Developmental silencing of the embryonic ζ-globin gene: Concerted action of the promoter and the 3′-flanking region combined with stage-specific silencing by the transcribed segment

Molecular and Cellular Biology

Volumn 16, Issue 6, 1996, Pages 2637-2646

  Liebhaber, Stephen A ^a,b   Wang, Zhibin ^a   Cash, Faith E ^a   Monks, Bob ^a   Russell, J Eric ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Clinical Research Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBIN;

ARTICLE; EMBRYO DEVELOPMENT; GENE CLUSTER; GENE CONTROL; GENE SWITCHING; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; BONE MARROW; CELL MOVEMENT; EMBRYONIC AND FETAL DEVELOPMENT; ERYTHROBLASTS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, SWITCH; GLOBINS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MODELS, GENETIC; PREGNANCY; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC; YOLK SAC;

EUKARYOTA;

EID: 0030003151     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.16.6.2637     Document Type: Article

References (52)

1. Albitar, M., A. Care, C. Peschle, and S. A. Liebhaber. 1992. Developmental switching of messenger RNA expression from human α-globin cluster: fetal/adult pattern of theta-globin gene expression. Blood 80:1586-1591.
2. Albitar, M., F. E. Cash, C. Peschle, and S. A. Liebhaber. 1992. Developmental switch in the relative expression of the α1-and α2-globin genes in humans and in transgenic mice. Blood 79:2471-2474.
3. Albitar, M., M. Katsumata. and S. A. Liebhaber. 1991. Human α-globin genes demonstrate autonomous developmental regulation in transgenic mice. Mol. Cell. Biol. 11:3786-3794.
4. Bunn, H. F., and B. G. Forget. 1977. Hemoglobin: molecular, genetic and clinical aspects. The W. B. Saunders Company, Philadelphia.
5. Dillon, N., and F. Grosveld. 1993. Transcriptional regulation of multigene loci: multilevel control. Trends Genet. 9:134-137.
6. Engel, J. D. 1993. Developmental regulation of human β-globin gene transcription: a switch of loyalties? Trends Genet. 9:304-309.
7. Goodman, M., J. Czelusniak, B. F. Koop, D. A. Tagle, and J. L. Slightom. 1987. Globins: a case study in molecular phylogeny. Cold Spring Harbor Symp. Quant. Biol. 52:875-880.
8. Gourdon, G., J. Sharpe, D. Wells, W. Wood, and D. Higgs. 1994. Analysis of a 70kb segment of DNA containing the human ζ- and α-globin genes linked to their regulatory element (HS-40) in transgenic mice. Nucleic Acids Res. 22:4139-4147.
9. Hanscombe, O., M. Vidal, J. Kaeda, L. Luzzatto, D. R. Greaves, and F. Grosveld. 1989. High-level, erythroid-specific expression of the human α-globin in transgenic mice and the production of human hemoglobin in murine erythrocytes. Genes Dev. 3:1572-1581.
10. Higgs, D. R., M. A. Vickers, A. O. Wilkie, I. M. Pretorius, A. P. Jarman, and D. J. Weatherall. 1989. A review of the molecular genetics of the human α-globin gene cluster. Blood 73:1081-1104.
11. Higgs, D. R., W. G. Wood, A. P. Jarman, J. Sharpe, J. Lida, I. M. Pretorius, and H. Ayyub. 1990. A major positive regulatory region located far upstream of the human α-globin gene locus. Genes Dev. 4:1588-1601.
12. Huehns, E. R., N. Dance, G. H. Beaven, J. V. Keil, R. Hecht, and A. Motulsky. 1964. Human embryonic hemoglobin. Cold Spring Harbor Symp. Quant. Biol. 21:327-330.
13. Kiledjian, M., X. Wang, and S. A. Liebhaber. 1995. Identification of two KH domain proteins in the α-globin mRNP stability complex. EMBO J. 14:4357-4364.
