Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5

Neuropharmacology

Volumn 34, Issue 8, 1995, Pages 871-886

  Daggett, L P ^a   Sacaan, A I ^a   Akong, M ^a   Rao, S P ^a   Hess, S D ^a   Liaw, C ^a   Urrutia, A ^a   Jachec, C ^a   Ellis, S B ^a   Dreessen, J ^b   Knopfel T ^b   Landwehrmeyer, G B ^c   Testa, C M ^c   Young, A B ^c   Varney, M ^a   Johnson, E C ^a   Velicelebi G ^a  

^a SIBIA Corp   (United States)

^b CIBA GEIGY LTD   (Switzerland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

binding; cloning; expression (functional); expression (stable); expression (transient); immunoblot analysis; in situ hybridization; InsP formation; intracellular calcium; Metabotropic glutamate receptors (human); splice variants

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; ALPHA METHYLCARBOXYPHENYLGLYCINE; CALCIUM; COMPLEMENTARY DNA; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; INOSITOL PHOSPHATE; MESSENGER RNA; METABOTROPIC RECEPTOR; QUISQUALIC ACID; RADIOISOTOPE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADULT; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG INHIBITION; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RECOMBINANT DNA TECHNOLOGY; SPECIES DIFFERENCE; XENOPUS;

ANIMAL; BASE SEQUENCE; CALCIUM; DNA, COMPLEMENTARY; ELECTROPHYSIOLOGY; FIBROBLASTS; GLUTAMIC ACID; HUMAN; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; INOSINE TRIPHOSPHATE; MICE; MOLECULAR SEQUENCE DATA; OOCYTES; PRECIPITIN TESTS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; TRANSFECTION; XENOPUS LAEVIS;

EID: 0029144222     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00085-K     Document Type: Article

References (40)

1. 2+ signal transduction
2. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells
3. Calcium phosphate transfections
4. Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high-and low-affinity agonist states
5. Lithium amplifies agonist dependent phosphatidylinositol responses in brain and salivary glands
6. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
7. Coupling of D2 and D3 dopamine receptors to G-proteins
8. Immunological detection of the NMDAR1 glutamate receptor subunit expressed in human embryonic kidney 293 cells and in rat brain
9. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
10. 2 subunits of a DHP-sensitive calcium channel
11. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.
12. 2+ indicators with greatly improved fluorescence properties
13. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes
14. Cloned glutamate receptors
15. Cloning, expression, and gene structure of a G-protein-coupled glutamate receptor from rat brain
16. Optimization of PCRs
17. Sequence and expression of a metabotropic glutamate receptor
18. Pharmacological and biochemical characterization of complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein
19. A variant of metabotropic glutamate receptor subtype 5: An evolutionarily conserved insertion with no termination codon
20. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5
21. The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system
22. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for l-2-amino-4-phosphonobutyrate
23. Molecular diversity of glutamate receptors and implications for brain function
24. Metabotropic Glutamate Receptors: Synaptic transmission, modulation, and plasticity
25. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction
26. Hydrodynamic characterization of vasoactive intestinal peptide receptors extracted from rat lung membranes in Triton X-100 and n-Octyl-β-d-glucopyranoside
27. A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover
28. Domains involved in the specificity of G-protein activation in phospholipase C-coupled metabotropic glutamate receptors
29. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes
30. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
31. Cloning and expression of a new member of the d-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors
32. 3H] glutamate receptor binding in membranes
33. Comparison of the (1S,3R)-1-aminocyclopentate-1,3-dicarboxylic acid (1S,3R-ACPD)-and 1R,3S-ACPD-stimulated brain phosphoinositol hydrolysis
34. Functional characterization of metabotropic glutamate subtypes
35. A family of metabotropic glutamate receptors
36. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors
37. Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
38. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
39. Cellular and subcellular localization of the mGluR5a metabotropic glutamate receptor in rat spinal cord