Sex and body-type interactions in the regulation of renal sodium transporter levels, urinary excretion, and activity in lean and obese zucker rats

Gender Medicine

Volumn 3, Issue 4, 2006, Pages 309-327

  Riazi, Shahla ^a   Madala Halagappa, Veerendra K ^a   Hu, Xinqun ^a   Ecelbarger, Carolyn A ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

diabetes; gender differences; insulin resistance; kidney; renin activity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BENZAMIL; BUMETANIDE; FUROSEMIDE; INSULIN; PROTEIN SUBUNIT; RENIN; SODIUM; SODIUM CHANNEL; SODIUM CHLORIDE; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN 3; THIAZIDE DIURETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY BUILD; CONTROLLED STUDY; FEMALE; IMMUNOBLOTTING; INSULIN BLOOD LEVEL; KIDNEY TUBULE ABSORPTION; LEAN BODY WEIGHT; MALE; NONHUMAN; OBESITY; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; RAT; REGULATORY MECHANISM; RENAL PROTECTION; SALT INTAKE; SEX DIFFERENCE; SODIUM TRANSPORT; URINARY EXCRETION; ZUCKER RAT;

ANIMALS; EPITHELIAL SODIUM CHANNEL; FEMALE; KIDNEY CORTEX; NA(+)-K(+)-EXCHANGING ATPASE; OBESITY; RATS; RATS, ZUCKER; SEX FACTORS; SODIUM CHANNELS; SODIUM CHLORIDE, DIETARY; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; THINNESS;

EID: 34250329823     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(06)80219-6     Document Type: Article

References (61)

