Gender differences in superoxide generation in microvessels of hypertensive rats: Role of NAD(P)H-oxidase

Cardiovascular Research

Volumn 61, Issue 1, 2004, Pages 22-29

  Dantas, Ana Paula V ^a   Franco, Maria Do Carmo P ^a   Silva Antonialli, Michele M ^a   Tostes, Rita C A ^a   Fortes, Zuleica B ^a   Nigro, Dorothy ^a   Carvalho, Maria Helena C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin II; Endothelial function; Gender; Hypertension; NAD(P)H oxidase; Nitric oxide; Oxygen radical

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; DICLOFENAC; DIPHENYLIODONIUM SALT; GLYCOPROTEIN GP 91; LOSARTAN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN P22; PROTEIN P47; PROTEIN P67; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME SUBUNIT; FEMALE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MICROVASCULATURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE;

ACTINS; ANGIOTENSIN II; ANIMALS; ARTERIOLES; ENDOTHELIUM, VASCULAR; FEMALE; GENDER IDENTITY; HYPERTENSION; MALE; MICROSCOPY, FLUORESCENCE; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, INBRED SHR; SUPEROXIDES;

EID: 0348240987     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.10.010     Document Type: Article

References (32)

1. Lerner D.J., Kannel W.B. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am. Heart J. 111:1986;383-390.
2. Kannel W.B. The Framingham Study: historical insight on the impact of cardiovascular risk factors in men versus women. J. Gend. Specif. Med. 5:2002;27-37.
3. Burt V.L., Whelton P., Roccella E.J.et al. Prevalence of hypertension in the US adult population: results from the third national health and nutrition examination survey, 1988-1991. Hypertension. 25:1995;305-313.
4. Chen Y.F., Meng Q.M. Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependent. Life Sci. 48:1991;85-96. [Crofton JT, Ota M, Share L].
5. Ouchi Y., Share L., Crofton J.T., Iitake K., Brooks D.P. Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension. 9:1987;172-177.
6. Rowland N.E., Fregly M.J. Role of gonadal hormones in hypertension in the Dahl salt-sensitive rat. Clin. Exp. Hypertens. A14:1992;367-375.
7. Ashton N., Balment R.J. Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive rats. Acta Endocrinol. (Copenh.). 124:1991;91-97.
8. Kauser K., Rubanyi G.M. Gender differences in endothelial dysfunction in the aorta of spontaneously hypertensive rats. Hypertension. 25:1995;517-523.
9. Kahonen M., Tolvanen J.P., Sallinen K., Wu X., Porsti I. Influence of gender on control of arterial tone in experimental hypertension. Am. J. Physiol. 275:1998;H15-H22.
10. Knot H.J., Lounsbury K.M., Brayden J.E., Nelson M.T. Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity. Am. J. Physiol. 276:1999;H961-H969.
11. Franco M., Arruda R., Dantas A.P.et al. Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring. Cardiovasc. Res. 56:2002;145-153.
12. McIntyre M., Hamilton C.A., Rees D.D., Reid J.L., Dominiczak A.F. Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension. Hypertension. 30:1997;1517-1524.
13. Harrison D.G. Endothelial function and oxidant stress. Clin. Cardiol. 20:1997;II-11-II-17.
14. Panza J.A. Endothelial dysfunction in essential hypertension. Clin. Cardiol. 20(Suppl. 2):1997;II-26-II-33.
15. Cai H., Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87:2000;840-844.
16. Brandes R.P., Mugge A. Gender differences in the generation of superoxide anions in the rat aorta. Life Sci. 60:1997;391-396.
17. Kerr S., Brosnan M.J., McIntyre M., Reid J.L., Dominiczak A.F., Hamilton C.A. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension. 33:1999;1353-1358.
18. Dantas A.P.V., Tostes R.C.A., Fortes Z.B.et al. In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats. Hypertension. 39:2002;405-411.
19. Huang A., Sun D., Kaley G., Koller A. Superoxide released to high intra-arteriolar pressure reduces nitric oxide-mediated shear stress and agonist-induced dilations. Circ. Res. 83:1998;960-965.
20. Ferreiro C.R., Chagas A.C.P., Carvalho M.H.C.et al. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism. Circulation. 103:2001;2272-2276.
21. Dantas A.P.V., Igarashi J., Michel T. Sphingosine 1-phosphate and control of vascular tone. Am. J. Physiol. 284:2003;2045-2052.
22. phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ. Res. 80:1997;45-51.
23. Zalba G., Beaumont F.J., José G.S.et al. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension. 35:2001;1055-1061.
24. phox in human coronary arteries. Circulation. 100:1999;1494-1498.
25. Fukui T., Yoshiyama M., Hanatani A.et al. Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction. Biochem. Biophys. Res. Commun. 281:2001;1200-1206.
26. Zalba G., Beaumont F.J., San-José G.et al. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension. 35:2000;1055-1061.
27. Vignais P.V. The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell. Mol. Life Sci. 59:2002;1428-1459.
28. Touyz R.M., Schiffrin E.L. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 52:2000;639-672.
29. Shiose A., Sumimoto H. Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase. J. Biol. Chem. 275:2000;13793-13801.
30. Seshiah P.N., Weber D.S., Rocic P.et al. Angiotensin II stimulation of NAD(P)H oxidase activity upstream mediators. Circ. Res. 91:2002;406-413.
31. Touyz R.M., Chen X., Tabet F.et al. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ. Res. 90:2002;1205-1213.
32. Cifuentes M.E., Rey F.E., Carretero O.A., Pagano P.J. Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice. Am. J. Physiol. 279:2000;H2234-H2240.