Inhibitory effect of 6-formylpterin on HIF-1α protein accumulation

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 11, 2007, Pages 2181-2184

  Sommani, Piyanart ^a   Yamashita, Kouhei ^b   Miyoshi, Takashi ^b   Tsunemine, Hiroko ^b   Kodaki, Tsutomu ^a   Mori, Hiroko ^c   Hirota, Kiichi ^b   Arai, Toshiyuki ^b   Sasada, Masataka ^a   Makino, Keisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c Higashiyama Takeda Hospital   (Japan)

Author keywords

6 formylpterin; Desferrioxamine; Hypoxia inducible factor 1; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; DEFEROXAMINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PTERIN 6 ALDEHYDE; PTERIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN CONTENT; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLCYSTEINE; ANTIOXIDANTS; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL LINE, TUMOR; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; PTERINS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 36048981144     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.2181     Document Type: Article

References (14)

1. Zagorska A., Dulak J., Acta Biochim. Pol., 51, 563-585 (2004).
2. Hirota K., Semenza G. L., Biochem. Biophys. Res. Commun., 338, 610-616 (2005).
3. Semenza G. L., Biochem. Pharmacol., 59, 47-53 (2000).
4. Semenza G. L., Trends Mol. Med., 7, 345-350 (2001).
5. Mahon P. C., Hirota K., Semenza G. L., Genes Dev., 15, 2675-2686 (2001).
6. Ho V. T., Bunn H. F., Biochem. Biophys. Res. Commun., 223, 175-180 (1996).
7. Wang G. L., Semenza G. L., Blood, 82, 3610-3615 (1993).
8. Watanabe K., Arai T., Mori H., Nakao S., Suzuki T., Tajima K., Makino K., Mori K., Biochem. Biophys. Res. Commun., 233, 447-450 (1997).
9. Lowry O. H., Bessey O. A., Crawford E. J., J. Biol. Chem., 180, 399-410 (1949).
10. Kalckar H. M., Kjeldgaard N. O., Klenow H., Biochim. Biophys. Acta, 5, 586-594 (1950).
11. Arai T., Yamada H., Namba T., Mori H., Ishii H., Yamashita K., Sasada M., Makino K., Fukuda K., Biochem. Pharmacol., 67, 1185-1193 (2004).
12. Yamashita K., Arai T., Fukuda K., Mori H., Ishii H., Nishioka M., Tajima K., Makino K., Sasada M., Biochem. Biophys. Res. Commun., 289, 85-90 (2001).
13. Arai T., Endo N., Yamashita K., Sasada M., Mori H., Ishii H., Hirota K., Makino K., Fukuda K., Free Radic. Biol. Med., 30, 248-259 (2001).
14. Semenza G. L., Cell, 107, 1-3 (2001).