메뉴 건너뛰기




Volumn 33, Issue 2, 1996, Pages 95-105

Hypertensive diabetic rats in pharmacological studies

Author keywords

Cardiovascular system; Diabetes mellitus; Hypertension; Obese Zucker rats; Streptozotocin hypertensive rats

Indexed keywords

CROMAKALIM; GLIBENCLAMIDE; METHOXAMINE; NITROPRUSSIDE SODIUM; NORADRENALIN; SEROTONIN; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

EID: 0030087589     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0015     Document Type: Article
Times cited : (45)

References (44)
  • 1
    • 0001411397 scopus 로고
    • Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications
    • de Jong W, ed. Amsterdam: Elsevier
    • 1. Yamori Y. Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications. In: de Jong W, ed. Handbook of hypertension, Vol. 4. Amsterdam: Elsevier, 1984: 224-39.
    • (1984) Handbook of Hypertension , vol.4 , pp. 224-239
    • Yamori, Y.1
  • 2
    • 0000874278 scopus 로고
    • The stroke-prone spontaneously hypertensive rat: Contribution to risk factor analysis and prevention of hypertensive diseases
    • de Jong W, eds. Amsterdam: Elsevier
    • 2. Yamori Y. The stroke-prone spontaneously hypertensive rat: contribution to risk factor analysis and prevention of hypertensive diseases. In: de Jong W, eds. Handbook of hypertension, Vol. 4. Amsterdam: Elsevier, 1984: 240-55.
    • (1984) Handbook of Hypertension , vol.4 , pp. 240-255
    • Yamori, Y.1
  • 3
    • 0002089112 scopus 로고
    • Pressor mechanisms in renovascular rats
    • de Jong W, ed. Amsterdam: Elsevier
    • 3. Leenen FHH, Myers MG. Pressor mechanisms in renovascular rats. In: de Jong W, ed. Handbook of hypertension, Vol. 4. Amsterdam: Elsevier, 1984: 24-53.
    • (1984) Handbook of Hypertension , vol.4 , pp. 24-53
    • Leenen, F.H.H.1    Myers, M.G.2
  • 4
    • 0002638430 scopus 로고
    • Use of animal models in the study of diabetes
    • Kahn CR, Weir GC, eds. Philadelphia, PA: Lea & Febiger
    • 4. Karasik A, Hattori M. Use of animal models in the study of diabetes. In: Kahn CR, Weir GC, eds. Joslin's diabetes mellitus, 13th edn. Philadelphia, PA: Lea & Febiger, 1994: 217-350.
    • (1994) Joslin's Diabetes Mellitus, 13th Edn. , pp. 217-350
    • Karasik, A.1    Hattori, M.2
  • 5
    • 0011806909 scopus 로고
    • Drugs and chemicals that produce diabetes
    • 5. Fischer LJ. Drugs and chemicals that produce diabetes. Trends Pharmacol Sci 1985; 6: 72-5.
    • (1985) Trends Pharmacol Sci , vol.6 , pp. 72-75
    • Fischer, L.J.1
  • 6
    • 0020564729 scopus 로고
    • The discovery and development of the BB rat colony: An animal model of spontaneous diabetes mellitus
    • 6. Chappel CI, Chappel WR. The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus. Metabolism 1983; 32: 8-10.
    • (1983) Metabolism , vol.32 , pp. 8-10
    • Chappel, C.I.1    Chappel, W.R.2
  • 7
    • 0019785298 scopus 로고
    • Hypertensive-diabetic cardiomyopathy in the rat, an experimental model of human disease
    • 7. Factor SM, Bhan RAJ, Minase T, Wolinsky H, Sonnenblick EH. Hypertensive-diabetic cardiomyopathy in the rat, an experimental model of human disease. Am J Pathol 1981; 102: 219-28.
    • (1981) Am J Pathol , vol.102 , pp. 219-228
    • Factor, S.M.1    Bhan, R.A.J.2    Minase, T.3    Wolinsky, H.4    Sonnenblick, E.H.5
  • 8
    • 0022975099 scopus 로고
    • Depressor effect of diabetes in the spontaneously hypertensive rat: Associated changes in heart performance
    • 8. Rodgers RL. Depressor effect of diabetes in the spontaneously hypertensive rat: associated changes in heart performance. Can J Physiol Pharmacol 1986; 64: 1177-84.
    • (1986) Can J Physiol Pharmacol , vol.64 , pp. 1177-1184
    • Rodgers, R.L.1
  • 10
    • 0024405776 scopus 로고
    • The Zucker fatty rat as a genetic model of obesity and hypertension
    • 10. Kurtz TW, Morris RC, Pershadsingh HA. The Zucker fatty rat as a genetic model of obesity and hypertension. Hypertension 1989; 13: 897-901.