14. Lau, Y. F., and Y. W. Kan. 1983. Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with human α-globin gene cluster. Proc. Natl. Acad. Sci. USA 80:5225-5228.
15. Lauer, J., C. K. Shen, and T. Maniatis. 1980. The chromosomal arrangement of human α-like globin genes: sequence homology and α-globin gene deletions. Cell 20:119-130.
16. Leder, A., A. Kuo, M. Shen, and P. Leder. 1992 In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors. Development 116:1041-1049.
17. Leder, A., D. Swan, R. Ruddle, P. D'Eustachio, and P. Leder. 1981. Dispersion of α-like globin genes of the mouse to three different chromosomes. Nature (London) 293:196-200.
18. Leder, A., L. Weir, and P. Leder. 1985. Characterization, expression, and evolution of the mouse embryonic ζ-globin gene. Mol. Cell. Biol. 5:1025-1033.
19. Ley, T. J., K. A. Maloney, J. I. Gordon, and A. L. Schwartz. 1989. Globin gene expression in erythroid human fetal liver cells. J. Clin. Invest. 83:1032-1038.
20. Liebhaber, S. A. 1989. α-Thalassemia: a review. Hemoglobin 13:685-731.
21. Liebhaber, S. A., F. E. Cash, and S. K. Ballas. 1986. Human α-globin gene expression: the dominant role of the α2-locus in mRNA and proteins synthesis. J. Biol. Chem. 261:15327-15333.
22. Liebhaber, S. A., M. Goossens, and Y. W. Kan. 1981. Homologus and concerted evolution at the α1- and α2-loci of human α-globin. Nature (London) 290:26-29.
23. Liebhaber, S. A., and Y. W. Kan. 1981. Differentiation of the mRNA transcripts originating from the α1- and α2-globin loci in normals and α-thalassemics. J. Clin. Invest. 68:439-446.
24. Liebhaber, S. A., X. Wang, M. Kiledjian, and I. M. Weiss. 1995. Cis and trans control of globin mRNA stability, p. 375-391. In G. Stamatoyannopoulos (ed.), Proceedings of the 9th Conference on Hemoglobin Switching. Alan R. Liss, Inc., New York.
25. Modell, B., and V. Bulyzhenkov. 1988. Distribution and control of some genetic disorders. World Health Stat. Q. 41:209-218.
26. Moore, M. A., and E. Metclaf. 1970. Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br. J. Haematol. 18:279-296.
27. Peschle, C., F. Mavilio, A. Care, G. Migliaccio, A. R. Migliaccio, G. Salvo, P. Samoggia, S. Petti, R. Guerriero, M. Marinucci, D. Lazzaro, G. Russo, and G. Mastroberardino. 1985. Haemoglobin switching in human embryos; asynchrony of ζ→α and ε→γ-globin switches in primitive and definitive eythropoietic lineage. Nature (London) 313:235-238.
28. Pondel, M. D., N. J. Proudfoot, C. Whitelaw, and E. Whitelaw. 1992. The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene. Nucleic Acids Res. 20:5655-5660.
29. Pressley, L., D. R. Higgs, J. B. Clegg, and D. J. Weatherall. 1980. Gene deletions in α thalassemia prove that the 5′ ζ-locus is functional. Proc. Natl. Acad. Sci. USA 77:3586-3589.
30. Purohit, K., and A. Deisseroth. 1987. DNAse I nuclease digestion studies of the human zeta globin gene before and after transfer from the K562 cell to the mouse erythroleukemia cell, p. 295-302. In G. Stamatoyannopoulos and A. Nienhuis (ed.), Developmental control of globin gene expression. Alan R. Liss, Inc., New York.
31. Raich, N., C. H. Clegg, J. Grofti, P. H. Romeo, and G. Stamatoyannopoulos. 1995. GATA1 and YY1 are developmental repressors of the human ε-globin gene. EMBO J. 14:801-809.
32. Raich, N., T. Enver, B. Nakamoto, T. Josephson, T. Papayannopoulou, and G. Stamatoyannopoulos. 1990. Autonomous developmental control of human embryonic globin gene switching in transgenic mice. Science 250:1147-1149.
