메뉴 건너뛰기




Volumn 19, Issue 6, 2007, Pages 551-557

Involvement of α-receptors and potassium channels in the mechanism of action of sildenafil citrate

Author keywords

receptors; Corpus cavernosum; Erectile dysfunction; Phosphodiesterase 5 inhibitors; Potassium channels; Sildenafil citrate

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; DIAZOXIDE; N(G) NITROARGININE; PHENTOLAMINE; PHENYLEPHRINE; PHOSPHODIESTERASE V INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PRAZOSIN; SILDENAFIL; TETRYLAMMONIUM;

EID: 35848957503     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901590     Document Type: Article
Times cited : (12)

References (30)
  • 1
    • 29244475738 scopus 로고    scopus 로고
    • Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum
    • Hashitani H, Yanai Y, Shirasawa N, Soji T, Tomita A, Kohri K et al. Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum. J Physiol 2005; 569(Part 3): 723-735.
    • (2005) J Physiol , vol.569 , Issue.PART 3 , pp. 723-735
    • Hashitani, H.1    Yanai, Y.2    Shirasawa, N.3    Soji, T.4    Tomita, A.5    Kohri, K.6
  • 2
    • 0034020272 scopus 로고    scopus 로고
    • Role of alpha adrenergic receptors in erectile function
    • Traish A, Kim NN, Moreland RB, Goldstein I. Role of alpha adrenergic receptors in erectile function. Int J Impot Res 2000; 12(Suppl 1): S48-S63.
    • (2000) Int J Impot Res , vol.12 , Issue.SUPPL. 1
    • Traish, A.1    Kim, N.N.2    Moreland, R.B.3    Goldstein, I.4
  • 3
    • 0032744321 scopus 로고    scopus 로고
    • adrenergic receptors in the penis: Identification, characterization, and physiological function
    • Traish AM, Kim NN, Godstein I, Moreland RB. adrenergic receptors in the penis: identification, characterization, and physiological function. J Androl 1999; 20: 671-682.
    • (1999) J Androl , vol.20 , pp. 671-682
    • Traish, A.M.1    Kim, N.N.2    Godstein, I.3    Moreland, R.B.4
  • 4
    • 4644244821 scopus 로고    scopus 로고
    • Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders
    • Gopalakrishnan M, Shieh CC. Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders. Expert Opin Ther Targets 2004; 8: 437-458.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 437-458
    • Gopalakrishnan, M.1    Shieh, C.C.2
  • 5
    • 35848960717 scopus 로고    scopus 로고
    • Role of ionic channels in the regulation of cavernous smooth muscle tone
    • Xing J, Cui X, Qiu S. Role of ionic channels in the regulation of cavernous smooth muscle tone. Zhonghua Nan Ke Xue 2004; 10: 941-943.
    • (2004) Zhonghua Nan Ke Xue , vol.10 , pp. 941-943
    • Xing, J.1    Cui, X.2    Qiu, S.3
  • 6
    • 23844554901 scopus 로고    scopus 로고
    • Past, present and future: A 7 year update of Viagra (sildenafil citrate)
    • Jackson G, Gillies H, Osterloh I. Past, present and future: a 7 year update of Viagra (sildenafil citrate). Int J Clin Pract 2005; 59: 680-691.
    • (2005) Int J Clin Pract , vol.59 , pp. 680-691
    • Jackson, G.1    Gillies, H.2    Osterloh, I.3
  • 7
    • 33644781490 scopus 로고    scopus 로고
    • Compliance of sildenafil treatment for erectile dysfunction and factors affecting it
    • Jiann BP, Yu CC, Su CC, Tsai JY. Compliance of sildenafil treatment for erectile dysfunction and factors affecting it. Int J Impot Res 2006; 18: 146-149.
    • (2006) Int J Impot Res , vol.18 , pp. 146-149
    • Jiann, B.P.1    Yu, C.C.2    Su, C.C.3    Tsai, J.Y.4
  • 8
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum on response to nonadrenergic noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum on response to nonadrenergic noncholinergic neurotransmission. N Engl J Med 1992; 326: 90-94.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 9
    • 0032965830 scopus 로고    scopus 로고
    • Sildenafil: A review of its use in erectile dysfunction
