13C MR spectroscopy study of lactate as substrate for rat brain

Developmental Neuroscience

Volumn 22, Issue 5-6, 2000, Pages 429-436

  Qu, Hong ^a,b   Håberg, Asta ^a   Haraldseth, Olav ^a   Unsgård, Geirmund ^a   Sonnewald, Ursula ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b SINTEF   (Norway)

Author keywords

Astrocytes; Glucose; Lactate; MR spectroscopy; Neurons

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYL COENZYME A; ALANINE; AMINO ACID; ASPARTIC ACID; CARBON 13; GLUCOSE; GLUTAMIC ACID; LACTIC ACID; NEUROTRANSMITTER; PYRUVATE CARBOXYLASE; PYRUVIC ACID; TRICARBOXYLIC ACID; UREA; CARBON; GLUTAMINE; TAURINE; TISSUE EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; DECAPITATION; GLUCONEOGENESIS; GLUCOSE INTAKE; GLUCOSE METABOLISM; LACTATE BLOOD LEVEL; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROSCOPY; WAKEFULNESS; ANIMAL; BIOSYNTHESIS; BRAIN; BRAIN LEVEL; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; WISTAR RAT;

ACETYL COENZYME A; ALANINE; ANIMALS; ASPARTIC ACID; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; CARBON ISOTOPES; GAMMA-AMINOBUTYRIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; INJECTIONS, INTRAVENOUS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEURONS; PYRUVATE CARBOXYLASE; RATS; RATS, WISTAR; TAURINE; TISSUE EXTRACTS;

EID: 0033625878     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017472     Document Type: Article

References (46)

1. 13C-NMR spectroscopy
2. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
3. Protection of ischaemic synaptosomes from calcium overload by addition of exogenous lactate
4. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
5. Ketone bodies and brain glutamate and GABA metabolism
6. Stimulate release of lactate in freely moving rats is dependent on the uptake of glutamate
7. Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain
8. Glycogen in astrocytes: Possible function as lactate supply for neighbouring cells
9. Energy metabolism in developing brain cells
10. Expression of the monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
11. Expression of the monocarboxylate transporters MCT2 by rat brain glia
12. Cerebral extracellular glucose and lactate concentration during and after moderate hypoxia in glucose- and saline-infused rats
13. Glial formation of pyruvate and lactate from TCA cycle intermediates: Implications for the inactivation of transmitter amino acids
14. 13C NMR spectroscopy study
15. Cerebral blood flow and metabolism during hypoglycemia in newborn dogs
16. 13C nuclear magnetic resonance spectroscopy: A novel approach to the study of middle cerebral artery occlusion in the rat
17. Lactate metabolism and its effects on glucose metabolism in an excised neural tissue
18. 13C NMR spectroscopy
19. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
20. Energy on demand
21. Glucose transporter proteins in the brain
22. Protection by lactate of cerebral function during hypoglycaemia
23. Dynamic changes in glucose metabolism by lactate loading as revealed by a positron autoradiography technique using rat living brain slices
24. Lactate uptake and metabolism by brain during hyperlactemia and hypoglycemia
25. Stereospecific permeability of rat blood-brain barrier to lactic acid
26. Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
27. Precursors in vivo of glutamate, aspartate and their derivatives of rat brain
28. 2-fixing enzymes in the metabolism of rat brain
29. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
30. Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs adult brain
31. High extracellular potassium concentrations stimulate oxidative metabolism in a glutamatergic neuronal culture and glycolysis in cultured astrocytes but have no stimulatory effect in a GABAergic neuronal culture
32. Developmental expression and molecular cloning of REMP, a novel retinal epithelial membrane protein
33. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina
34. Trafficking between glia and neurons of TCA cycle intermediates and related metabolites
35. Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: Further in vitro validation
36. Lactate-supported synaptic function in the rat hippocampal slice preparation
37. Pyruvate carboxylase: An astrocytic-specific enzyme implicated in the replenishment of amino acids neurotransmitter pools
38. Circulation and energy metabolism of the brain
39. MRS study of glutamate metabolism in cultured neurons/glia
40. Metabolic coupling between glia and neurons
41. A model of compartmentation in mouse brain based on glucose and acetate metabolism
42. 13C nuclear magnetic resonance spectroscopy
43. 13C-NMR spectroscopy
44. Lactate release from cultured astrocytes and neurons: A comparison
45. Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium
46. Pyruvate carboxylase activity in primary cultures of astrocytes and neurons