Protein kinase C-zeta (PKC-ζ) regulates Kupffer cell apoptosis during experimental sepsis

Journal of Gastrointestinal Surgery

Volumn 11, Issue 12, 2007, Pages 1712-1721

  Peng, Yanhua ^a   Sigua, Celia A ^a   Karsonovich, Cynthia ^a   Murr, Michel M ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Apoptosis; Kupffer cells; Liver injury; PKC ; Sepsis

Indexed keywords

CHAPERONE; I KAPPA B KINASE; PRKCZ PROTEIN, RAT; UNCLASSIFIED DRUG;

ANIMAL; APOPTOSIS; ARTICLE; DNA FRAGMENTATION; GENE TRANSLOCATION; KUPFFER CELL; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SEPSIS; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; APOPTOSIS; DNA FRAGMENTATION; I-KAPPA B KINASE; KUPFFER CELLS; MALE; MOLECULAR CHAPERONES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TRANSLOCATION, GENETIC; UP-REGULATION;

EID: 36148993630     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-007-0314-9     Document Type: Article

References (21)

1. Keller SA, Paxian M, Ashburn JH, Clemens MG, Huynh T. Kupffer cell ablation improves hepatic microcirculation after trauma and sepsis. J Trauma 2005;58(4):740-749; discussion 749-751.
2. Murr MM, Yang J, Fier A, Kaylor P, Mastorides S, Norman JG. Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-Kappa B. J Gastrointest Surg 2002;6(3):474-480.
3. Diehl AM. Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines. Am J Physiol Gastrointest Liver Physiol 2002;282(1):G1-5.
4. Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, Lotze MT, Geller DA, Billiar TR. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005;175(11):7661-7668.
5. Murr MM, Yang J, Fier A, Gallagher SF, Carter G, Gower WR, Jr, Norman JG. Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB. J Gastrointest Surg 2003;7(1):20-25.
6. Gallagher SF, Peng Y, Haines K, Baksh K, Epling-Burnette PK, Yang J, Murr MM. Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. J Gastrointest Surg 2005;9(4):467-474; discussion 474-475.
7. Peng Y, Gallagher SF, Haines K, Baksh K, Murr MM. Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. J Surg Res 2006;130(1):58-65.
8. Duran A, Rodriguez A, Martin P, Serrano M, Flores JM, Leitges M, Diaz-Meco MT, Moscat J. Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J 2004;23(23):4595-4605.
9. Leroy I, de Thonel A, Laurent G, Quillet-Mary A. Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis. Cell Signal 2005;17(9):1149-1157.
10. Xiong S, She H, Sung CK, Tsukamoto H. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 2003;30(2):107-113.
11. Standaert ML, Galloway L, Karnam P, Bandyopadhyay G, Moscat J, Farese RV. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J Biol Chem 1997;272(48):30075-30082.
12. Yang J, Gallagher SF, Haines K, Epling-Burnette PK, Bai F, Gower WR, Jr, Mastorides S, Norman JG, Murr MM. Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death. J Gastrointest Surg 2004;8(2):166-174.
13. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 2003;38(5):1188-1198.
14. Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A. Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol 2003;74(3):344-351.
15. Moscat J, Diaz-Meco MT, Rennert P. NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep 2003;4(1):31-36.
16. Duran A, Diaz-Meco MT, Moscat J. Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J 2003;22(15):3910-3918.
17. Peng Y, Sigua CA, Gallagher SF, Murr MM. Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis. Surgery 2007 (under revision).
18. Peng Y, Sigua CA, Gallagher SF, Murr MM. Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. J Gastrointest Surg 2007;11:1253-1261.
19. Moscat J, Diaz-Meco MT. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep 2000;1(5):399-403.
20. Ruocco MG, Karin M. IKK beta as a target for treatment of inflammation induced bone loss. Ann Rheum Dis 2005;64 Suppl 4:iv81-85.
21. Dallot E, Mehats C, Oger S, Leroy MJ, Breuiller-Fouche M. A role for PKCzeta in the LPS-induced translocation NF-kappaB p65 subunit in cultured myometrial cells. Biochimie 2005;87(6):513-521.