NADPH-dependent metabolism of estrone by human liver microsomes

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 838-849

  Lee, Anthony J ^a,b,c   Mills, Laura H ^a,b,c   Kosh, Joseph W ^a,b,c   Conney, Allan H ^a,b,c   Ting Zhu, B A O ^a,b,c  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b College of Pharmacy ^*  (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA HYDROXYESTRONE; 16BETA HYDROXYESTRONE; 6 BETA HYDROXYESTRONE; CATECHOL ESTROGEN; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; ESTRADIOL; ESTRONE; ESTRONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENZYME ACTIVITY; ESTROGEN METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE METABOLISM; HORMONE STRUCTURE; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SEX DIFFERENCE; STRUCTURE ANALYSIS;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ESTRONE; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NADP; REPRODUCIBILITY OF RESULTS; SEX CHARACTERISTICS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEROID 16-ALPHA-HYDROXYLASE;

EID: 0036182258     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.838     Document Type: Article

References (51)

1. Isolation and identification of bile estrogens in pregnant women
2. Gas chromatographic and mass spectrometric studies on oestrogens in bile: Part I. Pregnant women
3. Age- and sex-related expression of cytochromes P450f and P450g in rat liver
4. Oestradiol 16α-hydroxylase: A risk marker for breast cancer
5. Metabolism of oestrone and oestradiol-17β in human liver in vitro
6. 16β-hydroxyoestrone, a metabolite of oestradiol in man
7. 17β-estradiol metabolism by selectively-expressed human cytochromes P450
8. Estrogens as endogenous genotoxic agents - DNA adducts and mutations
9. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes memorial lecture
10. 17β-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P450: Roles of individual forms, inductive effects, developmental patterns and alterations by gonadectomy and hormone replacement
11. Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway
12. 14
13. Aromatic hydroxylation of estrogens
14. Increased estrogen 16α-hydroxylase activity in women with breast and endometrial cancer
15. Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics
16. Cytochrome P-450 3A4: Regulation and role in drug metabolism
17. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
18. Differential expression of oncogenous c-fos, c-myc and neu/Her-2 induced by estradiol and 16α-hydroxyestrone in human cancer cell line
19. 16α-hydroxylation of estrone by human cytochrome P4503A4/5
20. Estrone sulfate, estrone and estradiol concentrations in normal and cirrhotic postmenopausal women
21. Serum 17β-estradiol and estrone levels in postmenopausal women with and without endometrial cancer
22. Nature of cytochromes P450 involved in the 2-/4-hydroxylation of estradiol in human liver microsomes
23. Creepage of estrogens vs. loss by sorption on glassware
24. Isolation of 16β-hydroxyoestrone from the urine of pregnant women
25. Characterization of the NADPH-dependent metabolism of 17β-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5
26. Is estradiol a genotoxic mutagenic carcinogen?
27. Interindividual variability in inhibition and induction of cytochrome P450 enzymes
28. Substrate inhibition kinetics for cytochrome P450-catalyzed reactions
29. Changes in serum estrogen levels in women during tamoxifen therapy
30. Purification, characterization and pituitary regulation of the sex-specific cytochrome P450 15β-hydroxylase from liver microsomes of untreated female rats
31. The isolation of 16-epioestriol from the urine of pregnant women
32. P450 enzymes of estrogen metabolism
33. Identification of 6α- and 7α-hydroxyestrone as major metabolites of estrone and estradiol in porcine uterus
34. 14 by mouse liver microsomes
35. Upregulation of estradiol C16α-hydroxylation in human breast tissue: A potential biomarker of breast cancer risk
36. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity
37. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
38. Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone
39. High-performance liquid chromatography separation of hydroxylated estradiol metabolites: Formation of estradiol metabolites by liver microsomes from male and female rats
40. Effects of phenobarbital, dexamethasone, and 3-methylcholanthrene administration on the metabolism of 17β-estradiol by liver microsomes from female rats
41. Covalent binding of the endogenous estrogen 16α-hydroxyestrone to estradiol receptor in human breast cancer cells: Characterization and intranuclear localization
42. In vitro and in vivo drug interactions involving human CYP 3A
43. Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes
44. Rat hepatic cytochrome P450 isozyme 2C: Identification as a male-specific developmentally induced steroid 16α-hydroxylase and comparison to a female-specific cytochrome P450 isoenzyme
45. Regulation of rat hepatic cytochrome P450: Age-dependent expression, hormonal imprinting and xenobiotic inducibility of sex-specific isozymes
46. Identification of a polymorphically expressed member of the human cytochrome P450 III family
47. The human hepatic cytochromes P450 involved in drug metabolism
48. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes
49. Functional role of estrogen metabolism in target cells: Review and perspectives
50. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
51. Dietary administration of an extract from rosemary leaves enhances the liver microsornal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice