A human norovirus-like particle vaccine adjuvanted with ISCOM or mLT induces cytokine and antibody responses and protection to the homologous GII.4 human norovirus in a gnotobiotic pig disease model

Vaccine

Volumn 25, Issue 50, 2007, Pages 8448-8459

  Souza, Menira ^a   Costantini, Veronica ^a   Azevedo, Marli S P ^a   Saif, Linda J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Calicivirus; Gnotobiotic pig model; Immunity; Norovirus; Vaccine; VLP

Indexed keywords

BACTERIAL TOXIN; ESCHERICHIA COLI HEAT LABILE TOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; ISCOM; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DIARRHEA; DRUG MECHANISM; ESCHERICHIA COLI; GNOTOBIOTICS; IMMUNE RESPONSE; INTESTINE; NONHUMAN; NOROVIRUS; PHENOTYPE; PRIORITY JOURNAL; SEROCONVERSION; SWINE; TH1 CELL; TH2 CELL; VIRUS INFECTION; VIRUS LIKE AGENT; VIRUS SHEDDING; VIRUS STRAIN;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, VIRAL; BACTERIAL TOXINS; CALICIVIRIDAE INFECTIONS; CYTOKINES; DISEASE MODELS, ANIMAL; ENTEROTOXINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GERM-FREE LIFE; HUMANS; IMMUNIZATION; IMMUNIZATION, SECONDARY; ISCOMS; MUTATION; NOROVIRUS; SWINE; TH1 CELLS; TH2 CELLS; VIRAL VACCINES; VIRION;

EID: 36248961689     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.09.040     Document Type: Article

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