Microarray analysis of aberrant gene expression in actinic keratosis: Effect of the Toll-like receptor-7 agonist imiquimod

British Journal of Dermatology

Volumn 157, Issue 6, 2007, Pages 1132-1147

  Torres, A ^a   Storey, L ^a   Anders, M ^a   Miller, R L ^b   Bulbulian, B J ^b   Jin, J ^b   Raghavan, S ^b   Lee, J ^b   Slade, H B ^b   Birmachu, W ^b  

^a LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

^b 3M COMPANY   (United States)

Author keywords

Actinic keratosis; Confocal microscopy; Gene expression; Imiquimod; Microarray

Indexed keywords

IMIQUIMOD; TOLL LIKE RECEPTOR 7;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFOCAL MICROSCOPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DEVICE; DIAGNOSTIC PROCEDURE; DNA MICROARRAY; DOUBLE BLIND PROCEDURE; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; ONCOGENE; PHARMACOGENETICS; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUN EXPOSURE; SUNBURN; TUMOR SUPPRESSOR GENE; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; AGED; AGED, 80 AND OVER; AMINOQUINOLINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; GENE EXPRESSION; HUMANS; KERATOSIS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOTOSENSITIVITY DISORDERS; SCALP DERMATOSES; TOLL-LIKE RECEPTOR 7; TREATMENT OUTCOME;

EID: 36148982714     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2007.08218.x     Document Type: Article

References (71)

