Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects

Environment International

Volumn 32, Issue 6, 2006, Pages 749-757

  Bláha, Luděk ^a   Hilscherová, Klára ^a   Mazurová, Edita ^a   Hecker, Markus ^b   Jones, Paul D ^b   Newsted, John L ^c   Bradley, Patrick W ^b   Gracia, Tannia ^b   Ďuriš, Zdenek ^d   Horká, Ivona ^d   Holoubek, Ivan ^a   Giesy, John P ^b,e  

^a MASARYK UNIVERSITY   (Czech Republic)

^b National Food Safety and Toxicology Center   (United States)

^c ENTRIX INC   (United States)

^d UNIVERSITY OF OSTRAVA   (Czech Republic)

^e CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

AhR; Arylhydrocarbon receptor; Coal sediment; Crayfish; Dioxin; ER; Estrogen receptor; H295R; Intersex; Pontastacus (= Astacus) leptodactylus; Steroidogenesis

Indexed keywords

BIOASSAY; BIOCIDES; CELLS; CHLORINE CONTAINING POLYMERS; GENES; IMPURITIES; ORGANIC COMPOUNDS; SULFURIC ACID;

ARYLHYDROCARBON RECEPTOR; COAL SEDIMENT; CRAYFISH; DIOXIN; ESTROGEN RECEPTOR; H295R; INTERSEX; PONTASTACUS (= ASTACUS) LEPTODACTYLUS; STEROIDOGENESIS;

ENDOCRINOLOGY;

ALDOSTERONE SYNTHASE; AROMATASE; CYTOCHROME P450 11A; CYTOCHROME P450 17; ENDOCRINE DISRUPTOR; ENZYME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ORGANOCHLORINE PESTICIDE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCYCLIC AROMATIC HYDROCARBON; STEROID 21 MONOOXYGENASE; STEROID HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; SULFURIC ACID; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

BIOASSAY; CHEMICAL POLLUTANT; CRAYFISH; ENDOCRINE DISRUPTOR; GENE EXPRESSION; ORGANOCHLORINE; PAH; PCB; PESTICIDE RESIDUE; STEROID; TOXICITY;

ANIMAL CELL; ARTICLE; BIOASSAY; COMPARATIVE STUDY; CONTAMINATION; CONTROLLED STUDY; CRAYFISH; CRUSTACEA; CZECH REPUBLIC; ENVIRONMENT; GENE EXPRESSION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEDIMENT; STATISTICAL SIGNIFICANCE; STEROIDOGENESIS;

CENTRAL EUROPE; CZECH REPUBLIC; EURASIA; EUROPE; KARVINA; MORAVSKOSLEZSKY; OSTRAVA;

ASTACOIDEA; CRUSTACEA; DECAPODA (CRUSTACEA); PONTASTACUS LEPTODACTYLUS;

EID: 33745430673     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2006.03.011     Document Type: Article

References (42)

