-
2
-
-
3242686833
-
Tha price tag on progress - chemotherapy for colorectal cancer
-
Schrag D. Tha price tag on progress - chemotherapy for colorectal cancer. N Engl J Med 2004; 351: 317-319.
-
(2004)
N Engl J Med
, vol.351
, pp. 317-319
-
-
Schrag, D.1
-
3
-
-
0037421590
-
Pharmacogenomics-drug disposition, drug targets, and side effects
-
Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 2003; 348: 538-549.
-
(2003)
N Engl J Med
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
5
-
-
20044369371
-
Toward genome-wide SNP genotyping
-
Syvanen AC. Toward genome-wide SNP genotyping. Nat Genet 2005; 37S: S5-10.
-
(2005)
Nat Genet
, vol.37 S
-
-
Syvanen, A.C.1
-
6
-
-
0035776497
-
Methods for genotyping single nucleotide polymorphisms
-
Kwok PY. Methods for genotyping single nucleotide polymorphisms. Annu Rev Genomics Hum Genet 2001; 2: 235-258.
-
(2001)
Annu Rev Genomics Hum Genet
, vol.2
, pp. 235-258
-
-
Kwok, P.Y.1
-
8
-
-
23044433245
-
Pharmacogenetics goes 3D
-
McLeod HL, Marsh S. Pharmacogenetics goes 3D. Nat Genet 2005; 37: 794-795.
-
(2005)
Nat Genet
, vol.37
, pp. 794-795
-
-
McLeod, H.L.1
Marsh, S.2
-
9
-
-
4344619012
-
The use and development of germline polymorphisms in clinical oncology
-
Lenz HJ. The use and development of germline polymorphisms in clinical oncology. J Clin Oncol 2004; 22: 2519-2521.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2519-2521
-
-
Lenz, H.J.1
-
10
-
-
16344366323
-
Gene expression profiling of the irinotecan pathway in Golorectal cancer
-
Yu J, Shannon WD, Watson MA, McLeod HL. Gene expression profiling of the irinotecan pathway in Golorectal cancer. Clin Cancer Res 2005; 11: 2053-2062.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2053-2062
-
-
Yu, J.1
Shannon, W.D.2
Watson, M.A.3
McLeod, H.L.4
-
11
-
-
23044474063
-
Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes
-
Cheng Q, Yang W, Raimondi SC et al. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nat Genet 2005; 37: 878-882.
-
(2005)
Nat Genet
, vol.37
, pp. 878-882
-
-
Cheng, Q.1
Yang, W.2
Raimondi, S.C.3
-
12
-
-
33747133256
-
Epigenetics: An emerging technology in the diagnosis and treatment of cancer
-
Stebbing J, Bower M, Syed N et al. Epigenetics: An emerging technology in the diagnosis and treatment of cancer. Pharmacogenomics 2006; 7: 747-757,
-
(2006)
Pharmacogenomics
, vol.7
, pp. 747-757
-
-
Stebbing, J.1
Bower, M.2
Syed, N.3
-
13
-
-
28444480186
-
Concordance of pharmacogenetic markers in germline and colorectal tumor DNA
-
Marsh S, Mallon MA, Goodfellow P, McLeod HL. Concordance of pharmacogenetic markers in germline and colorectal tumor DNA. Pharmacogenomics 2005; 6: 873-877.
-
(2005)
Pharmacogenomics
, vol.6
, pp. 873-877
-
-
Marsh, S.1
Mallon, M.A.2
Goodfellow, P.3
McLeod, H.L.4
-
14
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans WE, Relling MV. Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 1999; 286: 487-491.
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
15
-
-
29244461993
-
Pharmacogenetics of colorectal cancer
-
Marsh S, Pharmacogenetics of colorectal cancer, Expert Opin Pharmacother 2005; 6: 2607-2616.
-
(2005)
Expert Opin Pharmacother
, vol.6
, pp. 2607-2616
-
-
Marsh, S.1
-
16
-
-
33646152560
-
Cancer Pharmacogenetics: The Move from Pharmacokinetics to Pharmacodynamics
-
Hoskins JM, Mcleod HL. Cancer Pharmacogenetics: The Move from Pharmacokinetics to Pharmacodynamics. Current Pharmacogenomics 2006; 4: 39-46.
-
(2006)
Current Pharmacogenomics
, vol.4
, pp. 39-46
-
-
Hoskins, J.M.1
Mcleod, H.L.2
-
17
-
-
33745165575
-
Global pharmacogenetics: Giving the genome to the masses
-
Marsh S, Van Booven DJ, McLeod HL. Global pharmacogenetics: Giving the genome to the masses. Pharmacogenomics 2006; 7: 625-631.