1. Callen JP, Bickers DR, Moy RL. Actinic keratosis. J Am Acad Dermatol 1997 36 : 650 3.
2. Marks R, Rennie G, Selwood T. The relationship of basal cell carcinomas and squamous cell carcinomas to solar keratoses. Arch Dermatol 1988 124 : 1039 42.
3. Edwards L, Levine N, Weidner M, Piepkorn M. Effect of intralesional alpha2 interferon on actinic keratosis. Arch Dermatol 1986 122 : 779 82.
4. Yantsos VA, Conrad N, Zabawski E, Cockerell CJ. Incipient intraepidermal cutaneous squamous cell carcinoma: a proposal for reclassifying and grading solar (actinic) keratoses. Semin Cutan Med Surg 1999 18 : 3 14.
5. Murakami T, Fujimoto M, Ohtsuki M, Nakagawa H. Expression profiling of cancer-related genes in human keratinocytes following non-lethal ultraviolet B irradiation. J Dermatol Sci 2001 27 : 121 9.
6. Wertz K, Hunziker PB, Seifert N et al. β-carotene interferes with ultraviolet light A-induced gene expression by multiple pathways. J Invest Dermatol 2005 124 : 428 34.
7. Rundhaug JE, Hawkins KA, Pavone A et al. SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects. Mol Carcinog 2005 42 : 40 52.
8. Cockerell CJ. Histopathology of incipient intraepidermal squamous cell carcinoma ('actinic keratosis'). J Am Acad Dermatol 2000 42 : 11 17.
9. Park HR, Min SK, Cho HD et al. Expression profiles of p63, p53, survivin, and hTERT in skin tumors. J Cutan Pathol 2004 31 : 544 9.
10. Fu W, Cockerell CJ. The actinic (solar) keratosis: a 21st-century perspective. Arch Dermatol 2003 139 : 66 70.
11. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol 2000 42 : 23 4.
12. Mittelbronn MA, Mullins DL, Ramos-Caro FA, Flowers FP. Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma. Int J Dermatol 1998 37 : 677 81.
13. Silapunt S, Goldberg LH, Alam M. Topical and light-based treatments for actinic keratoses. Semin Cutan Med Surg 2003 22 : 162 70.
14. Szeimies RM, Gerritsen MJ, Gupta G et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol 2004 51 : 547 55.
15. Urosevic M, Maier T, Benninghoff B et al. Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo. Arch Dermatol 2003 139 : 1325 32.
16. Barnetson RS, Stachell A, Zhuang L et al. Imiquimod-induced regression of clinically diagnosed superficial basal cell carcinoma is associated with early infiltration by CD4 T cells and dendritic cells. Clin Exp Dermatol 2004 29 : 639 43.
17. Beutner KR, Tyring SK, Trofatter KF Jr. et al. Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts. Antimicrob Agents Chemother 1998 42 : 789 94.
18. Hemmi H, Kaisho T, Takeuchi O et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002 3 : 196 200.
19. Miller RL, Gerster JF, Owens ML et al. Imiquimod applied topically: a novel immune response modifier and a new class of drug. Int J Immunopharmacol 1999 21 : 1 14.
20. Gibson SJ, Lindh JM, Riter TR et al. Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol 2002 218 : 74 86.
21. Torres A, Storey L, Anders M et al. Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream. J Transl Med 2007 5 : 7.
22. Ooi T, Barnetson RS, Zhuang L et al. Imiquimod-induced regression of actinic keratosis is associated with infiltration by T lymphocytes and dendritic cells: a randomized controlled trial. Br J Dermatol 2006 154 : 72 8.
23. Gonzalez S, Swindells K, Rajadhyaksha M, Torres A. Changing paradigms in dermatology: confocal microscopy in clinical and surgical dermatology. Clin Dermatol 2003 21 : 359 69.
24. Aghassi D, Anderson RR, Gonzalez S. Confocal laser microscopic imaging of actinic keratoses in vivo: a preliminary report. J Am Acad Dermatol 2000 43 : 42 8.
25. Torres A, Niemeyer A, Berkes B et al. 5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs' micrographic surgery for treatment of basal cell carcinoma. Dermatol Surg 2004 30 : 1462 9.
26. Curiel-Lewandrowski C, Williams CM, Swindells KJ et al. Use of in vivo confocal microscopy in malignant melanoma: an aid in diagnosis and assessment of surgical and nonsurgical therapeutic approaches. Arch Dermatol 2004 140 : 1127 32.
27. Langley RG, Burton E, Walsh N et al. In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna. J Am Acad Dermatol 2006 55 : 88 97.
28. Winer J, Kwang C, Jung S et al. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 1999 270 : 41 9.
29. Affymetrix Inc. GeneChip Expression Analysis Technical Manual. 2003. http://gg.bu.edu/microarray/expression_manual.pdf (accessed 7 August 2007).
30. Schindler H, Wiese A, Auer J, Burtscher H. cRNA target preparation for microarrays: comparison of gene expression profiles generated with different amplification procedures. Anal Biochem 2005 344 : 92 101.
31. Klur S, Toy K, Williams MP, Certa U. Evaluation of procedures for amplification of small-size samples for hybridization on microarrays. Genomics 2004 83 : 508 17.
32. Zeeberg BR, Feng W, Wang G et al. GoMiner: a resource for biological interpretation of genomic and proteomic data. Genome Biol 2003 4 : R28.
33. Mischke D, Korge BP, Marenholz I et al. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ('epidermal differentiation complex') on human chromosome 1q21. J Invest Dermatol 1996 106 : 989 93.
34. Marshall D, Hardman MJ, Nield KM, Byrne C. Differentially expressed late constituents of the epidermal cornified envelope. Proc Natl Acad Sci 2001 98 : 13031 6.
