Synthesis and evaluation of novel heterocyclic MMP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 24, 2007, Pages 6864-6870

  Hayashi, Ryuji ^a   Jin, Xiaomin ^a   Cook, Gregory R ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

bis Heterocycles; Matrix metalloproteinase inhibitors; Pyridinones

Indexed keywords

GELATINASE A; GELATINASE B; HETEROCYCLIC COMPOUND; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE INHIBITOR; PYRIDONE DERIVATIVE; TETRAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; REACTION ANALYSIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

CATALYTIC DOMAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; MATRIX METALLOPROTEINASES; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 35848954959     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.020     Document Type: Article

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