Sex Differences in Renal Nitric Oxide Synthase, NAD(P)H Oxidase, and Blood Pressure in Obese Zucker Rats

Gender Medicine

Volumn 4, Issue 3, 2007, Pages 214-229

  Riazi, Shahla ^a   Madala Halagappa, Veerendra K ^a   Dantas, Ana Paula ^a,b   Hu, Xinqun ^a   Ecelbarger, Carolyn A ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

oxidative stress; radiotelemetry; tandem mass spectroscopy; type 2 diabetes mellitus

Indexed keywords

CALCIFEDIOL; ESTRADIOL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; PROGESTERONE; PROTEIN P47PHOX; PROTEIN P67PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; HIGH SODIUM INTAKE; HORMONE BLOOD LEVEL; HYPERTENSION; IMMUNOBLOTTING; KIDNEY CORTEX; KIDNEY MEDULLA; KIDNEY PARENCHYMA; LEAN BODY WEIGHT; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; TANDEM MASS SPECTROMETRY; TELEMETRY; ZUCKER RAT;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; FEMALE; IMMUNOBLOTTING; MALE; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OBESITY; RATS; RATS, ZUCKER; SEX FACTORS; VASODILATION;

EID: 36048995956     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(07)80042-8     Document Type: Article

References (40)

1. Ford E., and Giles W. Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA 287 (2002) 356-359
2. Wilcox CS. Oxidative stress and nitric oxide deficiency in the kidney: A critical link to hyper- tension?. Am J Physiol Regul lntegr Comp Physiol. 289 (2005) R913-R935
3. Kitiyakara C., Chabrashvili T., Chert Y., et al. Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol. 14 (2003) 2775-2782
4. Dantas A., Franco Mdo C., and Silva-Antonialli M. et al. Gender differences in superoxide generation in microvessels of hypertensive rats: Role of NAD(P)H-oxidase. Cardiovasc Res 61 (2004) 22-29
5. Dantas A., Tostes R., and Fortes Z. et al. In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats. Hypertension 39 (2002) 405-411
6. Kasiske B., O'Donnell M., and Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension. 19 Suppl 1 (1992) II10-II15
7. Erdely A., Greenfeld Z., and Wagner L. Baylis C. Sexual dimorphism in the aging kidney: Effects on injury and nitric oxide system. Kidney Int 63 (2003) 1021-1026
8. Banday A., Marwaha A., and Tallam L. Lokhandwala ME Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 54 (2005) 2219-2226
9. Iida M., Murakami T., and Ishida K. et al. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 222 (1996) 19-26
10. Van Zwieten P., Kam K., and Pijl A. et al. Hypertensive diabetic rats in pharmacological studies. Pharmacol Res 33 (1996) 95-105
11. Ajayi A., and Ogungbade G. Okorodudu AO. Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: Studies in gonadectomized and sham-operated Zucker diabetic rats. Eur J Clin Invest 34 (2004) 349-357
12. Ajayi A., Hercule H., Cory J., et al. Gender difference in vascular and platelet reactivity to throm- boxane A(2)-mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hyper-tensive, hyperinsulinemic) diabetic rats. Diabetes Res Clin Pract 59 (2003) 11-24
13. Song J., Hu X., Shi M., et al. Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure. Am J Physiol Renal Physiol 287 (2004) F1204-F1212
14. Strazzullo P., Barbato A., Vuotto P., and Galletti F. Relationships between salt sensitivity of blood pressure and sympathetic nervous system activity: A short review of evidence. Clin Exp Hypertens 23 (2001) 25-33
15. DiBona G. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens. 11 (2002) 197-200
16. Holst J., Soldin O., and Guo T. Soldin SJ. Steroid hormones: Relevance and measurement in the clinical laboratory. Clin Lab Med 24 (2004) 105-118
17. Ecelbarger C., Kim G., and Terris J. et al. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279 (2000) F46-F53
