Time-dependent hypoxic ventilatory responses in rats: Effects of ketanserin and 5-carboxamidotryptamine

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 277, Issue 3 46-3, 1999, Pages

  Kinkead, Richard ^a,b   Mitchell, Gordon S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Episodic stimulation; Hypoglossal nerve; Modulation; Phrenic nerve; Plasticity; Respiratory control; Serotonin

Indexed keywords

5 CARBAMOYLTRYPTAMINE; KETANSERIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HYPOGLOSSAL NERVE; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; LUNG CAPACITY; MALE; MOTONEURON; NERVE CONDUCTION; NERVE EXCITABILITY; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; RESPIRATORY BURST; SEROTONIN RELEASE;

EID: 0032882950     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.277.3.r658     Document Type: Article

References (44)

1. Al-Zubaidy, Z. A., R. L. Erickson, and J. J. Greer. Serotonergic and noradrenergic effects on respiratory neural discharge in the medullary slice preparation of neonatal rats. Pflügers Arch. 431: 942-949, 1996.
2. 2-adrenergic receptors. J. Appl. Physiol. 84: 2099-2105, 1998.
3. Bach, K. B., and G. S. Mitchell. Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir. Physiol. 104: 251-260, 1996.
4. 2 adrenergic receptors. Physiologist 39: 185, 1996.
5. 2-adrenoceptor antagonism. Brain Res. 819: 25-33, 1999.
6. Bianchi, A. L., M. Denavit-Saubié, and J. Champagnat. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol. Rev. 75: 1-45, 1995.
7. Bonham, A. C. Neurotransmitters in the CNS control of breathing. Respir. Physiol. 101: 219-230, 1995.
8. Champagnat, M. D., J. L. Henry, and V. Leviel. Catecholaminergic depressant effects on bulbar respiratory mechanisms. Brain Res. 160: 57-68, 1979.
9. Coles, S. K., and T. E. Dick. Neurones in the ventrolateral pons are required for post-hypoxic frequency decline in rats. J. Physiol. (Lond.) 497: 79-94, 1996.
10. Coles, S. K., P. Ernsberger, and T. E. Dick. A role for NMDA receptors in posthypoxic frequency decline in the rat. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R1546-R1555, 1998.
11. Dick, T. E., S. K. Coles, and J. S. Jodkowski. A "pneumotaxic centre" in the ventrolateral pons of rats. In: Ventral Brainstem Mechanisms and Control Functions, edited by O. Trouth, R. Millis, H. Kiwell-Schone, and M. Schlafke. New York: Marcel Dekker, 1995, p. 723-737.
12. DiPasquale, E., A. Lindsay, J. Feldman, R. Monteau, and G. Hilaire. Serotonergic inhibition of phrenic motoneuron activity: an in vitro study in neonatal rat. Neurosci. Lett. 230: 29-32, 1997.
13. Eldridge, F. L., P. Gill-Kumar, and D. E. Millhorn. Input-output relationships of central neural circuits involved in respiration in cats. J. Physiol. (Lond.) 311: 81-95, 1981.
14. Eldridge, F. L., and D. E. Millhorn. Oscillation, gating, and memory in the respiratory control system. In: Handbook of Physiology: The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol II, pt. 1, chapt. 3, p. 93-114.
15. Errchidi, S., and R. Monteau. Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study. J. Physiol. (Lond.) 443: 477-498, 1991.
16. Erickson, J. T., and D. E. Millhorn. Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immonoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J. Comp. Neurol. 348: 161-182, 1994.
17. Fenik, V., L. Kubin, S. Okabe, A. I. Pack, and R. O. Davies. Differential sensitivity of laryngeal and pharyngeal motoneurons to iontophoretic application of serotonin. Neuroscience 81: 873-885, 1997.
18. Fregosi, R., and G. S. Mitchell. Long term facilitation of inspiratory intercostal nerve activity following repeated carotid sinus nerve stimulation in cats. J. Physiol. (Lond.) 477.3: 469-479, 1994.
19. Hayashi, F., S. K. Coles, K. B. Bach, G. S. Mitchell, and D. R. McCrimmon. Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R811-R819, 1993.
