Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours

Pathology

Volumn 39, Issue 6, 2007, Pages 558-564

  Karamitopoulou, Eva ^a   Cioccari, Luca ^a   Jakob, Sabine ^a   Vallan, Claudio ^a   Schaffner, Thomas ^a   Zimmermann, Arthur ^a   Brunner, Thomas ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Apoptosis; Caspases; Colorectal carcinoma; DNA fragmentation; Hepatocellular carcinoma; Immunohistochemistry

Indexed keywords

CASPASE 3; DNA FRAGMENT; SINGLE STRANDED DNA;

APOPTOSIS; ARTICLE; CELL DEATH; COLORECTAL CARCINOMA; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TUMOR; METASTASIS; PROTEIN ANALYSIS;

EID: 36248952844     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1080/00313020701684375     Document Type: Article

References (26)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
2. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-8.
3. Green DR, Evan GI. A matter of life and death. Cancer Cell 2002; 1: 19-30.
4. Pelengaris S, Kahn M, Evan G. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002; 109: 321-34.
5. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-57.
6. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980; 68: 251-306.
7. Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature 2000; 407: 784-8.
8. Zhao M, Zimmermann A. Apoptosis in human hepatocellular carcinoma and in liver cell dysplasia is correlated with p53 protein immunoreactivity. J Clin Pathol 1997; 50: 394-400.
9. Lin T, Brunner T, Tietz B, et al. Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest 1998; 101: 570-7.
10. Sloop GD, Roa JC, Delgado AG, et al. Histologic sectioning produces TUNEL reactivity. A potential cause of false-positive staining. Arch Pathol Lab Med 1999; 123: 529-32.
11. Korkolopoulou PA, Konstantinidou AE, Patsouris ES, et al. Detection of apoptotic cells in archival tissue from diffuse astrocytomas using a monoclonal antibody to single-stranded DNA. J Pathol 2001; 193: 377-82.
12. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6.
13. Martin SJ, Green DR. Protease activation during apoptosis: death by a thousand cuts? Cell 1995; 82: 349-52.
14. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 2003; 10: 76-100.
15. Muris JJ, Cillessen SA, Vos W, et al. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005; 105: 2916-23.
16. Singh RP, Agarwal R. Tumor angiogenesis: a potential target in cancer control by phytochemicals. Curr Cancer Drug Targets 2003; 3: 205-17.
17. Seeff LB. Introduction: The burden of hepatocellular carcinoma. Gastroenterology 2004; 127: S1-4.
18. Weiss L, Grundmann E, Torhorst J, et al. Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 1986; 150: 195-203.
19. Martin SJ, Green DR. Apoptosis as a goal of cancer therapy. Curr Opin Oncol 1994; 6: 616-21.
20. Martin SJ, Green DR. Apoptosis and cancer: the failure of controls on cell death and cell survival. Crit Rev Oncol Hematol 1995; 18: 137-53.
21. Caulin C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997; 138: 1379-94.
22. Enari M, Sakahira H, Yokoyama H, et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391: 43-50.
23. Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391: 96-9.
24. Petrache I, Birukov K, Zaiman AL, et al. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Faseb J 2003; 17: 407-16.
25. Stegh AH, Herrmann H, Lampel S, et al. Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis. Mol Cell Biol 2000; 20: 5665-79.
26. Bartl MM, Luckenbach T, Bergner O, Ullrich O, Koch-Brandt C. Multiple receptors mediate apoJ-dependent clearance of cellular debris into nonprofessional phagocytes. Exp Cell Res 2001; 271: 130-41.