Chemical synthesis of six novel 17β-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5372-5381

  Chen, Aaron Yun ^a   Lee, Anthony J ^a,b   Jiang, Xiang Rong ^a   Bao, Ting Zhu ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; ESTRADIOL; ESTROGEN; ESTRONE DERIVATIVE; ISOPROTEIN; OXYGEN DERIVATIVE; PHENOL DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CATALYSIS; CHEMICAL BINDING; CONTROLLED STUDY; DRUG STRUCTURE; ESTROGEN ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE METABOLISM; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LIVER MICROSOME; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION; ESTRADIOL; ESTROGENS; ESTRONE; HUMANS; ISOENZYMES; MICROSOMES, LIVER; RECOMBINANT PROTEINS;

EID: 35848940750     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0707323     Document Type: Article

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