18. Chen Y., and Gill P. Welch WJ. Oxygen availa bility limits renal NADPH-dependent super-oxide production. Am J Physiol Renal Physiol 289 (2005) F749-F753
19. Riazi S., Madala-Halagappa V., and Hu X. Ecelbarger CA. Sex and body-type interactions in the regula- tion of renal sodium transporter levels, urinary excretion, and activity in lean and obese Zucker rats. Gend Med 3 (2006) 309-327
20. Guyton AC. Role of the kidneys in regulation of arterial pressure and hypertension. In: Wonsiewicz M. (Ed). Textbook of Medical Physiology. (1991), WB Saunders Co;, Philadelphia, Pa 205-219
21. Hall J., Guyton A., and Coleman T. et al. Regulation of arterial pressure: Role of pressure natriuresis and diuresis. Fed Proc 45 (1986) 2897-2903
22. Bianchi G., Fox U., and Di Francesco G. et al. Blood pressure changes produced by kidney cross- transplantation between spontaneously hyper-tensive rats and normotensive rats. Clin Sci Mol Med 47 (1974) 435-448
23. Hall J. The kidney, hypertension, and obesity. Hypertension 41 (2003) 625-633
24. Bosma R., Krikken J., and Homan van der Heide J. et al. Obesity and renal hemodynamics. Contrib Nephrol 151 (2006) 184-202
25. Carlson S., Shelton J., and White C. Wyss JM. Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats. Hypertension 35 (2000) 403-408
26. Reddy S. Kotchen TA. Dietary sodium chloride increases blood pressure in obese Zucker rats. Hypertension 20 (1992) 389-393
27. Kim J., Snider T., Abel M., and Zemel MB. Hypertension in young, healthy Zucker obese rats is not respon- sive to reduced salt intake. J Nutr 124 (1994) 713-716
28. Iliescu R., Yanes L., Bell W., et al. Role of the renal nerves in blood pressure in male and female SHR. Am J Physiol Regul Integr Comp Physiol. 290 (2006) R341-R344
29. Iliescu R., Cucchiarelli V., and Yanes L. et al. Impact of androgen-induced oxidative stress on hyper- tension in male SHR. Am J Physiol Regul Integr Comp Physiol 292 (2007) R731-R735
30. Meischl C. Roos D. The molecular basis of chronic granulomatous disease. Springer Semin Immunopathol 19 (1998) 417-434
31. Welch W., Baumgartl H., and Lubbers D. Wilcox CS. Renal oxygenation defects in the spontaneously hypertensive rat: Role of AT1 receptors. Kidney Int 63 (2003) 202-208
32. Etoh T., Inoguchi T., Kakimoto M., et al. Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insu- lin treatment. Diabetologia 46 (2003) 1428-1437
33. Poirier B., Lannaud-Bournoville M., and Conti M. et al. Oxidative stress occurs in absence of hyper- glycaemia and inflammation in the onset of kidney lesions in normotensive obese rats. Nephrol Dial Transplant 15 (2000) 467-476
34. Reckelhoff J. Gender differences in the regulation of blood pressure. Hypertension. 37 (2001) 1199-1208
35. Masineni S., Chander P., and Singh G. et al. Male gender and not the severity of hypertension is associated with end-organ damage in aged stroke-prone spontaneously hypertensive rats. Am J Hypertens 18 (2005) 878-884
36. Reckelhoff J., Zhang H., and Srivastava K. Gender differences in development of hypertension in spontaneously hypertensive rats: Role of the renin-angiotensin system. Hypertension. 35 (2000) 480-483
37. Reckelhoff J., and Zhang H. Granger JP. Testosterone exacerbates hypertension and reduces pressure- natriuresis in male spontaneously hypertensive rats. Hypertension 31 (1998) 435-439
38. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 92 (2006) 39-48
39. Sakaki T., Kagawa N., and Yamamoto K. Inouye K. Metabolism of vitamin D3 by cytochromes P450. Front Biosci 10 (2005) 119-134
40. Addya S., Zheng Y., and Shayiq R. et al. Characterization of a female-specific hepatic mitochondrial cytochrome P-450 whose steady-state level is modulated by testosterone. Biochemistry 30 (1991) 8323-8330