • 21
    • 0024506821 scopus 로고
    • A dominant control region from human beta-globin locus conferring integration site-independent gene expression
    • Talbot D, Collis P, Antoniou M, Vidal M, Grosveld F, Greaves DR: A dominant control region from human beta-globin locus conferring integration site-independent gene expression. Nature 33:352, 1989
    • (1989) Nature , vol.33 , pp. 352
    • Talbot, D.1    Collis, P.2    Antoniou, M.3    Vidal, M.4    Grosveld, F.5    Greaves, D.R.6
  • 23
    • 0029841814 scopus 로고    scopus 로고
    • Inactivation of mouse alpha-globin gene by homologous recombination: Mouse model of hemoglobin H disease
    • Chang J, Lu RH, Xu SM, Meneses J, Chan K, Pederson R, Kan YW: Inactivation of mouse alpha-globin gene by homologous recombination: Mouse model of hemoglobin H disease. Blood 88:1846, 1996
    • (1996) Blood , vol.88 , pp. 1846
    • Chang, J.1    Lu, R.H.2    Xu, S.M.3    Meneses, J.4    Chan, K.5    Pederson, R.6    Kan, Y.W.7
  • 24
    • 0027938450 scopus 로고
    • Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy
    • Detloff PJ, Lewis J, John SWM, Shehee WR, Langenbach R, Maeda N, Smithies O: Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Mol Cell Biol 14:6936, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 6936
    • Detloff, P.J.1    Lewis, J.2    John, S.W.M.3    Shehee, W.R.4    Langenbach, R.5    Maeda, N.6    Smithies, O.7
  • 26
    • 0029045603 scopus 로고
    • Mouse model of human beta(o) thalassemia: Targeted deletion of the mouse beta maj- And beta min-globin genes in embryonic stem cells
    • Ciavatta DJ, Ryan TM, Farmer SC, Townes TM: Mouse model of human beta(o) thalassemia: Targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci USA 92:9259, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9259
    • Ciavatta, D.J.1    Ryan, T.M.2    Farmer, S.C.3    Townes, T.M.4
  • 27
    • 0018189174 scopus 로고
    • Resolution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100
    • Rovera G, Magarian C, Borun TW: Resolution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100. Anal Biochem 85:506, 1978
    • (1978) Anal Biochem , vol.85 , pp. 506
    • Rovera, G.1    Magarian, C.2    Borun, T.W.3
  • 28
    • 0019345637 scopus 로고
    • Gel electrophoretic separation of globin chains
    • Alter BP: Gel electrophoretic separation of globin chains. Prog Clin Biol Res 60:157, 1981
    • (1981) Prog Clin Biol Res , vol.60 , pp. 157
    • Alter, B.P.1
  • 29
    • 0004155427 scopus 로고
    • New York, NY, Freeman
    • Stryer L: Biochemistry. New York, NY, Freeman, 1993, p 157
    • (1993) Biochemistry , pp. 157
    • Stryer, L.1
  • 30
    • 0026441126 scopus 로고
    • The mouse beta-globin locus control region: Hypersensitive sites 3 and 4
    • Jimenez G, Gale KB, Enver T: The mouse beta-globin locus control region: hypersensitive sites 3 and 4. Nucleic Acids Res 20:5797, 1992
    • (1992) Nucleic Acids Res , vol.20 , pp. 5797
    • Jimenez, G.1    Gale, K.B.2    Enver, T.3
  • 31
    • 0026453360 scopus 로고
    • Structure and function of the murine beta-globin locus control region 5′ HS-3
    • Hug B, Moon AM, Ley TJ: Structure and function of the murine beta-globin locus control region 5′ HS-3. Nucleic Acids Res 20:5771, 1992
    • (1992) Nucleic Acids Res , vol.20 , pp. 5771
    • Hug, B.1    Moon, A.M.2    Ley, T.J.3
  • 32
    • 0028178622 scopus 로고
    • Localization and characterization of the mouse alpha-globin locus control region
    • Kielman MF, Smits R, Bernini LF: Localization and characterization of the mouse alpha-globin locus control region. Genomics 21:431, 1994
    • (1994) Genomics , vol.21 , pp. 431
    • Kielman, M.F.1    Smits, R.2    Bernini, L.F.3
  • 33
    • 0027944303 scopus 로고