20. Hilaire, G., C. Bou, and R. Monteau. Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study. Eur. J. Pharmacol. 329: 115-120, 1997.
21. Hoyer, D., D. E. Clarke, J. R. Fozard, P. R. Hartig, G. R. Martin, E. J. Mylecharane, P. R. Saxena, and P. P. A. Humphrey. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46: 157-203, 1994.
22. Jacobs, B. L., and E. C. Azmitia. Structure and function of the brain serotonin system. Physiol. Rev. 75: 165-229, 1992.
23. Kinkead, R., K. B. Bach, and G. S. Mitchell. Evidence of heterogeneity in serotonergic modulation of phrenic and hypoglossal motor output in rats. Physiologist 39: 187, 1996.
24. Kinkead, R., and G. S. Mitchell. Serotonin modulates post-hypoxia frequency decline (PHFD) in rats (Abstract). FASEB J. 12: A780, 1998.
25. Kubin, L., H. Tojima, R. O. Davies, and A. I. Pack. Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci. Lett. 139: 243-248, 1992.
26. Lalley, P. M. The excitability and rhythm of medullary respiratory neurons in the cat are altered by the serotonin receptor agonist 5-methoxy-N,N,dimethyltryptamine. Brain Res. 648: 87-98, 1994.
27. 1A receptor-mediated modulation of medullary expiratory neurones in the cat. J. Physiol. (Lond.) 476.1: 117-130, 1994.
28. 2 receptor controlled modulation of medullary respiratory neurones in the cat. J. Physiol. (Lond.) 487.3: 653-661, 1995.
29. Lindsay, A. D., and J. L. Feldman. Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. J. Physiol. (Lond.) 461: 213-233, 1993.
30. McCrimmon, D. R., M. S. Dekin, and G. S. Mitchell. Glutamate, GABA, and serotonin in ventilatory control. In: Regulation of Breathing, edited by J. A. Dempsey and A. I. Pack. New York: Marcel Dekker, 1995, p. 151-218.
31. Millhorn, D. E., F. L. Eldridge, and T. G. Waldrop. Prolonged stimulation of respiration by a new central neural mechanism. Respir. Physiol. 41: 87-103, 1980.
32. Millhorn, D. E., F. L. Eldridge, and T. G. Waldrop. Prolonged stimulation of respiration by endogenous central serotonin. Respir. Physiol. 42: 171-198, 1980.
33. Monteau, R., D. Morin, S. Hennequin, and G. Hilaire. Differential effects of serotonin on respiratory activity of hypoglossal and cervical motoneurons: an in vitro study on the newborn rat. Neurosci. Lett. 111: 127-132, 1990.
34. Morin, D., R. Monteau, and G. Hilaire. Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study in the newborn rat. J. Physiol. (Lond.) 451: 605-629, 1992.
35. 1 receptors in the control of hypoglossal motoneurons in vivo. Sleep 19: S150-S153, 1996.
36. Powell, F. L., G. S. Mitchell, and W. K. Milsom. Time domains of the hypoxic ventilatory response. Respir. Physiol. 112: 1223-1234, 1998.
37. Richmonds, C. R., and D. W. Hudgel. Hypoglossal and phrenic motoneuron responses to serotonergic active agents in rats. Respir. Physiol. 106: 153-160, 1996.
38. Rose, D., J. Khater-Boidin, P. Toussaint, and B. Duron. Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat. Respir. Physiol. 101: 59-69, 1995.
39. Starke, K., M. Gothert, and H. Kilbinger. Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol. Rev. 69: 864-988, 1989.
40. Teppema, L. J., J. G. Veening, A. Kranenburg, A. Dahan, A. Berkenbosh, and C. Olievier. Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J. Comp. Neurol. 388: 169-190, 1997.
41. Vanhoutte, P. M., J. M. Van Neuten, J. Symoens, and P. A. Janssen. Antihypertensive properties of ketanserin. Federation Proc. 42: 182-182, 1983.
42. Wang, Z. Z., B. Dinger, S. J. Fidone, and L. J. Stensaas. Changes in tyrosine hydroxylase and substance P immonoreactivity in the cat carotid body following chronic hypoxia and denervation. Neuroscience 83: 1273-1281, 1998.
43. 1 receptors attenuates synaptic transmission to immature rat motoneurones in vitro. Brain Res. 554: 111-121, 1991.
44. Zifa, E., and G. Fillion. 5-Hydroxytryptamine receptors. Pharmacol. Rev. 44: 401-458, 1992.