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Volumn 64, Issue 2, 1996, Pages 524-527

Furin regulates both the activation of Pseudomonas exotoxin A and the quantity of the toxin receptor expressed on target cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; FURIN; LOW DENSITY LIPOPROTEIN; PSEUDOMONAS EXOTOXIN;

EID: 0030051747     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.2.524-527.1996     Document Type: Article
Times cited : (30)

References (29)
  • 1
    • 0022540281 scopus 로고
    • Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-angstrom resolution
    • Allured, V. S., R. J. Collier, S. F. Carroll, and D. B. McKay. 1986. Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-angstrom resolution Proc. Natl. Acad. Sci. USA 83:1320-1324.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 1320-1324
    • Allured, V.S.1    Collier, R.J.2    Carroll, S.F.3    McKay, D.B.4
  • 2
    • 0025733702 scopus 로고
    • Mammalian subtilisins the long-sought dibasic processing endoproteases
    • Barr, P. J. 1991 Mammalian subtilisins the long-sought dibasic processing endoproteases. Cell 66:1-3
    • (1991) Cell , vol.66 , pp. 1-3
    • Barr, P.J.1
  • 4
    • 0028304478 scopus 로고
    • Cleavage of Pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver
    • Chiron, M. F., C. M. Fryling, and D. J. FitzGerald. 1994. Cleavage of Pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver. J Biol. Chem. 269:18167-18176
    • (1994) J Biol. Chem. , vol.269 , pp. 18167-18176
    • Chiron, M.F.1    Fryling, C.M.2    FitzGerald, D.J.3
  • 6
    • 0026353962 scopus 로고
    • Characterization of a cellular protease that cleaves Pseudomonas exotoxin
    • Fryling, C., M. Ogata, and D. FitzGerald. 1992. Characterization of a cellular protease that cleaves Pseudomonas exotoxin. Infect. Immun 60:497-502
    • (1992) Infect. Immun , vol.60 , pp. 497-502
    • Fryling, C.1    Ogata, M.2    Fitzgerald, D.3
  • 7
    • 0028961149 scopus 로고
    • Furin-induced cleavage and activation of Shiga toxin
    • Garred, O., B. van Deurs, and K. Sandvig. 1995. Furin-induced cleavage and activation of Shiga toxin. J Biol Chem. 270:10817-10821
    • (1995) J Biol Chem. , vol.270 , pp. 10817-10821
    • Garred, O.1    Van Deurs, B.2    Sandvig, K.3
  • 8
    • 0028872463 scopus 로고
    • Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases
    • Gordon, V. M., K. R. Klimpel, N. Arora, M. A. Henderson, and S. H. Leppla. 1995. Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82-87
    • (1995) Infect. Immun. , vol.63 , pp. 82-87
    • Gordon, V.M.1    Klimpel, K.R.2    Arora, N.3    Henderson, M.A.4    Leppla, S.H.5
  • 9
    • 0028089159 scopus 로고
    • Proteolytic activation of bacterial toxins: Role of bacterial and host cell proteases Infect
    • Gordon, V. M., and S. H. Leppla. 1994. Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases Infect. Immun. 62:333-340.
    • (1994) Immun. , vol.62 , pp. 333-340
    • Gordon, V.M.1    Leppla, S.H.2
  • 10
    • 0025635768 scopus 로고
    • Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells
    • Hatsuzawa, K., M. Hosaka, T. Nakagawa, M. Nagase, A. Shoda, K. Murakami, and K. Nakayama. 1990. Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells J Biol Chem 265:22075-22078.
    • (1990) J Biol Chem , vol.265 , pp. 22075-22078
    • Hatsuzawa, K.1    Hosaka, M.2    Nakagawa, T.3    Nagase, M.4    Shoda, A.5    Murakami, K.6    Nakayama, K.7
  • 11
    • 0025369190 scopus 로고
    • Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment
    • Herz, J., R. C. Kowal, J. L. Goldstein, and M. S. Brown. 1990. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment EMBO J 9:1769-1776.
    • (1990) EMBO J , vol.9 , pp. 1769-1776
    • Herz, J.1    Kowal, R.C.2    Goldstein, J.L.3    Brown, M.S.4
  • 12
    • 0028091725 scopus 로고
    • Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro
    • Inocencio, N. M., J. M. Moehring, and T. J. Moehring. 1994. Furin activates Pseudomonas exotoxin A by specific cleavage in vivo and in vitro. J Biol. Chem. 269:31831-31835.
