Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5824-5832

  Petersen, Kimberly S ^a   Dolan, Patrick M ^b   Kensler, Thomas W ^b   Peleg, Sara ^c   Posner, Gary H ^a,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 5 TRIMETHYLAMMONIOMETHYL 1,3 OXATHIOLANE; CALCITRIOL; CALCITRIOL DERIVATIVE; CALCIUM; ETHER DERIVATIVE; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CALCIUM URINE LEVEL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GENE CONTROL; KERATINOCYTE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKYNES; ALLYL COMPOUNDS; ANIMALS; BENZYL COMPOUNDS; BINDING, COMPETITIVE; CALCITRIOL; CALCIUM; CALCIUM CHANNELS; CELL LINE; CELL PROLIFERATION; DUODENUM; FEMALE; HUMANS; KERATINOCYTES; MICE; MICE, INBRED C57BL; RATS; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRPV CATION CHANNELS;

EID: 36148962385     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070882d     Document Type: Article

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