Azole-bridged diplatinum anticancer compounds. Modulating DNA flexibility to escape repair mechanism and avoid cross resistance

Journal of Physical Chemistry B

Volumn 111, Issue 41, 2007, Pages 11873-11876

  Spiegel, Katrin ^a   Magistrato, Alessandra ^b   Carloni, Paolo ^b   Reedijk, Jan ^c   Klein, Michael L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DEMOCRITOS NATIONAL SIMULATION CENTER   (Italy)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; COMPUTER SIMULATION; CYTOTOXICITY; ENZYMES; FREE ENERGY; MOLECULAR DYNAMICS; ONCOLOGY; TUMORS;

ANTICANCER COMPOUNDS; CELL LINES; CISPLATIN; DRUG RESISTANCE; STRUCTURAL CHANGES;

DRUG PRODUCTS;

EID: 35949003524     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp0762323     Document Type: Article

References (38)

1. Reedijk, J. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3611.
2. Jamieson, E. R.; Lippard, S. J. Chem. Rev. 1999, 99, 2467.
3. Brabec, V.; Kasparkova, J. Drug. Resist. Updates 2002, 5, 147.
4. van Zutphen, S.; Reedijk, J. Coord. Chem. Rev. 2005, 249, 2845.
5. Rabik, C. A.; Dolan, M. E. Cancer Treat. Rev. 2007, 33, 9.
6. Zorbas, H.; Keppler, B. K. ChemBioChem 2005, 6, 1157.
7. Wang, D.; Lippard, S. J. Nat. Rev. Drug Discovery 2005, 4, 307.
8. Ohndorf, U.; Rould, M.; He, Q.; Pabo, C.; Lippard, S. J. Nature 1999, 399, 708.
9. Cohen, S. M.; Mikata, Y.; He, Q.; Lippard, S. J. Biochemistry 2000, 39, 11771.
10. Cohen, S. M.; Lippard, S. J. Cisplatin: From DNA damage to cancer chemotherapy Prog. Nucleic Acid Res. Mol. Biol. 2001, 67, 93.
11. He, Q.; Ohndorf, U.; Lippard, S. J. Biochemistry 2000, 39, 14426.
12. Komeda, S.; Lutz, M.; Spek, A. L.; Chikuma, M.; Reedijk, J. Inorg. Chem. 2000, 39, 4230.
13. Komeda, S.; Kalayda, G. V.; Lutz, M.; Spek, A. L.; Yamanaka, Y.; Sato, T.; Chikuma, M.; Reedijk, J. J. Med. Chem. 2003, 46, 1210.
14. Komeda, S.; Bombard, S.; Perrier, S.; Reedijk, J.; Kozelka, J. J. Inorg. Biochem. 2003, 96, 357.
15. Kalayda, G. V.; Fakih, S.; Bertram, H.; Ludwig, T.; Oberleithner, H.; Krebs, B.; Reedijk, J. J. Inorg. Biochem. 2006, 100, 1332.
16. Teletchea, S.; Komeda, S.; Teuben, J. M.; Elizondo-Riojas, M. A.; Reedijk, J.; Kozelka, J. Chem-Eur. J. 2006, 12, 3741.
17. Komeda, S.; Lutz, M.; Spek, A. L.; Yamanaka, Y.; Sato, T.; Chikuma, M.; Reedijk, J. J. Am. Chem. Soc. 2002, 124, 4738.
18. Magistrato, A.; Ruggerone, P.; Spiegel, K.; Carloni, P.; Reedijk, J. J. Phys. Chem. B 2006, 110, 3604.
19. Spiegel, K.; Magistrato, A. Org. Biomol. Chem. 2006, 4, 2507.
20. Spiegel, K.; Magistrato, A.; Maurer, P.; Ruggerone, P.; Carloni, P.; Rothlisberger, U.; Reedijk, J.; Klein, M. L. J. Comput. Chem., in press.
21. Zacharias, M. Biophys. J. 2006, 91, 882.
22. Harrington, R. E. Mol. Microbiol. 1992, 6, 2549.
23. Gromiha, M. M. J. Biotechnol. 2005, 117, 137.
24. Olson, W. K.; Gorin, A. A.; Lu, X. J.; Hock, L. M.; Zhurkin, V. B. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 11163.
25. Deremble, C.; Lavery, R. Curr. Opin. Struct. Biol. 2005, 15, 171.
26. Maurer, P.; Laio, A.; Hugosson, H.; Colombo, M. C.; Rothlisberger, U. J. Chem. Theory Comput. 2007, 3, 628.
27. Chipot, C.; Henin, J. J. Chem. Phys. 2005, 123, 224906.
28. Case, D. A.; Cheatham, T. E., III; Darden, T.; 'Gohlke, H.; Luo, R.; Merz, K. M., Jr.; Onufriev, A.; Simmerling, C.; Wang, B.; Woods, R. J. J. Comput. Chem. 2005, 26, 1668.
29. Cheatham, T. E., III; Cieplak, P.; Kollman, P. A. J. Biomol Struct. Dyn. 1999, 16, 845.
30. Joergensen, W.; Chandrasekhar, J.; Madura, J.; Impey, R.; Klein, M. J. Chem. Phys. 1983, 79, 926.
31. Petrov, A. S.; Pack, G. R.; Lamm, G. J. Phys. Chem. B 2004, 108, 6072.
32. Roccatano, D.; Barthel, A.; Zacharias, M. Biopolymers 2007, 85, 407.
33. Darden, T.; York, D. L. P. J. Chem. Phys. 1993, 98, 10089.
34. Phillips, J. C.; Braun, R.; Wang, W.; Gumbart, J.; Tajkhorshid, E.; Villa, E.; Chipot, C.; Skeel, R. D.; Kale, L.; Schulten, K. J. Comput. Chem. 2005, 26, 1781.
35. Laxmikant, K.; Skeel, R.; Bhandarkar, M.; Brunner, R.; Gursoy, A.; Krawetz, N.; Phillips, J.; Shinozaki, A.; Varadarajan, K.; Schulten, K. J. Comput. Phys 1999, 151, 283.
36. Lavery, R.; Sklenar, H. J. Biomol. Struct. Dyn. 1989, 6, 655.
37. Spiegel, K.; Rothlisberger, U.; Carloni, P. J. Phys. Chem. B 2004, 708, 2699.
38. Cohen, G. L.; Bauer, W. R.; Barton, J. K.; Lippard, S. J. Science 1979, 203, 1014.