-
(2006)
Pharmacogenomics
, vol.7
, pp. 625-631
-
-
Marsh, S.1
Van Booven, D.J.2
McLeod, H.L.3
-
19
-
-
0036024997
-
SNP databases and pharmacogenetics: Great start, but a long way to go
-
Marsh S, Kwok P, McLeod HL. SNP databases and pharmacogenetics: Great start, but a long way to go. Hum Mutat 2002; 20: 174-179.
-
(2002)
Hum Mutat
, vol.20
, pp. 174-179
-
-
Marsh, S.1
Kwok, P.2
McLeod, H.L.3
-
20
-
-
33749484971
-
Candidate single nucleotide polymorphism selection using publicly available tools: A guide for epidemiologists
-
Bhatti P, Church DM, Rutter JL et al. Candidate single nucleotide polymorphism selection using publicly available tools: A guide for epidemiologists. Am J Epidemiol 2006; 164: 794-804.
-
(2006)
Am J Epidemiol
, vol.164
, pp. 794-804
-
-
Bhatti, P.1
Church, D.M.2
Rutter, J.L.3
-
22
-
-
28744434487
-
Polymorphism discovery in 51 chemotherapy pathway genes
-
Freimuth RR, Xiao M, Marsh S et al. Polymorphism discovery in 51 chemotherapy pathway genes. Hum Mol Genet 2005; 14: 3595-3603.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 3595-3603
-
-
Freimuth, R.R.1
Xiao, M.2
Marsh, S.3
-
23
-
-
2342624080
-
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
-
Paez JG, Janne PA, Lee JC et al. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy. Science 2004; 304: 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
24
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
25
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004; 101: 13306-13311.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
26
-
-
0033486029
-
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
-
Relling MV, Hancock ML, Rivera GK et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst 1999; 91: 2001-2008.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 2001-2008
-
-
Relling, M.V.1
Hancock, M.L.2
Rivera, G.K.3
-
27
-
-
0036009619
-
The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics
-
McLeod HL, Siva C. The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics 2002; 3: 89-98.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 89-98
-
-
McLeod, H.L.1
Siva, C.2
-
28
-
-
33845899137
-
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure
-
Nackley AG, Shabalina SA, Tchivileva IE et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 2006; 314: 1930-1933.
-
(2006)
Science
, vol.314
, pp. 1930-1933
-
-
Nackley, A.G.1
Shabalina, S.A.2
Tchivileva, I.E.3
-
29
-
-
33748211157
-
Searching for polymorphisms that affect gene expression and mRNA processinig: Example ABCB1 (MDR1)
-
Wang D, Sadee W. Searching for polymorphisms that affect gene expression and mRNA processinig: Example ABCB1 (MDR1). Aaps J 2006; 8: E515-520.
-
Aaps
, vol.J 2006
, Issue.8
-
-
Wang, D.1
Sadee, W.2
-
30
-
-
24344479165
-
ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer
-
Viguier J, Boige V, Miquel C et al. ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer. Clin Cancer Res 2005; 11: 6212-6217.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6212-6217
-
-
Viguier, J.1
Boige, V.2
Miquel, C.3
-
31
-
-
3843130823
-
A multivariate analysis of genomic polymorphisms: Predicton of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
-
Stoehlmacher J, Park DJ, Zhang W et al. A multivariate analysis of genomic polymorphisms: Predicton of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer 2004; 91: 344-354.
-
(2004)
Br J Cancer
, vol.91
, pp. 344-354
-
-
Stoehlmacher, J.1
Park, D.J.2
Zhang, W.3
-
32
-
-
33745830472
-
Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer
-
Kang S, Ju W, Kim JW et al. Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer. Exp Mol Med 2006; 38: 320-324.
-
(2006)
Exp Mol Med
, vol.38
, pp. 320-324
-
-
Kang, S.1
Ju, W.2
Kim, J.W.3
-
33
-
-
33846118697
-
PolymiRTS Database: Linking polymorphisms in microRNA target sites with complex traits
-
Bao L, Zhou M, Wu L et al. PolymiRTS Database: Linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res 2007; 35: D51-54.
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Bao, L.1
Zhou, M.2
Wu, L.3
-
34
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X, McLeod HL, McMurrough J et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 1996; 98: 610-615.
-
(1996)
J Clin Invest
, vol.98
, pp. 610-615
-
-
Wei, X.1
McLeod, H.L.2
McMurrough, J.3
-
35
-
-
0036798968
-
High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
-
Van Kuilenburg AB, Meinsma R, Zoetekouw L, Van Gennip AH. High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity. Pharmacogenetics 2002; 12: 555-558.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 555-558
-
-
Van Kuilenburg, A.B.1
Meinsma, R.2
Zoetekouw, L.3
Van Gennip, A.H.4
-
36
-
-
31544462629
-
Thymidylate synthase pharmacogenetics
-
Marsh S. Thymidylate synthase pharmacogenetics, Invest New Drugs 2005; 23: 533-537.
