Fos and Jun proteins are specifically expressed during differentiation of human keratinocytes

Journal of Investigative Dermatology

Volumn 124, Issue 1, 2005, Pages 212-220

  Mehic, Denis ^a   Bakiri, Latifa ^b   Ghannadan, Minoo ^a   Wagner, Erwin F ^b   Tschachler, Erwin ^a,c  

^a Universitatsklinik fur Dermatologie   (Austria)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c Centre de Recherches et d'Investigations   (France)

Author keywords

AP 1; Hyperproliferation; Keratinocytes; Skin equivalents

Indexed keywords

PROTEIN C JUN; PROTEIN FOS; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BASAL CELL; CELL DIFFERENTIATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; EPIDERMIS; GRANULAR CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MONOLAYER CULTURE; NORMAL HUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; STRATUM CORNEUM;

EID: 11944256457     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23558.x     Document Type: Article

References (38)

1. Aggarwal BB: Signaling pathways of the TNF superfamily: A double-edged sword. Nat Rev Immunol 3:745-756, 2003
2. Angel P, Szabowski A, Schorpp-Kistner M: Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 20:2413-2423, 2001
3. Basset-Seguin N, Demoly P, Moles JR et al: Comparative analysis of cellular and tissular expression of c-fos in human keratinocytes: Evidence of its role in cell differentiation. Oncogene 9:765-771, 1994
4. Basset-Seguin N, Escot C, Blanchard JM, Kerai C, Verrier B, Mion H, Guilhou JJ: High levels of c-fos proto-oncogene expression in normal human adult skin. J Invest Dermatol 94:418-422, 1990
5. Basset-Seguin N, Escot C, Moles JP, Blanchard JM, Kerai C, Guilhou JJ: C-fos and c-jun proto-oncogene expression is decreased in psoriasis: An in situ quantitative analysis. J Invest Dermatol 97:672-678, 1991
6. Bernerd F, Magnaldo T, Darmon M: Delayed onset of epidermal differentiation in psoriasis. J Invest Dermatol 98:902-910, 1992
7. Briata P, D'Anna F, Franzi AT, Gherzi R: AP-1 activity during normal human keratinocyte differentiation: Evidence for a cytosolic modulator of AP-1/DNA binding. Exp Cell Res 204:136-146, 1993
8. Casatorres J, Navarro JM, Blessing M, Jorcano JL: Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element. J Biol Chem 269:20489-20496, 1994
9. Chaturvedi V, Qin JZ, Denning MF, Choubey D, Diaz MO, Nickoloff BJ: Apoptosis in proliferating, senescent, and immortalized keratinocytes. J Biol Chem 274:23358-23367, 1999
10. DiSepio D, Jones A, Longley MA, Bundman D, Rothnagel JA, Roop DR: The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression. J Biol Chem 270:10792-10799, 1995
11. Dover R, Watt FM: Measurement of the rate of epidermal terminal differentiation: Expression of involucrin by S-phase kerationocytes in culture and in psoriatic plaques. J Invest Dermatol 89:349-352, 1987
12. Eckert RL, Crish JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77:397-424, 1997
13. Eickhart L, Declercq W, Ban J, et al: Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation. J Invest Dermatol 115:1148-1151, 2000
14. Eferl R, Wagner EF: AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer 3:859-868, 2003
15. Ettehadi P, Greaves MW, Wallach D, Aderka D, Camp RD: Elevated tumour necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions. Clin Exp Immunol 96:146-151, 1994
16. Fuchs E, Byrne C: The epidermis: Rising to the surface. Curr Opin Genet Dev 4:725-736, 1994
17. Fusenig NE: Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro. In: Leigh I, Watt B, Lane F, (eds). The Keratinocyte Handbook. Cambridge University Press, 1994, p 71-94.
18. Gandarillas A, Watt FM: Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes. Oncogene 11:1403-1407, 1995
19. Greenhalgh DA, Rothnagel JA, Wang XJ, et al: Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia. Oncogene 8:2145-2157, 1993
20. Hanley K, Wood L, Ng DC, et al: Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. J Lipid Res 42:390-398, 2001
21. Jang SI, Steinert PM, Markova NG: Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. J Biol Chem 271:24105-24114, 1996
22. Jochum W, Passegue E, Wagner EF: AP-1 in mouse development and tumorigenesis. Oncogene 20:2401-2412, 2001
23. Kirby B, Griffiths CE: Novel immune-based therapies for psoriasis. Br J Dermatol 146:546-551, 2002
24. Li G, Gustafson-Brown C, Hanks SK, et al: c-Jun is essential for organization of the epidermal leading edge. Dev Cell 4:865-877, 2003
25. Liew FM, Yamanishi K: Regulation of transglutaminase 1 gene expression by 12-O-tetradecanoylphorbol-13-acetate, dexamethasone, and retinoic acid in cultured human keratinocytes. Exp Cell Res 202:310-315, 1992
26. Lu B, Rothnagel JA, Longley MA, Tsai SY, Roop DR: Differentiation- specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J Biol Chem 269:7443-7449, 1994
27. Ma S, Rao L, Freedberg IM, Blumenberg M: Transcriptional control of K5, K6, K14, and K17 keratin genes by AP-1 and NF-kappaB family members. Gene Exp 6:361-370, 1997
28. Medvedev A, Saunders NA, Matsuura H, Chistokhina A, Jetten AM: Regulation of the transglutaminase I gene. Identification of DNA elements involved in its transcriptional control in tracheobronchial epithelial cells. J Biol Chem 274:3887-3896, 1999
29. Rendl M, Ban J, Mrass P, et al: Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. J Invest Dermatol 119:1150-1155, 2002
30. Rossi A, Jang SI, Ceci R, Steinert PM, Markova NG: Effect of AP1 transcription factors on the regulation of transcription in normal human epidermal keratinocytes. J Invest Dermatol 110:34-40, 1998
31. Shaulian E, Karin M: AP-1 in cell proliferation and survival. Oncogene 20:2390-2400, 2001
32. Stark HJ, Baur M, Breitkreutz D, Mirancea N, Fusenig NE: Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation. J Invest Dermatol 112:681-691, 1999
33. Stern RS: Psoriasis. Lancet 350:349-353, 1997
34. Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schorpp-Kistner M, Fusenig NE, Angel P: c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103:745-755, 2000
35. van Dam H, Castellazzi M: Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis. Oncogene 20:2453-2464, 2001
36. Welter JF, Crish JF, Agarwal C, Eckert RL: Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem 270:12614-12622, 1995
37. Welter JF, Eckert RL: Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, JunB and junD during human epidermal keratinocyte differentiation. Oncogene 11:2681-2687, 1995
38. Zenz R, Scheuch H, Martin P, et al: c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell 4:879-889, 2003