Hypoglutamatergic activity in the STOP knockout mouse: A potential model for chronic untreated schizophrenia

Journal of Neuroscience Research

Volumn 85, Issue 15, 2007, Pages 3487-3493

  Brenner, Eiliv ^a   Sonnewald, Ursula ^a   Schweitzer, Annie ^b   Andrieux, Annie ^b   Nehlig, Astrid ^c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b CEA GRENOBLE   (France)

^c INSERM   (France)

Author keywords

Astrocytes; Glutamate; Glutamine; Neurons; Schizophrenia; STOP KO mice

Indexed keywords

ACETIC ACID; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVATE CARBOXYLASE; SUCCINIC ACID; TAURINE;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY METABOLISM; FOREBRAIN; GENOTYPE; GLIA CELL; HETEROZYGOSITY; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; MESENCEPHALON; MOUSE; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA;

ANIMALS; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOPAMINE; ENERGY METABOLISM; GLUTAMIC ACID; GLUTAMINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; SCHIZOPHRENIA; SYNAPTIC VESICLES;

EID: 35848950740     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21200     Document Type: Conference Paper

References (41)

1. Andrieux A, Salin PA, Vernet M, et al. 2002. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. Genes Dev 16:2350-2364.
2. Bartha R, al-Semaan YM, Williamson PC, et al. 1999. A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients. Biol Psychiatry 45:1403-1411.
3. Baslow MH. 2003. Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation. J Mol Neurosci 21:185-90.
4. Berl S, Clarke DD. 1983. The metabolic compartmentation concept. In: Hertz L, Kvamme E, McGeer EG, Schousboe A, editors. Glutamine, glutamate and GABA in the central nervous system. New York: Alan R. Liss. p 205-217.
5. Brenner E, Kondziella D, Haberg A, Sonnewald U. 2005. Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801. J Neurochem 94:1594-1603.
6. Brun P, Bégou M, Andrieux A, et al. 2005. Dopaminergic transmission in STOP null mice. J Neurochem 94:63-73.
7. Carlsson A, Waters N, Holm-Waters S, et al. 2001. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu Rev Pharmacol Toxicol 41:237-260.
8. Carlsson M, Carlsson A, Nilsson M. 2004. Schizophrenia: from dopamine to glutamate and back. Curr Med Chem 11:267-277.
9. Deutsch SI, Rosse RB, Schwartz BL, Mastropaolo J. 2001. A revised excitotoxic hypothesis of schizophrenia: therapeutic implications. Clin Neuropharmacol 24:43-49.
10. Eyjolfsson EM, Brenner E, Kondziella D, Sonnewald U. 2006. Repeated injection of MK801: an animal model of schizophrenia? Neurochem Int 48:541-546.
11. Friston KJ. 2002. Dysfunctional connectivity in schizophrenia. World Psychiat 1:66-71.
12. Galiano MR, Bosc C, Schweitzer A, et al. 2004. Astrocytes and oligodendrocytes express different STOP protein isoforms. J Neurosci Res 78:329-337.
13. Geddes JW, Wood JD. 1984. Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid. J Neurochem 42:16-24.
14. Halberstadt A. 1995. The phencyclidine-glutamate model of schizophrenia. Clin Neuropharmacol 18:237-249.
15. Harrison PJ. 1999. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122:593-624.
16. Kegeles LS, Abi-Dargham A, Zea-Ponce Y, et al. 2000. Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry 48:627-640.
17. Kondziella D, Brenner E, Eyjolfsson EM, et al. 2005. Glial-neuronal interactions are impaired in the schizophrenia model of repeated MK801 exposure. Neuropsychopharmacology [E-pub].
18. Kosenko E, Llansola M, Montoliu C, et al. 2003. Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int 43:493-499.
19. Lahti AC, Koffel B, LaPorte D, Tamminga CA. 1995. Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neuropsychopharmacology 13:9-19.
20. 13C nuclear magnetic resonance spectroscopy. Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 22:1523-1531.
21. Marenco S, Weinberger DR. 2000. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 12:501-527.
22. Melo TM, Nehlig A, Sonnewald U. 2006. Neuronal-glial interactions in rats fed a ketogenic diet. Neurochem Int 48:498-507.
23. Miller DW, Abercrombie ED. 1996. Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain Res Bull 40:57-62.
24. Mirnics K, Middleton FA, Lewis DA, Levitt P. 2001. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24:479-486.
25. Murphy DD, Cole NB, Greenberger V, Segal M. 1998. Estradiol increases dendritic spine density by reducing GABA neurotransmission in hippocampal neurons. J Neurosci 18:2550-2559.
26. Norenberg MD, Martinez-Hernandez A. 1979. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161:303-310.
27. Olney JW, Farber NB. 1995. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52:998-1007.
28. Ottersen OP, Storm-Mathisen J. 1986. Excitatory amino acid pathways in the brain. Adv Exp Med Biol 203:263-284.
29. Palaiologos G, Schousboe A, Hertz L. 1988. Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate. J Neurochem 51:317-20.
30. 13C MR spectroscopy study of lactate as substrate for rat brain. Dev Neurosci 22:429-436.
31. Seeman P. 1987. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1:133-152.
32. Shank RP, Bennett GS, Freytag SO, Campbell GL 1985. Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acids neurotransmitter pool. Brain Res 329:362-367.
33. Shulman RG, Rothman DL, Behar KL, Hyder F. 2004. Energetic basis of brain activity: implications fro brain neuroimaging. Trends Neurosci 27:489-495.
34. 13C]glucose infusion. J Neurochem 76:975-989.
35. 13C NMR spectroscopy. NMR Biomed 16:424-429.
36. 13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons. Neurochem Int 22:19-29.
37. 13C-NMR studies. J Neurochem 67:1711-1717.
38. Taylor A, McLean M, Morria P, Bachelard H. 1996. Approaches to studies on neuronal/glial relationships by 13C-MRS analysis. Dev Neurosci 18:434-442.
39. Theberge J, Bartha R, Drost DJ, et al. 2002. Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatry 159:1944-1946.
40. Theberge J, Al-Semaan Y, Williamson PC, et al. 2003. Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry 160:2231-2233.
41. Waniewski RA, Martin DL. 1998. Preferential utilization of acetate by astrocytes is attributable to transport. J Neurosci 18:5225-5233.