    • (1989) Hypertension , vol.13 , pp. 897-901
    • Kurtz, T.W.1    Morris, R.C.2    Pershadsingh, H.A.3
  • 11
    • 0017347635 scopus 로고
    • The Zucker-fatty rat: A review
    • 11. Bray GA. The Zucker-fatty rat: a review. Fed Proc 1977; 148-53.
    • (1977) Fed Proc , pp. 148-153
    • Bray, G.A.1
  • 12
    • 0026512081 scopus 로고
    • The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury
    • 12. Kasiske BL, O'Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 1992; 19: I-1 10-5.
    • (1992) Hypertension , vol.19 , Issue.I-1 , pp. 10-15
    • Kasiske, B.L.1    O'Donnell, M.P.2    Keane, W.F.3
  • 13
    • 0027195079 scopus 로고
    • The effects of hypertension and diabetes mellitus on the vascular reactivity of resistance arteries
    • 13. Hendriks MGC, Kam KL, Pijl AJ, Pfaffendorf M, van Zwieten PA. The effects of hypertension and diabetes mellitus on the vascular reactivity of resistance arteries. Blood Press 1993; 2: 69-76.
    • (1993) Blood Press , vol.2 , pp. 69-76
    • Hendriks, M.G.C.1    Kam, K.L.2    Pijl, A.J.3    Pfaffendorf, M.4    Van Zwieten, P.A.5
  • 14
    • 0027771937 scopus 로고
    • Spontaneously hypertensive rats with diabetes: Effects of some vasoconstrictors on isolated small arteries
    • 14. Kam KL, Hendriks MGC, Pijl AJ, Pfaffendorf M, van Zwieten PA. Spontaneously hypertensive rats with diabetes: effects of some vasoconstrictors on isolated small arteries. J Hypertens 1993; 11 (Suppl. 5): S120-1.
    • (1993) J Hypertens , vol.11 , Issue.SUPPL. 5
    • Kam, K.L.1    Hendriks, M.G.C.2    Pijl, A.J.3    Pfaffendorf, M.4    Van Zwieten, P.A.5
  • 16
    • 0028575405 scopus 로고
    • Streptozotocininduced diabetes mellitus in spontaneously hypertensive rats: A pathophysiological model for the combined effects of hypertension and diabetes
    • 16. Pijl AJ, van der Wal AC, Mathy MJ, Kam KL, Hendriks MGC, Pfaffendorf M, van Zwieten PA. Streptozotocininduced diabetes mellitus in spontaneously hypertensive rats: a pathophysiological model for the combined effects of hypertension and diabetes. J Pharm Methods 1994; 32: 225-33.
    • (1994) J Pharm Methods , vol.32 , pp. 225-233
    • Pijl, A.J.1    Van Der Wal, A.C.2    Mathy, M.J.3    Kam, K.L.4    Hendriks, M.G.C.5    Pfaffendorf, M.6    Van Zwieten, P.A.7
  • 17
    • 0018065039 scopus 로고
    • Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers
    • 17. Mulvany MJ, Hansen PK, Aalkjaer C. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res 1978; 43: 854-64.
    • (1978) Circ Res , vol.43 , pp. 854-864
    • Mulvany, M.J.1    Hansen, P.K.2    Aalkjaer, C.3
  • 18
    • 0018581787 scopus 로고
    • Mechanical and morphological properties of arterial resistance vessels in young and old spontaneously hypertensive rats
    • 18. Warshaw DM, Mulvany MJ, Halpern W. Mechanical and morphological properties of arterial resistance vessels in young and old spontaneously hypertensive rats. Circ Res 1979; 45: 250-9.
    • (1979) Circ Res , vol.45 , pp. 250-259
    • Warshaw, D.M.1    Mulvany, M.J.2    Halpern, W.3
  • 19
    • 0019126124 scopus 로고
    • Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats
    • 19. Mulvany MJ, Aalkjaer C, Christensen J. Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats. Hypertension 1980; 2: 664-71.
    • (1980) Hypertension , vol.2 , pp. 664-671
    • Mulvany, M.J.1    Aalkjaer, C.2    Christensen, J.3
  • 20
    • 0016304130 scopus 로고
    • Altered myocardial function and metabolism in chronic diabetes mellitus without ischemia in dogs
    • 20. Regan TJ, Ettinger PO, Kahn MI, et al. Altered myocardial function and metabolism in chronic diabetes mellitus without ischemia in dogs. Circ Res 1974; 35: 222-37.
    • (1974) Circ Res , vol.35 , pp. 222-237
    • Regan, T.J.1    Ettinger, P.O.2    Kahn, M.I.3
  • 22
    • 0021257056 scopus 로고
    • Coronary microvascular abnormalities in the hypertensive-diabetic rat, a primary cause of cardiomyopathy?
