Phenylalanine-24 in the N-terminal region of ammodytoxins is important for both enzymic activity and presynaptic toxicity

Biochemical Journal

Volumn 363, Issue 2, 2002, Pages 353-358

  Petan, Toni ^a   Križaj, Igor ^a   Gubenšek, Franc ^a   Pungerčar, Jože ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Calmodulin; Phospholipase A2; Receptor binding affinity; Site directed mutagenesis; Vipera ammodytes ammodytes

Indexed keywords

AROMATIC COMPOUNDS; BACTERIA; CATALYSIS; ENZYMES; TOXICITY;

MUTANTS;

BIOCHEMISTRY;

AMMODYTOXIN A; CALMODULIN; PHENYLALANINE; PHOSPHOLIPASE;

ACETYLCHOLINE RELEASE; ACUTE TOXICITY; ADSORPTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENDOCYTOSIS; ENZYME SUBSTRATE; MEDIATOR RELEASE; NEUROTOXICITY; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CALMODULIN; KINETICS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEUROTOXINS; PHOSPHOLIPASES A; PRESYNAPTIC TERMINALS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SWINE; VIPER VENOMS;

AMMODYTES; ANIMALIA; BACTERIA (MICROORGANISMS); SERPENTES; VIPERA; VIPERA AMMODYTES; VIPERA AMMODYTES AMMODYTES;

EID: 0037090430     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3630353     Document Type: Article

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