    • (1994) J Biol. Chem. , vol.269 , pp. 31831-31835
    • Inocencio, N.M.1    Moehring, J.M.2    Moehring, T.J.3
  • 13
    • 0026498189 scopus 로고
    • Anthrax toxin protective antigen is activated by a cell-surface protease with the sequence specificity and catalytic properties of furin
    • Klimpel, K. R., S. S. Molloy, G. Thomas, and S. H. Leppla. 1992. Anthrax toxin protective antigen is activated by a cell-surface protease with the sequence specificity and catalytic properties of furin. Proc Natl. Acad. Sci. USA 89:10277-10281.
    • (1992) Proc Natl. Acad. Sci. USA , vol.89 , pp. 10277-10281
    • Klimpel, K.R.1    Molloy, S.S.2    Thomas, G.3    Leppla, S.H.4
  • 14
    • 0026690341 scopus 로고
    • The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A
    • Kounnas, M. Z., R. E. Morris, M. R. Thompson, D. J. FitzGerald, D. K. Strickland, and C. B. Saelinger. 1992. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J. Biol. Chem. 267:12420-12423.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12420-12423
    • Kounnas, M.Z.1    Morris, R.E.2    Thompson, M.R.3    FitzGerald, D.J.4    Strickland, D.K.5    Saelinger, C.B.6
  • 15
    • 0026095523 scopus 로고
    • Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3
    • Misumi, Y., K. Oda, T. Fujiwara, N. Takami, K. Tashiro, and Y. Ikehara. 1991. Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3. J. Biol. Chem. 266:16954-16959.
    • (1991) J. Biol. Chem. , vol.266 , pp. 16954-16959
    • Misumi, Y.1    Oda, K.2    Fujiwara, T.3    Takami, N.4    Tashiro, K.5    Ikehara, Y.6
  • 16
    • 0027452932 scopus 로고
    • Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion
    • Moehring, J. M., N. M. Inocencio, B. J. Robertson, and T. J. Maehring. 1993. Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion. J. Biol. Chem. 268:2590-2594.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2590-2594
    • Moehring, J.M.1    Inocencio, N.M.2    Robertson, B.J.3    Maehring, T.J.4
  • 17
    • 0020561771 scopus 로고
    • Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses
    • Moehring, J. M., and T. J. Moehring. 1983 Strains of CHO-K1 cells resistant to Pseudomonas exotoxin A and cross-resistant to diphtheria toxin and viruses. Infect. Immun. 41:998-1009.
    • (1983) Infect. Immun. , vol.41 , pp. 998-1009
    • Moehring, J.M.1    Moehring, T.J.2
  • 18
    • 0019061918 scopus 로고
    • Ligand: A versatile computerized approach for characterization of ligand-binding systems
    • Munson, P. J., and D. Rodbard. 1980 Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107:220-239.
    • (1980) Anal. Biochem. , vol.107 , pp. 220-239
    • Munson, P.J.1    Rodbard, D.2
  • 19
    • 0025243542 scopus 로고
    • Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol
    • Ogata, M., V. K. Chaudhary, I. Pastan, and D. J. FitzGerald. 1990. Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol. J. Biol. Chem. 265:20678-20685.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20678-20685
    • Ogata, M.1    Chaudhary, V.K.2    Pastan, I.3    Fitzgerald, D.J.4
  • 20
    • 0026455183 scopus 로고
    • Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol
    • Ogata, M., C. M. Fryling, I. Pastan, and D. J. FitzGerald. 1992. Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol. J Biol. Chem. 267:25396-25401
    • (1992) J Biol. Chem. , vol.267 , pp. 25396-25401
    • Ogata, M.1    Fryling, C.M.2    Pastan, I.3    FitzGerald, D.J.4
  • 21
    • 0024433513 scopus 로고
    • Pseudomonas exotoxin: Chimeric toxins
    • Pastan, I., and D. FitzGerald. 1989. Pseudomonas exotoxin: chimeric toxins. J. Biol Chem 264:15157-15160
    • (1989) J. Biol Chem , vol.264 , pp. 15157-15160
    • Pastan, I.1    FitzGerald, D.2
  • 22
    • 0029071584 scopus 로고
    • Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin
    • Schafer, W., A. Stroh, S. Berghoter, J. Seiler, M. Vey, M. L. Kruse, H. F. Kern, H. D. Klenk, and W. Garten. 1995. Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin. EMBO J. 14:2424-2435.