    • Langtry HD, Markham A. Sildenafil: a review of its use in erectile dysfunction. Drugs 1999; 57: 967-989.
    • (1999) Drugs , vol.57 , pp. 967-989
    • Langtry, H.D.1    Markham, A.2
  • 10
    • 0032445219 scopus 로고    scopus 로고
    • Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
    • Ballard SA, Gingell JC, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urology 1998; 159: 2164-2171.
    • (1998) J Urology , vol.159 , pp. 2164-2171
    • Ballard, S.A.1    Gingell, J.C.2    Tang, K.3    Turner, L.A.4    Price, M.E.5    Naylor, A.M.6
  • 11
    • 0028034304 scopus 로고
    • Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms
    • Sparwasser C, Drescher P, Will JA, Madsen PO. Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms. J Urol 1994; 152(Part 1): 2159-2163.
    • (1994) J Urol , vol.152 , Issue.PART 1 , pp. 2159-2163
    • Sparwasser, C.1    Drescher, P.2    Will, J.A.3    Madsen, P.O.4
  • 12
    • 1842866302 scopus 로고    scopus 로고
    • Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum
    • Sharabi FM, Daabees TT, El-Metwally MA, Senbel AM. Comparative effects of sildenafil, phentolamine, yohimbine and L-arginine on the rabbit corpus cavernosum. Fundam Clin Pharmacol 2004; 18: 187-194.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 187-194
    • Sharabi, F.M.1    Daabees, T.T.2    El-Metwally, M.A.3    Senbel, A.M.4
  • 13
    • 0015373239 scopus 로고
    • The rat anococcygeus muscle and its response to nerve stimulation and to some drugs
    • Gillespie JS. The rat anococcygeus muscle and its response to nerve stimulation and to some drugs. Br J Pharmacol 1972; 45: 404-416.
    • (1972) Br J Pharmacol , vol.45 , pp. 404-416
    • Gillespie, J.S.1
  • 14
    • 0026438790 scopus 로고
    • Heterogeneous distribution of endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rats
    • H 1090-H 1094
    • Nagao T, Illiano S, Vanhoutte P. Heterogeneous distribution of endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rats. Am J Physiology 1992; 263(Part 2): H 1090-H 1094.
    • (1992) Am J Physiology , vol.263 , Issue.PART 2
    • Nagao, T.1    Illiano, S.2    Vanhoutte, P.3
  • 15
    • 0028284920 scopus 로고
    • Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta
    • Fahim M, EL-Mas MM, Abdel Rahman AA, Mostafa SJ. Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta. Eur J Pharmacol 1994; 254: 183-191.
    • (1994) Eur J Pharmacol , vol.254 , pp. 183-191
    • Fahim, M.1    EL-Mas, M.M.2    Abdel Rahman, A.A.3    Mostafa, S.J.4
  • 16
    • 0023635190 scopus 로고
    • Effects of some calcium channel blockers on isolated human penile erectile tissues
    • Fovaeus M, Andersson KE, Hedlund H. Effects of some calcium channel blockers on isolated human penile erectile tissues. J Urol 1984; 138: 1267-1272.
    • (1984) J Urol , vol.138 , pp. 1267-1272
    • Fovaeus, M.1    Andersson, K.E.2    Hedlund, H.3
  • 17
    • 0027158882 scopus 로고
    • Characterization of calcium channel blocker induced smooth muscle relaxation using a model of isolated corpus cavernosum
    • Kerfoot WW, Park HY, Schwartz LB, Hagen P, Carson CC. Characterization of calcium channel blocker induced smooth muscle relaxation using a model of isolated corpus cavernosum. J Urol 1993; 150: 249-252.
    • (1993) J Urol , vol.150 , pp. 249-252
    • Kerfoot, W.W.1    Park, H.Y.2    Schwartz, L.B.3    Hagen, P.4    Carson, C.C.5
  • 18
  • 19
    • 0037973578 scopus 로고    scopus 로고
    • Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum
    • Palea S, Barras M. Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum. BJU Int 2003; 91: 873-877.
    • (2003) BJU Int , vol.91 , pp. 873-877
    • Palea, S.1    Barras, M.2
  • 20
    • 0028199896 scopus 로고
    • Noradrenergic-nitrergic interactions in the rat anococcygeus muscle: Evidence for postjunctional modulation by nitric oxide
