LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells

International Journal of Oncology

Volumn 29, Issue 1, 2006, Pages 249-253

  Ohnishi, Ken ^a   Yasumoto, Jun Ichi ^a   Takahashi, Akihisa ^a   Ohnishi, Takeo ^a  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Heat; Inhibitor; LY294002; p53

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; BIRC5 PROTEIN, HUMAN; CHROMONE DERIVATIVE; DNA; DNA BINDING PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 72; HEAT SHOCK TRANSCRIPTION FACTOR; HSPB1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN P53; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; COMPARATIVE STUDY; DNA RESPONSIVE ELEMENT; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEAT; HUMAN; HYPERTHERMIC THERAPY; LUNG TUMOR; METABOLISM; MUTATION; PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; DNA; DNA-BINDING PROTEINS; HEAT; HEAT-SHOCK PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; HYPERTHERMIA, INDUCED; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; MORPHOLINES; MUTATION; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR STEM CELL ASSAY; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 36049015403     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.29.1.249     Document Type: Article

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