Thyroid status affects 5-HT2A receptor modulation of breathing before, during, and following exposure of hamsters to acute intermittent hypoxia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 5, 2007, Pages

  Varney, Abrea A ^a   Schlenker, Evelyn H ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Euthyroid sick syndrome; Hypothyroid; Limb girdle muscular dystrophy

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CARBON DIOXIDE; OXYGEN; PROPYLTHIOURACIL; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BREATHING DISORDER; CONTROLLED STUDY; FACILITATION; HORMONE RECEPTOR INTERACTION; HYPOXIA; LIMB GIRDLE MUSCULAR DYSTROPHY; LIOTHYRONINE BLOOD LEVEL; LONG TERM DEPRESSION; LUNG VENTILATION; MALE; MUSCLE WEAKNESS; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; SYRIAN HAMSTER; THYROID FUNCTION; THYROID HORMONE BLOOD LEVEL;

ANIMALS; ANOXIA; ANTITHYROID AGENTS; ATMOSPHERE EXPOSURE CHAMBERS; BODY TEMPERATURE; BODY WEIGHT; CARBON DIOXIDE; CRICETINAE; MALE; MESOCRICETUS; MUSCULAR DYSTROPHIES, LIMB-GIRDLE; PROPYLTHIOURACIL; RECEPTOR, SEROTONIN, 5-HT2A; RESPIRATORY MECHANICS; THYROID GLAND;

EID: 36048993689     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00495.2007     Document Type: Article

References (55)

