Detection of apoptotic cells in archival tissue from diffuse astrocytomas using a monoclonal antibody to single-stranded DNA

Journal of Pathology

Volumn 193, Issue 3, 2001, Pages 377-382

  Korkolopoulou, Penelope A ^a,b   Konstantinidou, Anastasia E ^a   Patsouris, Efstratios S ^a   Christodoulou, Panayota N ^b   Thomas Tsagli, Euphemia A ^b   Davaris, Panayotis S ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b Asklepeion Voula Hospital   (Greece)

Author keywords

Apoptosis; Astrocytoma; Immunohistochemistry; SsDNA; Survival

Indexed keywords

DNA ANTIBODY; FORMALDEHYDE; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; PARAFFIN; PROTEIN P53; SINGLE STRANDED DNA;

ADULT; AGED; APOPTOSIS; ARTICLE; ASTROCYTOMA; CANCER GRADING; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA; HEATING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PATHOLOGY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; TISSUE SECTION; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIBODIES, MONOCLONAL; APOPTOSIS; ASTROCYTOMA; BRAIN NEOPLASMS; CELL DIVISION; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; DNA, SINGLE-STRANDED; FEMALE; HUMANS; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035090922     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH812>3.0.CO;2-W     Document Type: Article

References (28)

1. Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: Relationships and prognostic value
2. Prognostic implications of the proliferative potential of low-grade astrocytomas
3. Prognostic significance of bromodeoxyuridine labeling in primary and recurrent glioblastoma multiforme
4. Apoptosis
5. Apoptosis in cancer therapy: Crossing the threshold
6. Apoptotic cell death induced by local brain hyperthermia in a rat glioma model
7. A study of apoptosis in normal and pathologic nervous tissue after in situ end-labeling of DNA strand breaks
8. Cell death during development of the nervous system
9. A study of apoptosis in brain tumors by in situ end-labeling method
10. Apoptosis in astrocytomas with different grades of malignancy
11. Apoptosis in cerebral astrocytic tumours and its relationship to expression of the bcl-2 and p53 proteins
12. The new WHO classification of brain tumours
13. Brief, high-temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues
14. Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA. Relation to bcl-2 expression, hormone receptors and lymph node metastases
15. Expression of retinoblastoma gene product and p21 (WAF1/Cip1) protein in gliomas: Correlations with proliferation markers, p53 expression and survival
16. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo
17. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis and autolytic cell death: A cautionary note
18. Monoclonal antibody to single-stranded DNA is a specific and cellular marker of apoptosis
19. Nuclear changes in apoptosis
20. Apoptosis. Its significance in cancer and cancer therapy
21. An immunohistochemical study of tissue transglutaminase in gliomas with reference to their cell-dying processes
22. Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma
23. The frequency of apoptosis correlates with the prognosis of Gleason grade 3 adenocarcinoma of the prostate
24. Apoptosis in bladder cancer as related to standard prognostic factors and prognosis
25. Incidence of apoptosis, cell proliferation and bcl-2 expression in transitional cell carcinoma of the bladder. Association with tumor progression
26. The spontaneous apoptotic cell death of normal human lymphocytes in vitro. The release of, and immunoproliferative response to, nucleosomes in vitro
27. The p53 gene and protein in human brain tumors
28. Pleiotropic drug resistance and survival advantage in leukemic cells with diminished apoptotic response