    • 22. Factor SM, Minase T, Cho S, Fein F, Capasso JM, Sonnenblick EH. Coronary microvascular abnormalities in the hypertensive-diabetic rat, a primary cause of cardiomyopathy? Am J Pathol 1984; 116: 9-20.
    • (1984) Am J Pathol , vol.116 , pp. 9-20
    • Factor, S.M.1    Minase, T.2    Cho, S.3    Fein, F.4    Capasso, J.M.5    Sonnenblick, E.H.6
  • 23
    • 0018604558 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes in the spontaneously hypertensive rat
    • 979
    • 23. Somani P, Singh HP, Saini RK, Rabinovitch A. Streptozotocin-induced diabetes in the spontaneously hypertensive rat. Metabolism 979; 28: 1075-7.
    • Metabolism , vol.28 , pp. 1075-1077
    • Somani, P.1    Singh, H.P.2    Saini, R.K.3    Rabinovitch, A.4
  • 24
    • 0023906228 scopus 로고
    • Effect of diabetes on vascular smooth muscle function in normotensive and spontaneously hypertensive rat mesenteric artery
    • 24. Agraawal DK, McNeill JH. Effect of diabetes on vascular smooth muscle function in normotensive and spontaneously hypertensive rat mesenteric artery. Can J Physiol Pharmacol 1981; 65: 2274-80.
    • (1981) Can J Physiol Pharmacol , vol.65 , pp. 2274-2280
    • Agraawal, D.K.1    McNeill, J.H.2
  • 25
    • 0026596711 scopus 로고
    • Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system
    • 25. Tomlinson KC, Gardiner SM, Hebden RA, Bennet T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol Rev 1992; 44: 103-50.
    • (1992) Pharmacol Rev , vol.44 , pp. 103-150
    • Tomlinson, K.C.1    Gardiner, S.M.2    Hebden, R.A.3    Bennet, T.4
  • 26
    • 0025331014 scopus 로고
    • Impaired calcium metabolism associated with hypertension in Zucker obese rats
    • 26. Zemel MB, Sowers JR, Shehin S, Walsh MF, Levy J. Impaired calcium metabolism associated with hypertension in Zucker obese rats. Metabolism 1990; 39: 704-8.
    • (1990) Metabolism , vol.39 , pp. 704-708
    • Zemel, M.B.1    Sowers, J.R.2    Shehin, S.3    Walsh, M.F.4    Levy, J.5
  • 27
    • 0026716392 scopus 로고
    • Metabolic abnormalities of the hyperglycemic obese Zucker rat
    • 27. McCaleb ML, Sredy J. Metabolic abnormalities of the hyperglycemic obese Zucker rat. Metabolism 1992; 41: 522-5.
    • (1992) Metabolism , vol.41 , pp. 522-525
    • McCaleb, M.L.1    Sredy, J.2
  • 28
    • 0026756329 scopus 로고
    • Cardiovascular abnormalities associated with human and rodent obesity
    • 28. Paulson DJ, Tahiliani AG. Cardiovascular abnormalities associated with human and rodent obesity. Life Sci 1992; 51: 1557-69.
    • (1992) Life Sci , vol.51 , pp. 1557-1569
    • Paulson, D.J.1    Tahiliani, A.G.2
  • 29
    • 0011850743 scopus 로고
    • Differences in blood pressure, heart rate and vascular reactivity in the obese and lean Zucker rat
    • 29. Johnson IR, Curwen JO, Wilbraham JM, Hatton R. Differences in blood pressure, heart rate and vascular reactivity in the obese and lean Zucker rat. Br J Pharmacol 1994; 112 (Suppl.): 200P.
    • (1994) Br J Pharmacol , vol.112 , Issue.SUPPL.
    • Johnson, I.R.1    Curwen, J.O.2    Wilbraham, J.M.3    Hatton, R.4
  • 30
    • 0011806911 scopus 로고
    • Vascular reactivity in hypertension: Importance of structural influences
    • 30. Folkow B, Karlstrom G. Vascular reactivity in hypertension: importance of structural influences. J Cardiovasc Pharmacol 1987; 10 (Suppl. 4): 525-30.
    • (1987) J Cardiovasc Pharmacol , vol.10 , Issue.SUPPL. 4 , pp. 525-530
    • Folkow, B.1    Karlstrom, G.2
  • 31
    • 0025334204 scopus 로고
    • Structural factor in primary and secondary hypertension
    • 31. Folkow B. Structural factor in primary and secondary hypertension. Hypertension 1990; 16: 89-100.
    • (1990) Hypertension , vol.16 , pp. 89-100
    • Folkow, B.1
  • 32
    • 0002889542 scopus 로고
    • α-adrenoceptors in blood vessels of the human forearm
    • 32. Jie K, van Brummelen P, van Zwieten PA. α-adrenoceptors in blood vessels of the human forearm. Prog Pharmacol 1986; 6: 37-45.
    • (1986) Prog Pharmacol , vol.6 , pp. 37-45
