Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity

Journal of Clinical Investigation

Volumn 117, Issue 11, 2007, Pages 3489-3497

  Ornatowski, Wojciech ^a   Poschet, Jens F ^a,c   Perkett, Elizabeth ^a,d   Taylor Cousar, Jennifer L ^a   Deretic, Vojo ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^c SANDIA NATIONAL LABORATORIES   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; COLLAGEN; CYTOKINE; ENZYME INHIBITOR; EXOTOXIN; FURIN; FURIN INHIBITOR; GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL LINE; CELL ORGANELLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVITY; EPITHELIUM CELL; FIBROSIS; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MACROPHAGE ACTIVATION; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; RESPIRATORY EPITHELIUM; TRANS GOLGI NETWORK; TREATMENT PLANNING;

ADP RIBOSE TRANSFERASES; BACTERIAL TOXINS; CELL LINE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EXOTOXINS; FEEDBACK, BIOCHEMICAL; FURIN; HUMANS; MACROPHAGES; NITRIC OXIDE SYNTHASE TYPE II; RESPIRATORY MUCOSA; TRANS-GOLGI NETWORK; TRANSFORMING GROWTH FACTOR BETA; VIRULENCE FACTORS;

EID: 36048932954     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI31499     Document Type: Article

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