Cyr61/CCN1 is a tumor suppressor in human hepatocellular carcinoma and involved in DNA damage response

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 1, 2008, Pages 98-109

  Feng, Ping ^a   Wang, Bei ^b   Ren, Ee Chee ^a,b  

^a GENOME INSTITUTE OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cyr61; Genotoxic stress; Hepatocellular carcinoma; p53; Tumor suppressor

Indexed keywords

CYSTEINE RICH PROTEIN 61; DNA; FLUOROURACIL; PROTEIN P53; SMALL INTERFERING RNA;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ULTRAVIOLET IRRADIATION; WESTERN BLOTTING;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MIGRATION ASSAYS; CELL MOVEMENT; CELL PROLIFERATION; CYSTEINE-RICH PROTEIN 61; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; NEOPLASM INVASIVENESS; RNA, SMALL INTERFERING; SOS RESPONSE (GENETICS);

EID: 35948937180     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2007.06.020     Document Type: Article

References (43)

1. Akamatsu H., Ichihara-Tanaka K., Ozono K., Kamiike W., Matsuda H., and Sekiguchi K. Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. Cancer Res. 56 (1996) 4541-4546
2. Amundson S.A., Myers T.G., and Fornace Jr. A.J. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 17 (1998) 3287-3299
3. Appella E., and Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268 (2001) 2764-2772
4. Babic A.M., Kireeva M.L., Kolesnikova T.V., and Lau L.F. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6355-6360
5. Brenner K.A., Corbett S.A., and Schwarzbauer J.E. Regulation of fibronectin matrix assembly by activated Ras in transformed cells. Oncogene 19 (2000) 3156-3163
6. Brigstock D.R. The CCN family: a new stimulus package. J. Endocrinol. 178 (2003) 169-175
7. Carloni V., Mazzocca A., Pantaleo P., Cordella C., Laffi G., and Gentilini P. The integrin, α6β1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells. Hepatology 34 (2001) 42-49
8. Carragher N.O., and Frame M.C. Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell. Biol. 14 (2004) 241-249
9. Chen C.C., Mo F.E., and Lau L.F. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J. Biol. Chem. 276 (2001) 47329-47337
10. Chen X., Cheung S.T., So S., et al. Gene expression patterns in human liver cancers. Mol. Biol. Cell. 13 (2002) 1929-1939
11. Chen Y., Abraham D.J., Shi-Wen X., et al. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol. Biol. Cell. 15 (2004) 5635-5646
12. Chien W., Kumagai T., Miller C.W., et al. Cyr61 suppresses growth of human endometrial cancer cells. J. Biol. Chem. 279 (2004) 53087-53096
13. Clark E.A., King W.G., Brugge J.S., Symons M., and Hynes R.O. Integrin-mediated signals regulated by members of the Rho family of GTPases. J. Cell. Biol. 142 (1998) 573-586
14. 3, independent of its carboxyl-terminal domain. J. Biol. Chem. 276 (2001) 21943-21950
15. 1 and cell surface heparan sulfate proteoglycans. Endocrinology 143 (2002) 1441-1450
16. Hirasaki S., Koide N., Ujike K., Shinji T., and Tsuji T. Expression of Nov, CYR61, and CTGF genes in human hepatocellular carcinoma. Hepatol. Res. 19 (2001) 294-305
17. Holloway S.E., Beck A.W., Girard L., et al. Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer. J. Am. Coll. Surg. 200 (2005) 371-377
18. Hood J.D., and Cheresh D.A. Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2 (2002) 91-100
19. Hoshijima M., Hattori T., Inoue M., et al. CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett. 580 (2006) 1376-1382
20. 3. J. Biol. Chem. 274 (1999) 24321-24327
21. Kireeva M.L., Mo F.E., Yang G.P., and Lau L.F. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol. Cell. Biol. 16 (1996) 1326-1334
22. Leask A., and Abraham D.J. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J. Cell. Sci. 119 (2006) 4803-4810
23. Lee J.S., and Thorgeirsson S.S. Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer. Hepatology 35 (2002) 1134-1143
24. Lin M.T., Zuon C.Y., Chang C.C., et al. Cyr61 induces gastric cancer cell motility/invasion via activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 signaling pathway. Clin. Cancer Res. 11 (2005) 5809-5820
25. Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma. Lancet 362 (2003) 1907-1917
26. 3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 24 (2005) 761-779
27. Mo F.E., Muntean A.G., Chen C.C., Stolz D.B., Watkins S.C., and Lau L.F. Cyr61 (CCN1) is essential for placental development and vascular integrity. Mol. Cell. Biol. 22 (2002) 8709-8720
28. Nejjari M., Hafdi Z., Gouysse G., et al. Expression, regulation, and function of αV integrins in hepatocellular carcinoma: an in vivo and in vitro study. Hepatology 36 (2002) 418-426
29. Neo S.Y., Leow C.K., Vega V.B., et al. Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach. Hepatology 39 (2004) 944-953
30. O'Brien T.P., Yang G.P., Sanders L., and Lau L.F. Expression of cyr61, a growth factor-inducible immediate-early gene. Mol. Cell. Biol. 10 (1990) 3569-3577
31. Perbal B. CCN proteins: multifunctional signalling regulators. Lancet 363 (2004) 62-64
32. Pilarsky C.P., Schmidt U., Eissrich C., et al. Expression of the extracellular matrix signaling molecule Cyr61 is downregulated in prostate cancer. Prostate 36 (1998) 85-91
33. Ridley A.J., Schwartz M.A., Burridge K., et al. Cell migration: integrating signals from front to back. Science 302 (2003) 1704-1709
34. Sampath D., Zhu Y., Winneker R.C., and Zhang Z. Aberrant expression of Cyr61, a member of the CCN (CTGF/Cyr61/Cef10/NOVH) family, and dysregulation by 17β-estradiol and basic fibroblast growth factor in human uterine leiomyomas. J. Clin. Endocrinol. Metab. 86 (2001) 1707-1715
35. Spence H.J., McGarry L., Chew C.S., et al. AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Mol. Cell. Biol. 26 (2006) 1480-1495
36. Thomas M.B., and Zhu A.X. Hepatocellular carcinoma: the need for progress. J. Clin. Oncol. 23 (2005) 2892-2899
37. Tong X., O'Kelly J., Xie D., et al. Cyr61 suppresses the growth of non-small-cell lung cancer cells via the β-catenin-c-myc-p53 pathway. Oncogene 23 (2004) 4847-4855
38. Tong X., Xie D., O'Kelly J., Miller C.W., Muller-Tidow C., and Koeffler H.P. Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer. J. Biol. Chem. 276 (2001) 47709-47714
39. Tsai M.S., Bogart D.F., Castañeda J.M., Li P., and Lupu R. Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene 21 (2002) 8178-8185
40. Wang B., Ren J., Ooi L.L., Chong S.S., and Lee C.G. Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients. Oncogene 24 (2005) 3999-4008
41. Xie D., Yin D., Tong X., et al. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and β-catenin-TCF/Lef signaling pathways. Cancer Res. 64 (2004) 1987-1996
42. Xu L., Hui L., Wang S., et al. Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma. Cancer Res. 61 (2001) 3176-3181
43. Zeng Z.J., Yang L.Y., Ding X., and Wang W. Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance. World J. Gastroenterol. 10 (2004) 3414-3418