    • Jie, K.1    Van Brummelen, P.2    Van Zwieten, P.A.3
  • 33
    • 0026347506 scopus 로고
    • Adrenergic and muscarinic receptors. Classification, pathophysiological relevance and drug target
    • 33. van Zwieten PA. Adrenergic and muscarinic receptors. Classification, pathophysiological relevance and drug target. J Hypertens 1991; 9 (Suppl. 6): S18-27.
    • (1991) J Hypertens , vol.9 , Issue.SUPPL. 6
    • Van Zwieten, P.A.1
  • 35
    • 0028173218 scopus 로고
    • Drug-induced endothelium dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats
    • 35. Kam KL, Pfaffendorf M, van Zwieten PA. Drug-induced endothelium dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats. Blood Press 1994; 3: 418-27.
    • (1994) Blood Press , vol.3 , pp. 418-427
    • Kam, K.L.1    Pfaffendorf, M.2    Van Zwieten, P.A.3
  • 36
    • 0029583446 scopus 로고
    • Contractile responses to various inotropic agents in isolated hearts obtained from hypertensive diabetic rats
    • 36. Beenen OHM, Pfaffendorf M, van Zwieten PA. Contractile responses to various inotropic agents in isolated hearts obtained from hypertensive diabetic rats. Blood Press 1995; 4: 372-8.
    • (1995) Blood Press , vol.4 , pp. 372-378
    • Beenen, O.H.M.1    Pfaffendorf, M.2    Van Zwieten, P.A.3
  • 38
    • 0028047753 scopus 로고
    • Anti-ischemic effects of nifedipine in isolated working heart preparations of healthy, diabetic and hypertensive rats
    • 38. Pijl AJ, Hendriks MGC, Kam KL, Pfaffendorf M, van Zwieten PA. Anti-ischemic effects of nifedipine in isolated working heart preparations of healthy, diabetic and hypertensive rats. J Cardiovasc Pharmacol 1994; 23: 379-86.
    • (1994) J Cardiovasc Pharmacol , vol.23 , pp. 379-386
    • Pijl, A.J.1    Hendriks, M.G.C.2    Kam, K.L.3    Pfaffendorf, M.4    Van Zwieten, P.A.5
  • 39
    • 0028183683 scopus 로고
    • Effects of R 56865 on postischemic ventricular function in isolated rat working heart preparations obtained from healthy, diabetic and hypertensive animals
    • 39. Pijl AJ, Hendriks MGC, Kam KL, Pfaffendorf M, van Zwieten PA. Effects of R 56865 on postischemic ventricular function in isolated rat working heart preparations obtained from healthy, diabetic and hypertensive animals. Naunyn-Schmiedeberg's Arch Pharmacol 1994; 349: 619-26.
    • (1994) Naunyn-Schmiedeberg's Arch Pharmacol , vol.349 , pp. 619-626
    • Pijl, A.J.1    Hendriks, M.G.C.2    Kam, K.L.3    Pfaffendorf, M.4    Van Zwieten, P.A.5
  • 41
    • 0029760953 scopus 로고    scopus 로고
    • Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive diabetic rats
    • in press
    • 41. Kam KL, Pfaffendorf M, van Zwieten PA. Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive diabetic rats. Fundam Clin Pharmacol 1996; in press.
    • (1996) Fundam Clin Pharmacol
    • Kam, K.L.1    Pfaffendorf, M.2    Van Zwieten, P.A.3
  • 42
    • 0026652720 scopus 로고
    • Age-related changes in thoracic aorta of obese Zucker rats
    • 42. Cox RH, Kikta DC. Age-related changes in thoracic aorta of obese Zucker rats. Am J Physiol 1992; 262: H1584-H1556.
    • (1992) Am J Physiol , vol.262
    • Cox, R.H.1    Kikta, D.C.2
  • 43
    • 0024949709 scopus 로고
    • Increased influence of endothelium in obese Zucker rat aorta
    • 43. Auget M, Delaflotte S, Braquet P. Increased influence of endothelium in obese Zucker rat aorta. J Pharm Pharmacol 1989; 41: 861-4.
    • (1989) J Pharm Pharmacol , vol.41 , pp. 861-864
    • Auget, M.1    Delaflotte, S.2    Braquet, P.3
  • 44
    • 0026524962 scopus 로고
    • Hypertension in insulin-resistance Zucker obese rats is independent of sympathetic neural support
    • 44. Zemel MB, Peuler JD, Sowers JR, Simpson L. Hypertension in insulin-resistance Zucker obese rats is independent of sympathetic neural support. Am J Physiol 1992; 262: E368-73.
    • (1992) Am J Physiol , vol.262
    • Zemel, M.B.1    Peuler, J.D.2    Sowers, J.R.3    Simpson, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.