1. Baker T, Zabka A, Mitchell G. Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia. Respir Physiol Neurobiol 129: 25-35, 2001.
2. Baker-Herman TL, Fuller DD, Bavis RW, Zabka AG, Golder FJ, Doperalski NJ, Johnson RA, Watters JJ, Mitchell GS. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci 7: 48-55, 2004.
3. Barnes N, Sharp T. A review of central 5HT receptors and their function. Neuropharmacology 38: 1083-1152, 1999.
4. Bhargava H, Ramaro N, Gulati P. Changes in multiple opioid receptors of the brain in rats treated chronically with thyroxine. Neuropharm Ecol 28: 955-960, 1989.
5. Blessing W, Seaman B. 5-hyroxytryptamine 2A receptors regulate sympathetic nerves constricting the cutaneous vascular bed in rabbits and rats. Neuroscience 117: 939-948, 2003.
6. Campbell K. Three muscular dystrophies: loss of the cytoskeleton-extracellular matrix linkage. Cell 80: 675-679, 1995.
7. Chueh F, Chang C, Chio C, Lin M. Puerarin acts through brain serotoninergic mechanisms to induce thermal effects. J Pharm Sci 96: 420-427, 2004.
8. Claustre J, Balende C, Pujol JF. Influence of the thyroid hormone status on tyrosine hydroxylase in central and peripheral catecholaminergic structures. Neurochem Int 28: 277-281, 1996.
9. Cleare AJ, McGregor A, Chambers SM, Dawling S, O'Keane V. Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. Neuroendocrinology 64: 65-69, 1996.
10. Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson R, Coirault L, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell 98: 465-474, 1999.
11. Crosbie RH, Barresi R, Campbell KP. Loss of sarcolemma nNOS in sarcoglycan-deficient muscle. FASEB J 16: 1786-1791, 2002.
12. Crosbie RH, Heighway J, Venzke DP, Lee JC, Campbell KP. Sarcospan, the 25-kDa transmembrane component pf the dystrophin-glycoprotein complex. J Biol Chem 272: 31221-31224, 1997.
13. Currie P, Coiro C, Niyomchai T, Lira A, Farahmand F. Hypothalamic paraventricular 5-hydroxytryptamine: receptor-specific inhibition of NPY-stimulated eating and energy metabolism. Pharmacol Biochem Behav 71: 709-716, 2002.
14. Dempsey J, Olson EB, Skatrud J. Hormones and neurochemicals in the regulation of breathing. In: Handbook of Physiology: The Respiratory System. Bethesda, MD: Am Physiol Soc 1986, sect. 2, vol. II, chapt. 7, p. 181-221.
15. de Paula PM, Tolstykh G, Mifflin S. Chronic intermittent hypoxia alters NMDA and AMPA-evoked currents in NTS receiving carotid body chemoreceptor inputs. Am J Physiol Regul Integr Comp Physiol 292: R2259-R2265, 2007.
16. Duranti R, Gorini M, Gigliotti F, Spinelli A, Fanelli A, Scano G. Control of breathing in patients with severe hypothyroidism. Am J Med 95: 29-37, 1993.
17. Durbeej M, Campbell K. Muscular dystrophies involving the dystrophin-glycoprotein complex: on overview of current mouse models. Curr Opin Genet Dev 12: 349-361, 2002.
18. Finder JD, Birnkrant D, Carl J, Farber HJ, Gozal D, Iannaccone ST, Kovesi T, Kravitz RM, Panitch H, Schramm C, Schroth M, Sharma G, Sievers L, Silvestri JM, Sterni L, American Thoracic Society. Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. Am J Respir Crit Care Med 170: 456-465, 2004.
19. Fuller DD, Zabka AG, Baker TL, Mitchell GS. Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia. J Appl Physiol 90: 2001-2006, 2001.
20. Gordon CJ. Thermal biology of the laboratory rat. Physiol Behav 47: 963-991, 1989.
21. Haddad F, Qin AX, McGue SA, Baldwin KM. Thyroid receptor plasticity in striated muscle types: effects of altered thyroid state. Am J Physiol Endocrinol Metab 274: E1018-E1026, 1998.
22. Henley WN, Bellush LL, Tressler M. Bulbospinal serotoninergic activity during changes in thyroid status. Can J Physiol Pharmacol 76: 1120-1131, 1998.
23. Herman JK, O'Halloran KD, Bisgrad GE. Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats. Respir Physiol 124: 95-104, 2001.
24. Holt K, Lim L, Straub V, Venzke D, Duclos F, Anderson R, Davidson B, Campbell K. Functional rescue of the sarcoglycan complex in the BIO 14.6 hamster using δ-sarcoglycan gene transfer. Mol Cell 1: 841-848, 1998.
25. Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71: 533-554, 2002.
26. Hui AS, Striet JB, Gudelsky G, Soukhova GK, Gozal E, Beitner-Johnson D, Guo SZ, Sachleben LR Jr, Haycock JW, Gozal D, Czyzyk-Krzeska MF. Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons. Hypertension 42: 1130-1136, 2003.