1. Brown W.W., and Sandberg K. Introduction: Gender and kidney disease. Adv Ren Replace Ther 10 (2003) 1-2
2. Pechere-Bertschi A., and Burnier M. Female sex hormones, salt, and blood pressure regulation. Am J Hypertens 17 (2004) 994-1001
3. Sandberg K., and Ji H. Sex and the renin angiotensin system: Implications for gender differences in the progression of kidney disease. Adv Ren Replace Ther 10 (2003) 15-23
4. Garza R., Medina R., Basu S., and Pugh J.A. Predictors of the rate of renal function decline in non-insulindependent diabetes mellitus. Am J Nephrol 17 (1997) 59-67
5. Kaseta J.R., Skafar D.F., Ram J.L., et al. Cardiovascular disease in the diabetic woman. J Clin Endocrinol Metab 84 (1999) 1835-1838
6. Lim S.C., Caballero A.E., Arora S., et al. The effect of hormonal replacement therapy on the vascular reactivity and endothelial function of healthy individuals and individuals with type 2 diabetes. J Clin Endocrinol Metab 84 (1999) 4159-4164
7. Seliger S.L., Davis C., and Stehman-Breen C. Gender and the progression of renal disease. Curr Opin Nephrol Hypertens 10 (2001) 219-225
8. Ford E.S., Giles W.H., and Dietz W.H. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA 287 (2002) 356-359
9. Ogden C.L., Carroll M.D., Curtin L.R., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295 (2006) 1549-1555
10. Guyton A.C. Role of the kidneys in regulation of arterial pressure and hypertension. In: Wonsiewicz M.J. (Ed). Textbook of Medical Physiology (1991), WB Saunders Company, Philadelphia, Pa 205-219
11. Knepper M.A. Proteomics and the kidney. J Am Soc Nephrol 13 (2002) 1398-1408
12. Orlowski J., Kandasamy R.A., and Shull G.E. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267 (1992) 9331-9339
13. Magagnin S., Werner A., Markovich D., et al. Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sci USA 90 (1993) 5979-5983
14. Xu J.C., Lytle C., Zhu T.T., et al. Molecular cloning and functional expression of the bumetanidesensitive Na-K-Cl cotransporter. Proc Natl Acad Sci USA 91 (1994) 2201-2205
15. Gamba G., Saltzberg S.N., Lombardi M., et al. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc Natl Acad Sci USA 90 (1993) 2749-2753
16. Canessa C.M., Horisberger J.D., and Rossier B.C. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361 (1993) 467-470
17. Canessa C.M., Schild L., Buell G., et al. Amiloridesensitive epithelial Na+ channel is made of three homologous subunits. Nature 367 (1994) 463-467
18. Duc C., Farman N., Canessa C.M., et al. Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: Localization by in situ hybridization and immunocytochemistry. J Cell Biol 127 (1994) 1907-1921
19. Garty H., and Palmer L.G. Epithelial sodium channels: Function, structure, and regulation. Physiol Rev 77 (1997) 359-396
20. Booth R.E., Tong Q., Medina J., et al. A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating. J Biol Chem 278 (2003) 41367-41379
21. Yang L.M., Rinke R., and Korbmacher C. Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit. J Biol Chem 281 (2006) 9859-9868
22. Kim S.W., Schou U.K., Peters C.D., et al. Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CC14-induced decompensated liver cirrhosis. J Am Soc Nephrol 16 (2005) 3196-3210
23. Snyder P.M. Minireview: Regulation of epithelial Na+ channel trafficking. Endocrinology 146 (2005) 5079-5085
24. Yip K.P., Tse C.M., McDonough A.A., and Marsh D.J. Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am J Physiol 275 (1998) F565-F575
25. Zhang Y., Magyar C.E., Norian J.M., et al. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am J Physiol 274 (1998) C1090-C1100
26. [published corrections appear in Am J Physiol. 1996;271(6 Pt 3):section F following table of contents and Am J Physiol. 1996;271(4 Pt 2):section F following table of contents]. Zhang Y., Mircheff A.K., Hensley C.B., et al. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol 270 (1996) F1004-F1014
27. Ellison D.H. Diuretic resistance: Physiology and therapeutics. Semin Nephrol 19 (1999) 581-597
28. Frindt G., McNair T., Dahlmann A., et al. Epithelial Na channels and short-term renal response to salt deprivation. Am J Physiol Renal Physiol 283 (2002) F717-F726
29. Khan O., Riazi S., Hu X., et al. Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone. Am J Physiol Renal Physiol 289 (2005) F442-F450
30. Na K.Y., Oh Y.K., Han J.S., et al. Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats. Am J Physiol Renal Physiol 284 (2003) F133-F143
31. Song J., Hu X., Riazi S., et al. Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. Am J Physiol Renal Physiol 290 (2006) F1055-F1064
32. McKee J.A., Kumar S., Ecelbarger C.A., et al. Detection of Na(+) transporter proteins in urine. J Am Soc Nephrol 11 (2000) 2128-2132