35. Amano S, Akutsu N, Matsunaga Y et al. Importance of balance between extracellular matrix synthesis and degradation in basement membrane formation. Exp Cell Res 2001 271 : 249 62.
36. Copland JA, Luxon BA, Ajani L et al. Genomic profiling identifies alterations in TGFβ signaling through loss of TGFβ receptor expression in human renal cell carcinogenesis and progression. Oncogene 2003 22 : 8053 62.
37. Bandyopadhyay A, Zhu Y, Malik SN et al. Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene 2002 21 : 3541 51.
38. Jang JH. Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis. Oncogene 2005 24 : 945 8.
39. Homey B, Alenius H, Muller A et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 2002 8 : 157 65.
40. Gao W, Kumar S, Lotze MT, Hanning C. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol 2003 170 : 107 13.
41. Reifenberger J, Knobbe CB, Wolter M et al. Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. Int J Cancer 2002 100 : 549 56.
42. Andress DL. Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor. Am J Physiol Endocrinol Metab 1988 274 : E744 50.
43. Butt AJ, Dickson KA, McDougall F, Baxter RC. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J Biol Chem 2003 278 : 29676 85.
44. Oh JS, Kucab JE, Bushel PR et al. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. Neoplasia 2002 4 : 204 17.
45. Ongusaha PP, Kwak JC, Zwible AJ et al. HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res 2004 64 : 5283 90.
46. Mori S, Tanaka M, Nanba D et al. PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. J Biol Chem 2003 278 : 46029 34.
47. Del Bino S, Vioux C, Rossio-Pasquier P et al. Ultraviolet B induces hyperproliferation and modification of epidermal differentiation in normal human skin grafted on to nude mice. Br J Dermatol 2004 150 : 658 67.
48. Haider AS, Peters SB, Kaporis H et al. Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 2006 126 : 869 81.
49. Bowcock AM, Shannon W, Du F et al. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genetics 2001 10 : 1793 805.
50. van de Rijn M, Perou CM, Tibshirani R et al. Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome. Am J Pathol 2002 161 : 1991 6.
51. Carrilho C, Alberto M, Buane L, David L. Keratins 8, 10, 13 and 17 are useful markers in the diagnosis of human cervix carcinomas. Hum Pathol 2004 35 : 546 51.
52. Choi P, Chen C. Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma. Cancer 2005 104 : 1113 28.
53. Sugiura H, Ebise H, Tazawa T et al. Large-scale DNA microarray analysis of atopic skin lesions shows expression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope. Br J Dermatol 2005 152 : 146 9.
54. Komatsu N, Saijoh K, Toyama T et al. Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 2005 153 : 274 81.
55. Borgono CA, Michael IP, Diamandis EP. Human tissue kallikreins: physiologic roles and applications in cancer. Mol Cancer Res 2004 2 : 257 80.
56. Ruokolainen H, Paakko P, Turpeenniemi-Hujanen T. Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma: a potential marker for prognosis. Clin Cancer Res 2004 10 : 3110 16.
57. Tanimura S, Asato K, Fujishiro SH, Kohno M. Specific blockade of the ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44. Biochem Biophys Res Commun 2003 304 : 801 6.
58. Ramos MC, Steinbrenner H, Stuhlmann D et al. Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet irradiation. Biol Chem 2004 385 : 75 86.
59. Takeda A, Kajiya A, Iwasawa A et al. Aberrant expression of serpin squamous cell carcinoma antigen 2 in human tumor tissues and cell lines: evidence of protection from tumor necrosis factor-mediated apoptosis. Biol Chem 2002 383 : 1231 6.
60. Gao JQ, Tsuda Y, Katayama K et al. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Cancer Res 2003 63 : 4420 5.
61. Strieter RM, Belperio JA, Phillips RJ, Keane MP. CXC chemokines in angiogenesis of cancer. Semin Cancer Biol 2004 14 : 195 200.
62. Vicari AP, Caux C. Chemokines in cancer. Cytokine Growth Factor Rev 2002 13 : 143 54.
63. Nghiem DX, Kazimi N, Mitchell DL et al. Mechanisms underlying the suppression of established immune responses by ultraviolet radiation. J Invest Dermatol 2002 119 : 600 8.
64. McMahon AP. The WNT family of developmental regulators. Trends Genet 1992 8 : 236 42.
65. Weeraratna AT, Jiang Y, Hostetter G et al. WNT5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002 1 : 279 88.
66. Taki M, Kamata N, Yokoyama K et al. Down-regulation of WNT-4 and up-regulation of WNT-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 2003 94 : 593 7.
67. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001 20 : 2390 400.
68. Jochum W, Passegue E, Wagner EF. AP-1 in mouse development and tumorigenesis. Oncogene 2001 20 : 2401 12.
69. Mehic D, Bakiri L, Ghannadan M et al. Fos and jun proteins are specifically expressed during differentiation of human keratinocytes. J Invest Dermatol 2005 124 : 212 20.
70. Mangone FR, Brentani MM, Nonogaki S et al. Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinoma. Int J Exp Pathol 2005 86 : 205 12.
71. Bieche I, Lerebours F, Tozlu S et al. Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature. Clin Cancer Res 2004 10 : 6789 95.