27. Jha A, Sharma SK, Tandon N, Lakshmy R, Kadhiravan T, Handa KK, Gupta R, Pandey RM, Chaturvedi PK. Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism. Sleep Med 7: 55-61, 2006.
28. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277: 968-981, 1996.
29. Kinkead R, Mitchell GS. Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine. Am J Physiol Regul Integr Comp Physiol 277: R658-R666, 1999.
30. 2A receptors and the serotonin transporter protein in the rat brain. Neurosci Behav Physiol 31: 445-449, 2001.
31. Ling L, Fuller DD, Bach KB, Kinkead R, Olson EB Jr, Mitchell GS. Chronic intermittent hypoxia elicits serotonin-dependent plasticity in the central neural control of breathing. J Neurosci 21: 5381-5388, 2001.
32. 2 receptors induces malignant hyperthermia. Naunyn Schmiedebergs Arch Pharmacol 341: 483-493, 1990.
33. McGuire M, Ling L. Ventilatory long-term facilitation is greater in 1- vs. 2-mo-old awake rats. J Appl Physiol 98: 1195-1201, 2005.
34. McGuire M, Zhang Y, White D, Ling L. Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats. Am J Physiol Regul Integr Comp Physiol 286: R334-R341, 2004.
35. Mahamed S, Mitchell GS. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnea? Exp Physiol 92: 27-37, 2007.
36. Mason GA, Bondy SC, Nemeroff CB, Walker CH, Prange AJ Jr. The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain. Psychoneuroendocrinology 12: 261-270, 1987.
37. 2A receptors. Psychopharmacology (Berl) 117: 193-219, 1995.
38. Millman R, Bevilacqua J, Peterson D, Pack A. Central sleep apnea in hypothyroidism. Am Rev Respir Dis 127: 504-507, 1982.
39. Misiolek M, Marek B, Namyslowski G, Scierski W, Zwirska-Korczala K, Kazmierczak-Zagorska Z, Kajdaniuk D, Misiolek H. Sleep apnea syndrome and snoring in patients with hypothyroidism with relation to overweight. J Physiol Pharmacol 58, Suppl 1: 77-85, 2007.
40. Murakami N, Sakai Y, Ooki S. Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide. Neurosci Lett 20: 105-108, 1980.
41. 2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain Res 890: 23-31, 2001.
42. Orr W, Males J, Imes N. Myxedema and obstructive sleep apnea. Am J Med 70: 1061-1066, 1981.
43. Ostuni MA, Houssay AB, Tumilasci OR. Modulation by thyroid hormones of rat parotid amylase secretion stimulated by 5-hydroxytryptamine. Eur J Oral Sci 111: 492-496, 2003.
44. 2A antagonist mirtazapine in rat models of thermoregulation. Brain Res 1123: 135-144, 2006.
45. Peòa JM, Ramirez JM. Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro. J Neurosci 22: 11055-11064, 2002.
46. Rajagopal K, Abbrecht P, Derderian D, Pickett C, Hofeldt F, Tellis C, Zwillich C. Obstructive sleep apnea in hypothyroidism. Ann Intern Med 101: 491-494, 1984.
47. Rastogi RB, Singhal RL. The effect of thyroid hormone on serotoninergic neurones: depletion of serotonin in discrete brain areas of developing hypothyroid rats. Naunyn Schmiedebergs Arch Pharmacol 304: 9-13, 1978.
48. Schlenker EH. An evaluation of ventilation in dystrophic Syrian hamsters. J Appl Physiol 56: 914-921, 1984.
49. Schlenker EH, Burbach JA. Thyroxine affects ventilation, lung morphometry, and necrosis of diaphragm in dystrophic hamsters. Am J Physiol Regul Integr Comp Physiol 268: R770-R785, 1995.
50. Schlenker EH, Means R, Burbach JA. Naloxone stimulates oxygen consumption but not ventilation in hypothyroid hamsters. Physiol Behav 4: 655-658, 1994.
51. Singh YN, Schlenker EH, Singh BN, Burbach JA. Consequences of thyroxine treatment on diaphragm and EDL of normal and dystrophic hamsters. Can J Physiol Pharmacol 82: 345-352, 2004.
52. Skatrud J, Iber C, Ewart R, Thomas G, Rasmussen H, Schultze B. Disordered breathing during sleep in hypothyroidism. Am Rev Respir Dis 124: 325-329, 1981.
53. Turk R, Sterrenburg E, van der Wees CG, de Meijer EJ, de Menezes RX, Groh S, Campbell KP, Noguchi S, van Ommen GJ, den Dunnen JT, Hoen PA. Common pathological mechanisms in mouse models for muscular dystrophies. FASEB J 20:127-129, 2006.
54. Zabka AG, Mitchell GS, Behan M. Ageing and gonadectomy have similar effects on hypoglossal long-term facilitation in male Fischer rats. J Physiol 563: 557-568, 2005.
55. Zwillich C, Pierson D, Hofeldt F, Lufkin E, Weil J. Ventilatory control in myxedema and hypothyroidism. N Engl J Med 292: 662-665, 1975.