    • Analysis of the developmental and transcriptional potentiation functions of 5′ HS-2 of the murine beta-globin locus control region in transgenic mice
    • Enver T, Li Q, Gale KB, Hu M, May GE, Karlinsey JE, Jiminez G, Papayannopoulou T, Constantini F: Analysis of the developmental and transcriptional potentiation functions of 5′ HS-2 of the murine beta-globin locus control region in transgenic mice. Dev Biol 165:574, 1994
    • (1994) Dev Biol , vol.165 , pp. 574
    • Enver, T.1    Li, Q.2    Gale, K.B.3    Hu, M.4    May, G.E.5    Karlinsey, J.E.6    Jiminez, G.7    Papayannopoulou, T.8    Constantini, F.9
  • 34
    • 0026610223 scopus 로고
    • Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice
    • Raich N, Papayannopoulou T, Stamatoyannopoulous G, Enver T: Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice. Blood 79:861, 1992
    • (1992) Blood , vol.79 , pp. 861
    • Raich, N.1    Papayannopoulou, T.2    Stamatoyannopoulous, G.3    Enver, T.4
  • 35
    • 0027422976 scopus 로고
    • Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- And stage-specifie elements
    • Trepicchio WL, Dyer MA, Baron MH: Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specifie elements. Mol Cell Biol 13:7457, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 7457
    • Trepicchio, W.L.1    Dyer, M.A.2    Baron, M.H.3
  • 37
    • 3643092391 scopus 로고
    • Identification of a major positive regulatory element located 5′ to the human zeta-globin gene
    • Sabeth DE, Koehler KM, Yang WQ, Patton K, Stamatoyannopou lous G: Identification of a major positive regulatory element located 5′ to the human zeta-globin gene. Blood 82:2899, 1995
    • (1995) Blood , vol.82 , pp. 2899
    • De Sabeth1    Koehler, K.M.2    Yang, W.Q.3    Patton, K.4    Stamatoyannopou Lous, G.5
  • 38
    • 0030444615 scopus 로고    scopus 로고
    • Structure and function of the zeta-globin upstream regulatory element
    • Sabath DE, Koehler KM, Yang WQ: Structure and function of the zeta-globin upstream regulatory element. Nucleic Acids Res 24: 4978, 1996
    • (1996) Nucleic Acids Res , vol.24 , pp. 4978
    • Sabath, D.E.1    Koehler, K.M.2    Yang, W.Q.3
  • 39
    • 0031947553 scopus 로고    scopus 로고
    • Sequence divergence in the 3′UTRs of human zeta- And alpha-globin mRNA mediates a difference in their stabilities and contributes to efficient zeta-to-alpha gene developmental switching
    • Russell JE, Morales J, Makeyev A, Liebhaber SA: Sequence divergence in the 3′UTRs of human zeta- and alpha-globin mRNA mediates a difference in their stabilities and contributes to efficient zeta-to-alpha gene developmental switching. Mol Cell Biol 18:2173, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 2173
    • Russell, J.E.1    Morales, J.2    Makeyev, A.3    Liebhaber, S.A.4
  • 43
    • 0025169059 scopus 로고
    • Develop mentally regulated and erythroid-specific expression of the human beta-globin gene in transgenic mice
    • Shih DM, Wall RJ, Shapiro SG: Develop mentally regulated and erythroid-specific expression of the human beta-globin gene in transgenic mice. Nucleic Acids Res 18:5465, 1991
    • (1991) Nucleic Acids Res , vol.18 , pp. 5465
    • Shih, D.M.1    Wall, R.J.2    Shapiro, S.G.3
  • 44
    • 0030786622 scopus 로고    scopus 로고
    • Mouse zeta- And alpha-globin genes: Embryonic survival, alpha thalassemia, and genetic background effects
    • Leder A, Daugherty C, Whitney B, Leder P: Mouse zeta- and alpha-globin genes: embryonic survival, alpha thalassemia, and genetic background effects. Blood 90:1275, 1997
    • (1997) Blood , vol.90 , pp. 1275
    • Leder, A.1    Daugherty, C.2    Whitney, B.3    Leder, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.