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Volumn 20, Issue 7-8, 2002, Pages 1019-1029

Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccine

Author keywords

Influenza; Mucosal adjuvant; Oral vaccination

Indexed keywords

ADJUVANT; CD4 ANTIGEN; CYTOKINE; ESCHERICHIA COLI ENTEROTOXIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INACTIVATED VACCINE; INFLUENZA VACCINE;

EID: 0037081541     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00452-2     Document Type: Article
Times cited : (42)

References (73)
  • 1
    • 0035918179 scopus 로고    scopus 로고
    • Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • (2001) MMWR , vol.50 , pp. 1-44
  • 3
    • 0022658480 scopus 로고
    • Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine
    • (1986) J Clin Microbiol , vol.23 , pp. 66-72
    • Clements, M.L.1    Murphy, B.R.2
  • 8
    • 0033913482 scopus 로고    scopus 로고
    • Efficacy of vaccination with live attenuated, cold-adapted, trivalent intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine
    • (2000) J Pediatr , vol.136 , pp. 168-175
    • Belshe, R.B.1    Gruber, W.C.2    Mendelman, P.M.3
  • 20
    • 0026458260 scopus 로고
    • Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin
    • (1992) Microbiol Rev , vol.56 , pp. 622-647
    • Spangler, B.D.1
  • 25
    • 0032489830 scopus 로고    scopus 로고
    • Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity
    • (1998) J Exp Med , vol.187 , Issue.7 , pp. 1123-1132
    • Giuliani, M.M.1    Del Giudice, G.2    Giannelli, V.3
  • 30
    • 0026699224 scopus 로고
    • The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity
    • (1992) Eur J Immunol , vol.22 , pp. 2277-2281
    • Lycke, N.1    Tsuji, T.2    Holmgren, J.3
  • 33
    • 0031900149 scopus 로고    scopus 로고
    • Rotavirus 2/6 virus like particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge
    • (1998) J Virol , vol.72 , Issue.4 , pp. 3390-3393
    • O'Neal, C.M.1    Clements, J.D.2    Estes, M.K.3    Conner, M.E.4
  • 35
    • 0033799021 scopus 로고    scopus 로고
    • Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs
    • (2000) J Virol , vol.74 , pp. 8843-8853
    • Yuan, L.1    Geyer, A.2    Hodgins, D.C.3
  • 36
    • 0035027908 scopus 로고    scopus 로고
    • Human papillomavirus virus-like particles are efficient oral immunogens when coadministered with Escherichia coli heat-labile enterotoxin mutant R192G or CpG DNA
    • (2001) J Virol , vol.75 , pp. 4752-4760
    • Gerber, S.1    Lane, C.2    Brown, D.M.3
  • 38
    • 0032054708 scopus 로고    scopus 로고
    • LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.
    • (1998) Vaccine , vol.16 , Issue.7 , pp. 732-740
    • Chong, C.1    Friberg, M.2    Clements, J.D.3
  • 42
    • 0032769773 scopus 로고    scopus 로고
    • Intranasal immunization of mice with influenza vaccine in combination with the adjuvant LT-R72 induces potent mucosal and serum immunity which is stronger than that with traditional intramuscular immunization
    • (1999) Infect Immun , vol.67 , Issue.8 , pp. 4276-4279
    • Barackman, J.D.1    Ott, G.2    O'Hagan, D.T.3
  • 44
    • 0035961457 scopus 로고    scopus 로고
    • Effectiveness and safety of mutant Escherichia coli heat-labile enterotoxin (LT H44A) as an adjuvant for nasal influenza vaccine
    • (2001) Vaccine , vol.19 , pp. 2071-2079
    • Hagiwara, Y.1    Tsuji, T.2    Iwasaki, T.3
  • 46
    • 0023760366 scopus 로고
    • Induction, persistence and strain specificity of haemagglutinin-specific secretory antibodies in lungs of mice after intragastric administration of inactivated influenza virus vaccines
    • (1988) J Gen Virol , vol.69 , Issue.6 , pp. 2779-2784
    • Chen, K.S.1    Quinnan Jr., G.V.2
  • 50
    • 0021340306 scopus 로고
    • Genetic stability of A/Ann Arbor/6/60 cold-mutant (temperature-sensitive) live influenza virus genes: Analysis by oligonucleotide mapping or recombinant vaccine strains before and after replication in volunteers
    • (1984) J Infect Dis , vol.149 , pp. 194-200
    • Cox, N.J.1    Kendal, A.P.2
  • 52
    • 0034008623 scopus 로고    scopus 로고
    • A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged mice
    • (2000) Vaccine , vol.18 , pp. 2177-2187
    • Katz, J.M.1    Lu, X.H.2    Todd, C.W.3    Newman, M.J.4
  • 56
    • 0032728547 scopus 로고    scopus 로고
    • Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: Differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells
    • (1999) Infect Immun , vol.67 , pp. 6270-6280
    • Ryan, E.J.1    McNeela, E.2    Murphy, G.A.3
  • 60
    • 0027183310 scopus 로고
    • Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
    • (1993) J Exp Med , vol.178 , pp. 1309-1320
    • Xu-Amano, J.1    Kiyono, H.2    Raymond, J.3
  • 64
    • 0033015166 scopus 로고    scopus 로고
    • Nasal immunization induces Haemophilus influenza-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity
    • (1999) J Infect Dis , vol.180 , pp. 122-132
    • Kurono, Y.1    Yamamoto, M.2    Fujihashi, K.3
  • 66
    • 0032219522 scopus 로고    scopus 로고
    • Mucosal immunoadjuvant activity of recombinant Escherichia coli heat-labile enterotoxin and its B subunit: Induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with influenza virus surface antigen
    • (1998) Vaccine , vol.16 , Issue.20 , pp. 2069-2076
    • Verweij, W.R.1    De Haan, L.2    Holtrop, M.3
  • 67
    • 0029959974 scopus 로고    scopus 로고
    • Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat-labile enterotoxin B subunit containing a trace amount of the holotoxin
    • (1996) Vaccine , vol.14 , pp. 113-119
    • Hashigucci, K.1    Ogawa, H.2    Ishidate, T.3
  • 68
    • 0344564184 scopus 로고    scopus 로고
    • Phase 1 evaluation of intranasal virosomal influenza vaccine with and without Escherichia coli heat-labile toxin in adult volunteers
    • (1999) J Virol , vol.73 , Issue.9 , pp. 7780-7786
    • Glück, U.1    Gebbers, J.O.2    Glück, R.3
  • 69
    • 0034072432 scopus 로고    scopus 로고
    • Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant
    • (2000) J Infect Dis , vol.181 , Issue.3 , pp. 1129-1132
    • Glück, R.1    Mischler, R.2    Durrer, P.3
  • 72
    • 0023938398 scopus 로고
    • Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens
    • (1988) Vaccine , vol.6 , pp. 269-277
    • Clements, J.D.1    Hartzog, N.M.2    Lyon, F.L.3
  • 73
    • 0035863580 scopus 로고    scopus 로고
    • Potency of a genetically detoxified mucosal adjuvant derived from the heat-labile enterotoxin of Escherichia coli (LTK63) is not adversely affected by the presence of preexisting immunity to the adjuvant
    • (2001) J Infect Dis , vol.183 , pp. 351-354
    • Ugozzoli, M.1    Santos, G.2    Donnelly, J.3    O'Hagan, D.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.