Dipeptidyl-α,β-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 24, 2007, Pages 6697-6700

  González, Florenci V ^a   Izquierdo, Javier ^a   Rodríguez, Santiago ^a   McKerrow, James H ^b   Hansell, Elizabeth ^b  

^a UNIVERSITAT JAUME I   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cysteine proteases inhibitors; Dipeptides; Epoxides; Epoxyesters

Indexed keywords

ALOXISTATIN ACID; CATHEPSIN B; CRUZIPAIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE DERIVATIVE; EPOXIDE; ESTER DERIVATIVE; K 11777; RHODESAIN; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY; TRYPANOSOMA BRUCEI;

ANIMALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; EPOXY COMPOUNDS; ESTERS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STEREOISOMERISM; TRYPANOSOMA BRUCEI BRUCEI;

EID: 35848959471     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.056     Document Type: Article

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24. obs for solvent, at the highest concentration tested.