1. Arcaro K.F., O'Keefe P.W., Yang Y., Clayton W., and Gierthy J.F. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology 133 (1999) 115-127
2. Augustowska K., Gregoraszczuk E.L., Grochowalski A., Milewicz T., Mika M., Krzysiek J., et al., Chrzaszcz R. Comparison of accumulation and altered steroid secretion by placental tissue treated with TCDD and natural mixture of PCDDs-PCDFs. Reproduction 126 (2003) 681-687
3. Bureik M., Lisurek M., and Bernhardt R. The human steroid hydroxylases CYP11B1 and CYP11B2. Biol Chem 383 (2002) 1537-1551
4. Burke M.D., and Mayer R.T. Ethoxyresorufin: direct fluorometric assay of microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab Dispos 2 (1974) 583-588
5. Chaloupka K., Krishnan V., and Safe S. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in Mcf-7 human breast-cancer cells - role of the Ah receptor. Carcinogenesis 13 (1992) 2233-2239
6. Connor K., Howell J., Chen I., Liu H., Berhane K., Sciarretta C., et al. Failure of chloro-s-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fundam Appl Toxicol 30 (1996) 93-101
7. Depledge M.H., and Billinghurst Z. Ecological significance of endocrine disruption in marine invertebrates. Mar Pollut Bull 39 (1999) 32-38
8. Gazdar A.F., Oie H.K., Shackleton C.H., Chen T.R., Triche T.J., Myers C.E., et al. Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res 50 (1990) 5488-5496
9. Gray L.E., Kelce W.R., Wiese T., Tyl R., Gaido K., Cook J., et al. Endocrine screening methods workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol 11 (1997) 719-750
10. Harvey P.W., and Everett D.J. The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?. J Appl Toxicol 23 (2003) 81-87
11. Hilscherova K., Machala M., Kannan K., Blankenship A.L., and Giesy J.P. Cell bioassay for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samples - review. Environ Sci Pollut Res 7 (2000) 159-171
12. Hilscherova K., Kannan K., Kang Y.S., Holoubek I., Machala M., Masunaga S., et al. Characterization of dioxin-like activity of sediments from a Czech river basin. Environ Toxicol Chem 20 (2001) 2768-2777
13. Hilscherova K., Kannan K., Holoubek I., and Giesy J.P. Characterization of estrogenic activity of riverine sediments from the Czech Republic. Arch Environ Contam Toxicol 43 (2002) 175-185
14. Hilscherova K., Jones P.D., Gracia T., Newsted J.L., Zhang X.W., Sanderson J.T., et al. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol Sci 81 (2004) 78-89
15. Houtman C.J., Cenijn P.H., Hamers T., Lamoree M.H., Legler J., Murk A.J., et al. Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption. Environ Toxicol Chem 23 (2004) 32-40
16. Hudson K.E., Wickings E.J., and Hillier S.G. Effects of 2-hydroxyoestradiol, oestradiol and testosterone on fish-induction of catecholamine- and gonadotrophin-responsive progesterone biosynthesis in rat granulosa cell cultures. J Steroid Biochem 28 (1987) 267-272
17. Jana N.R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., and Sone H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochem Biophys Res Commun 256 (1999) 462-468
18. Khim J.S., Lee K.T., Kannan K., Villeneuve D., Giesy J.P., and Koh C.H. Trace organic contaminants in sediment and water from Ulsan Bay and its vicinity, Korea. Arch Environ Contam Toxicol 40 (2001) 141-150
19. Klamer H.J.C., Leonards P.E.G., Lamoree M.H., Villerius L.A., Akerman J.E., and Bakker J.F. A chemical and toxicological profile of Dutch North Sea surface sediments. Chemosphere 58 (2005) 1579-1587
20. Ladewig V., Jungmann D., Koehler A., Schirling M., Triebskorn R., and Nagel R. Intersexuality in Gammarus fossarum Koch, 1835 (Amphipoda). Crustaceana 75 (2002) 1289-1299
21. LaFont R. The endocrinology of invertebrates. Ecotoxicology 9 (2000) 41-57
22. Li L.A., Wang P.W., and Chang L.W. Polychlorinated biphenyl 126 stimulates basal and inducible aldosterone biosynthesis of human adrenocortical H295R cells. Toxicol Appl Pharmacol 195 (2004) 92-102
23. Lindhe O., Granberg L., and Brandt I. Target cells for cytochrome P450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands. Arch Toxicol 76 (2002) 460-466
24. Machala M., Vondracek J., Blaha L., Ciganek M., and Neca J. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutat Res/Gen Toxicol Environ Mutagen 497 (2001) 49-62
25. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
26. Murk A.J., Legler J., Denison M.S., Giesy J.P., vandeGuchte C., and Brouwer A. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam Appl Toxicol 33 (1996) 149-160
27. Nakajin S., Shinoda S., Ohno S., Nakazawa H., and Makino T. Effect of phthalate esters and alkylphenols on steroidogenesis in human adrenocortical H295R cells. Environ Toxicol Pharmacol 10 (2001) 103-110
28. Nativelle-Serpentini C., Richard S., Seralini G.-E., and Sourdaine P. Aromatase activity modulation by lindane and bisphenol-A in human placental JEG-3 and transfected kidney E293 cells. Toxicol in Vitro 17 (2003) 413-422
29. Oberdorster E., Cottam D.M., Wilmot F.A., Milner M.J., and McLachlan J.A. Interaction of PAHs and PCBs with ecdysone-dependent gene expression and cell proliferation. Toxicol Appl Pharmacol 160 (1999) 101-108
30. Pinn E.H., Atkinson R.J.A., and Rogerson A. Sexual dimorphism and intersexuality in Upogebia stellata (Crustacea : Decapoda : Thalassinidea). J Mar Biol Assoc UK 81 (2001) 1061-1062
31. Rudolph E.H. Partial protandric hermaphroditism in the burrowing crayfish Parastacus-nicoleti (Philippi, 1882) (Decapoda, Parastacidae). J Crustac Biol 15 (1995) 720-732
32. Safe S., Wang F., Porter W., Duan R., and McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol Lett 103 (1998) 343-347
33. Sagi A., Snir E., and Khalaila I. Sexual differentiation in decapod crustaceans: role of the androgenic gland. Invertebr Reprod Dev 31 (1997) 55-61
34. Sanderson J.T., Seinen W., Giesy J.P., and van den Berg M. 2-chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?. Toxicol Sci 54 (2000) 121-127
35. Sanderson J.T., Slobbe L., Lansbergen G.W.A., Safe S., and van den Berg M. 2,3,7,8-tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Toxicol Sci 61 (2001) 40-48
36. Sanderson J.T., Boerma J., Lansbergen G.W.A., and van den Berg M. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol 182 (2002) 44-54
37. Sugawara T., Nomura E., Sakuragi N., and Fujimoto S. The effect of the arylhydrocarbon receptor on the human steroidogenic acute regulatory gene promoter activity. J Steroid Biochem Mol Biol 78 (2001) 253-260
38. Sumpter J.P., and Johnson A.C. Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment. Environ Sci Technol 39 (2005) 4321-4332
39. Tan Z., Chang X., Puga A., and Xia Y. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 64 (2002) 771-780
40. Van den Berg M., Birnbaum L., Bosveld A.T.C., Brunström B., Cook P., Feeley M., et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 106 (1998) 775-792
41. Vondráček J., Machala M., Minksová K., Bláha L., Murk A.J., Kozubík A., et al. Monitoring river sediments contaminated predominantly with polyaromatic hydrocarbons by chemical and in vitro bioassay techniques. Environ Toxicol Chem 20 (2001) 1499-1506
42. Zhang X.W., Yu R.M.K., Jones P.D., Lam G.K.W., Newsted J.L., Gracia T., et al. Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line. Environ Sci Technol 39 (2005) 2777-2785