33. Russell, E. S. 1979. Hereditary anemias of the mouse: a review for geneticists. Adv. Genet. 20:357-459.
34. Russell, J. E., Z. Wang, B. Monks, F. Cash, and S. A. Liebhaber. 1994. Post-transcriptional component to silencing of the human ζ-globin gene. Blood 84:506a.
35. Sabath, D. E., K. M. Koehler, W. Q. Yang, K. Patton, and G. Stamatoyannopoulos. 1995. Identification of a major positive regulatory element located 5′ to the human ζ-globin gene. Blood 85:2587-2597.
36. Sabath, D. E., E. A. Spangler, E. M. Rubin, and G. Stamatoyannopoulos. 1993. Analysis of the human ζ-globin gene promoter in transgenic mice. Blood 82:2899-2905.
37. Sharpe, J. A., D. J. Wells, E. Whitelaw, P. Vyas, D. R. Higgs, and W. G. Wood. 1993. Analysis of the human α-globin gene cluster in transgenic mice. Proc. Nail. Acad. Sci. USA 90:11262-11266.
38. Shin, D. M., R. J. Wall, and S. G. Shapiro. 1990. Developmentally regulated and erythroid-specific expression of the human embronic β-globin gene in transgenic mice. Nucleic Acids Res. 18:5465-5472.
39. Spangler, E. A., K. A. Andrews, and E. M. Rubin. 1991. Developmental regulation of the human zeta globin gene in transgenic mice. Nucleic Acids Res. 18:7093-7097.
40. Stamatoyannopoulos, G., and A. Nienhuis. 1987. Hemoglobin switching, p. 66-105. In G. Stamatoyannopoulos, A. W. Nienhuis, P. Leder, and P. W. Majerus (ed.), The molecular basis of blood diseases. The W. B. Saunders Company, Philadelphia.
41. Talbot, D., P. Collis, M. Antoniou, M. Vidal, F. Grosveld, and D. R. Greaves. 1989. A dominant control region from human β-globin locus conferring integration site-independent gene expression. Nature (London) 33:352-355.
42. Tang, W., H. Y. Luo, M. Albitar, M. Patterson, B. Eng, J. S. Waye, S. A. Liebhaber, D. R. Higgs, and D. H. K. Chui. 1992. Human embryonic ζ-glohin chain expression in deletional α-thalassemia. Blood 80:517-522.
43. Vogelstein, B., and D. Giilespie. 1979. Preparative and analytical purification of DNA from agarose. Proc. Natl. Acad. Sci. USA 76:615-619.
44. Vyas, P., J. Sharpe, P. Watt, D. R. Higgs, and W. Wood. 1992. Regulation of human embryonic globin genes ζ2 and ε in stably transformed mouse erythroleukemia cells. Blood 80:1832-1837.
45. Vyas, P. A., M. A. Vickers, D. L. Simmons, H. Ayyub, C. R. Craddock, and D. R. Higgs. 1992. Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin. Cell 69:781-793.
46. Wang, X., M. Kiledjian, I. M. Weiss, and S. A. Liebhaber. 1994. Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol. Cell. Biol. 15:1769-1777.
47. 46a.Wang, X., and S. A. Liebhaber. Unpublished data.
48. Weiss, I. M., and S. A. Liebhaber. 1994. Erythroid cell-specific determinants of α-globin mRNA stability. Mol. Cell. Biol. 14:8123-8132.
49. Weiss, I. M., and S. A. Liebhaber. 1995. Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region. Mol. Cell. Biol. 15:2457-2465.
50. Whitelaw, E., P. Lamb, P. Hogben, and N. J. Proudfoot. 1989. The globin switch at the level of mRNA in the developing mouse, p. 323-333. In G. Stamatoyannopoulos and A. Nienhuis (ed.). Hemoglobin switching, part A. Transcriptional regulation. Alan R. Liss, Inc., New York.
51. Wong, P. M., S. W. Chung, S. M. Reicheld, and D. H. Chui. 1985. Ontogeny of the mouse hematopoietic system. Prog. Clin. Biol. Res. 193:17-28.
52. Yagi, M., R. Gelinas, J. T. Elder, M. Peretz, T. Papayannopoulou, G. Stamatoyannopoulos, and M. Groudine. 1986. Chromatin structure and developmental expression of the human α-globin cluster. Mol. Cell. Biol. 6:1108-1116.