    • Kasakov L, Belai A, Vlaskovska M, Burnstock G. Noradrenergic-nitrergic interactions in the rat anococcygeus muscle: evidence for postjunctional modulation by nitric oxide. Br J Pharmacol 1994; 112: 403-410.
    • (1994) Br J Pharmacol , vol.112 , pp. 403-410
    • Kasakov, L.1    Belai, A.2    Vlaskovska, M.3    Burnstock, G.4
  • 21
    • 0020672185 scopus 로고
    • Interaction of verapamil and other calcium channel blockers with α1- and α2-adrenergic receptors
    • Motulsky HJ, Snavely MD, Haughes RJ, Insel PA. Interaction of verapamil and other calcium channel blockers with α1- and α2-adrenergic receptors. Circ Res 1983; 52: 226-229.
    • (1983) Circ Res , vol.52 , pp. 226-229
    • Motulsky, H.J.1    Snavely, M.D.2    Haughes, R.J.3    Insel, P.A.4
  • 22
    • 0022598456 scopus 로고
    • Pharmacodynamic profiles of different calcium channel blockers
    • Andersson KE. Pharmacodynamic profiles of different calcium channel blockers. Acta Pharmacol Toxicol 1986; 58: 31-33.
    • (1986) Acta Pharmacol Toxicol , vol.58 , pp. 31-33
    • Andersson, K.E.1
  • 23
    • 0023859179 scopus 로고
    • The pharmacology of potassium channels and their therapeutic potential
    • Cook NS. The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol Sci 1988; 9: 21-31.
    • (1988) Trends Pharmacol Sci , vol.9 , pp. 21-31
    • Cook, N.S.1
  • 24
    • 0036725094 scopus 로고    scopus 로고
    • K channels as molecular targets for the treatment of erectile dysfunction
    • Christ GJ. K channels as molecular targets for the treatment of erectile dysfunction. J Androl 2002; 23: S10-S19.
    • (2002) J Androl , vol.23
    • Christ, G.J.1
  • 25
    • 0025363006 scopus 로고
    • K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit
    • Holmquist F, Andersson KE, Fovaeus M, Hedlund H. K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit. J Urol 1990; 144: 146-151.
    • (1990) J Urol , vol.144 , pp. 146-151
    • Holmquist, F.1    Andersson, K.E.2    Fovaeus, M.3    Hedlund, H.4
  • 26
    • 0042324046 scopus 로고    scopus 로고
    • Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells
    • Insuk SO, Chae MR, Choi JW, Yang DK, Sim JH, Lee SW. Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells. Int J Impot Res 2003; 15: 258-266.
    • (2003) Int J Impot Res , vol.15 , pp. 258-266
    • Insuk, S.O.1    Chae, M.R.2    Choi, J.W.3    Yang, D.K.4    Sim, J.H.5    Lee, S.W.6
  • 27
    • 0033739716 scopus 로고    scopus 로고
    • Sulphonylurea- sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro
    • Almond SC, Paterson DJ. Sulphonylurea- sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro. J Mol Cell Cardiol 2000; 32: 2065-2073.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 2065-2073
    • Almond, S.C.1    Paterson, D.J.2
  • 29
    • 32044455985 scopus 로고    scopus 로고
    • Ca2+-activated K+ (KCa) channels are involved in the relaxations elicited by sildenafil in penile resistance arteries
    • Prieto D, Rivera L, Benedito S, Recio P, Villalba N, Hernandez M et al. Ca2+-activated K+ (KCa) channels are involved in the relaxations elicited by sildenafil in penile resistance arteries. Eur J Pharmacol 2006; 531: 232-237.
    • (2006) Eur J Pharmacol , vol.531 , pp. 232-237
    • Prieto, D.1    Rivera, L.2    Benedito, S.3    Recio, P.4    Villalba, N.5    Hernandez, M.6
  • 30
    • 13844256288 scopus 로고    scopus 로고
    • Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: A human in vivo study
    • Gori T, Sicuro S, Dragoni S, Donati G, Forconi S, Parker JD. Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation 2005; 111: 742-746.
    • (2005) Circulation , vol.111 , pp. 742-746
    • Gori, T.1    Sicuro, S.2    Dragoni, S.3    Donati, G.4    Forconi, S.5    Parker, J.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.