    • (1995) EMBO J. , vol.14 , pp. 2424-2435
    • Schafer, W.1    Stroh, A.2    Berghoter, S.3    Seiler, J.4    Vey, M.5    Kruse, M.L.6    Kern, H.F.7    Klenk, H.D.8    Garten, W.9
  • 23
    • 0023056546 scopus 로고
    • Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA
    • Tokunaga, K., H. Taniguchi, K. Yoda, M. Shimizu, and S. Sakiyama. 1986. Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA. Nucleic Acids Res 14:2829.
    • (1986) Nucleic Acids Res , vol.14 , pp. 2829
    • Tokunaga, K.1    Taniguchi, H.2    Yoda, K.3    Shimizu, M.4    Sakiyama, S.5
  • 24
    • 0027495717 scopus 로고
    • Evidence for involvement of furin in cleavage and activation of diphtheria toxin
    • Tsuneoka, M., K. Nakayama, K. Hatsuzawa, M. Komada, N. Kitamura, and E. Mekada. 1993 Evidence for involvement of furin in cleavage and activation of diphtheria toxin J. Biol Chem. 268:26461-26465.
    • (1993) J. Biol Chem. , vol.268 , pp. 26461-26465
    • Tsuneoka, M.1    Nakayama, K.2    Hatsuzawa, K.3    Komada, M.4    Kitamura, N.5    Mekada, E.6
  • 25
    • 0027354037 scopus 로고
    • Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases
    • van de Ven, W. J., A. J. Roebroek, and H. L. van Duijnhoven. 1993 Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases Crit. Rev. Oncog. 4:115-136.
    • (1993) Crit. Rev. Oncog. , vol.4 , pp. 115-136
    • Van De Ven, W.J.1    Roebroek, A.J.2    Van Duijnhoven, H.L.3
  • 26
    • 0025866211 scopus 로고
    • A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2
    • Watson, D. G., J. M. Moehring, and T. J. Moehring. 1991. A mutant CHO-K1 strain with resistance to Pseudomonas exotoxin A and alphaviruses fails to cleave Sindbis virus glycoprotein PE2. J Virol. 65:2332-2339.
    • (1991) J Virol. , vol.65 , pp. 2332-2339
    • Watson, D.G.1    Moehring, J.M.2    Moehring, T.J.3
  • 27
    • 0025185583 scopus 로고
    • Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A
    • Wick, M. J., D. W. Frank, D. G. Storey, and B. H. Iglewski. 1990 Structure, function, and regulation of Pseudomonas aeruginosa exotoxin A. Annu. Rev. Microbiol. 44:335-363.
    • (1990) Annu. Rev. Microbiol. , vol.44 , pp. 335-363
    • Wick, M.J.1    Frank, D.W.2    Storey, D.G.3    Iglewski, B.H.4
  • 28
    • 0026793036 scopus 로고
    • A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein Multiple regulatory sites for 39-kDa receptor-associated protein
    • Williams, S. E., J. D. Ashcom, W. S. Argraves, and D. K. Strickland. 1992 A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein Multiple regulatory sites for 39-kDa receptor-associated protein. J. Biol. Chem. 267:9035-9040.
    • (1992) J. Biol. Chem. , vol.267 , pp. 9035-9040
    • Williams, S.E.1    Ashcom, J.D.2    Argraves, W.S.3    Strickland, D.K.4
  • 29
    • 0028343888 scopus 로고
    • Genetic deficiency in low density lipoprotein receptor-related protein confers cellular-resistance to Pseudomonas exotoxin A: Evidence that this protein is required for uptake and degradation of multiple ligands
    • Willnow, T. E., and J. Herz. 1994. Genetic deficiency in low density lipoprotein receptor-related protein confers cellular-resistance to Pseudomonas exotoxin A: evidence that this protein is required for uptake and degradation of multiple ligands. J. Cell Sci. 107:719-726.
    • (1994) J. Cell Sci. , vol.107 , pp. 719-726
    • Willnow, T.E.1    Herz, J.2


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