-
(2005)
Invest New Drugs
, vol.23
, pp. 533-537
-
-
Marsh, S.1
-
37
-
-
0035868667
-
Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
-
Villafranca E, Okruzhnov Y, Dominguez MA et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001; 19: 1779-1786.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1779-1786
-
-
Villafranca, E.1
Okruzhnov, Y.2
Dominguez, M.A.3
-
38
-
-
29244482298
-
Genotype-guided neoadjuvant therapy for rectal cancer
-
McLeod HL, Tan B, Malyapa R et al. Genotype-guided neoadjuvant therapy for rectal cancer. Proc Am Soc Clin Oncol 2005; 23: 197.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
, pp. 197
-
-
McLeod, H.L.1
Tan, B.2
Malyapa, R.3
-
39
-
-
0034518362
-
Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
-
Ulrich CM, Bigler J, Velicer CM et al. Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev 2000; 9: 1381-1385.
-
(2000)
Cancer Epidemiol Biomarkers Prev
, vol.9
, pp. 1381-1385
-
-
Ulrich, C.M.1
Bigler, J.2
Velicer, C.M.3
-
40
-
-
2442480694
-
A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intraturnoral TS mRNA levels
-
Mandola MV, Stoehlmacher J, Zhang W et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intraturnoral TS mRNA levels. Pharmacogenetcs 2004; 14: 319-327.
-
(2004)
Pharmacogenetcs
, vol.14
, pp. 319-327
-
-
Mandola, M.V.1
Stoehlmacher, J.2
Zhang, W.3
-
41
-
-
0028867826
-
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
-
Bosma PJ, Chowdhury JR, Bakker C et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171-1175.
-
(1995)
N Engl J Med
, vol.333
, pp. 1171-1175
-
-
Bosma, P.J.1
Chowdhury, J.R.2
Bakker, C.3
-
42
-
-
0032493441
-
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
-
Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998; 95: 8170-8174.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8170-8174
-
-
Beutler, E.1
Gelbart, T.2
Demina, A.3
-
43
-
-
2342459714
-
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
-
Innocenti F, Undevia SD, Iyer L et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004; 22: 1382-1388.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1382-1388
-
-
Innocenti, F.1
Undevia, S.D.2
Iyer, L.3
-
44
-
-
43149084845
-
-
Invader UGT1A1 molecular assay for irinotecan toxicity. A genetic test for an increased risk of toxicity from the cancer chemotherapy drug irinotecan(Camptosar). Med Lett Drugs Ther 2006; 48: 39-40.
-
Invader UGT1A1 molecular assay for irinotecan toxicity. A genetic test for an increased risk of toxicity from the cancer chemotherapy drug irinotecan(Camptosar). Med Lett Drugs Ther 2006; 48: 39-40.
-
-
-
-
45
-
-
33645686466
-
From bedside to bench to bedside to clinical practice: An odyssey with irinotecan
-
Ratain MJ. From bedside to bench to bedside to clinical practice: An odyssey with irinotecan. Clin Cancer Res 2006; 12: 1658-1660,
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1658-1660
-
-
Ratain, M.J.1
-
46
-
-
1542499495
-
Drug pathways: Moving beyond single gene pharmacogenetics
-
McLeod HL, Drug pathways: Moving beyond single gene pharmacogenetics. Pharmacogenomics 2004; 5: 139-141.
-
(2004)
Pharmacogenomics
, vol.5
, pp. 139-141
-
-
McLeod, H.L.1
-
47
-
-
2942527225
-
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer
-
Sal K, Saeki M, Saito Y et al. UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther 2004; 75: 501-515.
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 501-515
-
-
Sal, K.1
Saeki, M.2
Saito, Y.3
-
49
-
-
6344231838
-
Pharmacogenetics of irinotecan toxicity
-
Marsh S, McLeod HL. Pharmacogenetics of irinotecan toxicity. Pharmacogenomics 2004; 5: 835-843.
-
(2004)
Pharmacogenomics
, vol.5
, pp. 835-843
-
-
Marsh, S.1
McLeod, H.L.2
-
50
-
-
33846012498
-
Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein
-
de Jong FA, Scott-Horton TJ, Kroetz DL et al. Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 2007; 81: 42-49.
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 42-49
-
-
de Jong, F.A.1
Scott-Horton, T.J.2
Kroetz, D.L.3
|