33. Bickel C.A., Knepper M.A., Verbalis J.G., and Ecelbarger C.A. Dysregulation of renal salt and water transport proteins in diabetic Zucker rats. Kidney Int 61 (2002) 2099-2110
34. du Cheyron D., Daubin C., Poggioli J., et al. Urinary measurement of Na+/H+ exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF. Am J Kidney Dis 42 (2003) 497-506
35. Kasiske B.L., O'Donnell M.P., and Keane W.E. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 19 Suppl 1 (1992) 1110-1115
36. Iida M., Murakami T., Ishida K., et al. Phenotypelinked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 222 (1996) 19-26
37. Bickel C.A., Verbalis J.G., Knepper M.A., and Ecelbarger C.A. Increased renal Na-K-ATPase, NCC, and betaENaC abundance in obese Zucker rats. Am J Physiol Renal Physiol 281 (2001) F639-F648
38. Walker A.B., Chattington P.D., Buckingham R.E., and Williams G. The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes 48 (1999) 1448-1453
39. Bigazzi R., Bianchi S., Batini V., et al. Metabolic risk factors and markers of cardiovascular and renal damage in overweight subjects. Am J Hypertens 19 (2006) 426-431
40. Grundy S.M. Metabolic syndrome: Therapeutic considerations. Handbook Exp Pharmacol (2005) 107-133
41. Idogun E.S., Unuigbe E.I., Famodu A.A., and Akinola O.T. Body mass index in type 2 diabetes mellitus complications: Hypertensive diabetics and diabetic nephropathy. Niger Posigrad Med J 13 170 (2006) 17-20
42. Ecelbarger C.A., Kim G.H., Terris J., et al. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279 (2000) F46-F53
43. Boini K.M., Hennige A.M., Huang D.Y., et al. Serumand glucocorticoid-inducible kinase 1 mediates salt sensitivity of glucose tolerance. Diabetes 55 (2006) 2059-2066
44. Radin M.J., Holycross B.J., Sharkey L.C., et al. Gender modulates activation of renin-angiotensin and endothelin systems in hypertension and heart failure. J Appl Physiol 92 (2002) 935-940
45. Kim G.H., Ecelbarger C.A., Mitchell C., et al. Vasopressin increases Na-K-2C1 cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol 276 (1999) F96-F103
46. Barrett-Connor E., Giardina E.G., Gitt A.K., et al. Women and heart disease: The role of diabetes and hyperglycemia. Arch Intern Med 164 (2004) 934-942
47. Howard B.V., Cowan L.D., Go O., et al. Adverse effects of diabetes on multiple cardiovascular disease risk factors in women. The Strong Heart Study. Diabetes Care 21 (1998) 1258-1265
48. Alonso-Galicia M., Brands M.W., Zappe D.H., and Hall J.E. Hypertension in obese Zucker rats. Role of angiotensin 11 and adrenergic activity. Hypertension 28 (1996) 1047-1054
49. Harker C.T., O'Donnell M.P., Kasiske B.L., et al. The reninangiotensin system in the type 11 diabetic obese Zucker rat. J Am Soc Nephrol 4 (1993) 1354-1361
50. Van Zwieten P.A., Kam K.L., Pijl A.J., et al. Hypertensive diabetic rats in pharmacological studies. Pharmacol Res 33 (1996) 95-105
51. Corry D.B., and Tuck M.L. Selective aspects of the insulin resistance syndrome. Curr Opin Nephrol Hypertens 10 (2001) 507-514
52. Melander O., Groop L., and Hulthen U.L. Effect of salt on insulin sensitivity differs according to gender and degree of salt sensitivity. Hypertension 35 (2000) 827-831
53. Pamidimukkala J., and Jandhyala B.S. Effects of salt rich diet in the obese Zucker rats: Studies on renal function during isotonic volume expansion. Clin Exp Hypertens 26 (2004) 55-67
54. Chen Y.F., Naftilan A.J., and Oparil S. Androgendependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension 19 (1992) 456-463
55. Riazi S., Khan O., Hu X., and Ecelbarger C.A. Aldosterone infusion with high-NaCl diet increases blood pressure in obese but not lean Zucker rats. Am J Physiol Renal Physiol 291 (2006) F597-F605
56. Verlander J.W., Tran T.M., Zhang L., et al. Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats. J Clin Invest 101 (1998) 1661-1669
57. Fujiwara K., Hayashi K., Matsuda H., et al. Altered pressure-natriuresis in obese Zucker rats. Hypertension 33 (1999) 1470-1475
58. Turban S., Wang X.Y., and Knepper M.A. Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: Role of NO. Am J Physiol Renal Physiol 285 (2003) F843-F851
59. Garvin J.L., and Ortiz P.A. The role of reactive oxygen species in the regulation of tubular function. Acta Physiol Scand 179 (2003) 225-232
60. Ortiz P.A., and Garvin J.L. Role of nitric oxide in the regulation of nephron transport. Am J Physiol Renal Physiol 282 (2002) F777-F784
61. Ortiz P.A., Hong N.J., and Garvin J.L. NO decreases thick ascending limb chloride absorption by reducing Na(+)-K(+)-2C1(-) cotransporter activity. Am J Physiol Renal Physiol 281 (2001) F819-F825