Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids

Archives of Toxicology

Volumn 81, Issue 11, 2007, Pages 777-784

  Mitchell, Alyson E ^a   Burns, Stephanie A ^a   Rudolf, Jaime L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

(+) Catechin; Flavone; Flavonoids; Gender; GSTs; Morin; Naringenin; Quercetin

Indexed keywords

CATECHIN; FLAVONE; FLAVONOID; GLUTATHIONE TRANSFERASE; ISOENZYME; MORIN; NARINGENIN; QUERCETIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SWISS WEBSTER MOUSE;

ANIMALS; ANTIOXIDANTS; FEMALE; FLAVONOIDS; GLUTATHIONE TRANSFERASE; ISOENZYMES; LIVER; MALE; MICE; ORCHIECTOMY; ORGAN SIZE; SEX CHARACTERISTICS; TESTOSTERONE;

ANIMALIA; MUS;

EID: 35748985548     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0210-9     Document Type: Article

References (41)

1. Ansell PJ, Espinosa-Nicholas C, Curran EM, Judy BM, Philips BJ, Hannink M, Lubahn DB (2004) In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens. Endocrinology 145:311-317
2. Benson AM, Batzinger RP, Ou S-YL, Bueding E, Cha Y-N, Talalay P (1978) Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo[a]pyrene by dietary antioxidants. Cancer Res 38:4486-4495
3. Benson AM, Cha Y-N, Bueding E, Heine HS, Talalay P (1979) Elevation of extrahepatic glutathione S-transferases and epoxide hydratase activities by 2(3)- tert-butyl-4-hydroxyanisole. Cancer Res 39:2971-2977
4. Benson AM, Hunkeler MJ, York JL (1989) Mouse hepatic glutathione transferase isoenzymes and their differential induction by anticarcinogens. Specificities of butylated hydroxyanisole and bisethylxanthogen as inducers of glutathione transferases in male and female CD-1 mice. Biochem J 261:1023-1029
5. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
6. Burns SA, Hong YJ, Mitchell AE (2004) Direct liquid chromatography-mass spectrometry method for the detection of glutathione S-transferase isozymes and investigation of their expression in response to dietary flavone. J Chromatogr B Analyt Technol Biomed Life Sci 809:331-337
7. Chen C, Kong A-NT (2005) Dietary cancer-chemopreventative compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 6:318-326
8. Denison MS, Pandini A, Nagy SR, Baldwin EP, Bonati L (2002) Ligand binding and activation of the Ah receptor. Chem Biol Interact 141:3-24
9. Egaas E, Falls JG, Dauterman WC (1995) A study of gender, strain and age differences in mouse liver glutathione-S-transferase. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 110:35-40
10. Falkner KC, Pinaire JA, Xiao GH, Geoghegan TE, Prough RA, (2001) Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. Mol Pharmacol 60:611-619
11. Fiander H, Schneider H (2000) Dietary ortho phenols that induce glutathione S-transferase and increase the resistance of cells to hydrogen peroxide are potential cancer chemopreventives that act by two mechanisms: the alleviation of oxidative stress and the detoxification of mutagenic xenobiotics. Cancer Lett 156:117-124
12. Gandhi RK, Khanduja KL (1993) Impact of quercetin consumption on phase-i and phase- ii drug metabolizing enzymes in mice. J Clin Biochem Nutr 14:107-112
13. Gopal PV, Sriram AV, Sharma D, Singh R (2000) Glutathione-S-transferase in the ageing rat brain cerebrum and the effect of chlorpromazine. Gerontology 46:7-11
14. Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
15. Hatayama I, Satoh K, Sato K (1986) Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice. Biochem Biophys Res Commun 140:581-588
16. Hayes JD, Flanagan JU, Jowsey IR (2005) Glutathione transferases. Annu Rev Pharmacol Toxicol 45:51-88
17. Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600
18. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342:1007-1011
19. Igarashi T, Satoh T (1989) Sex and species differences in glutathione S-transferase activities. Drug Metabol Drug Interact 7:191-212
20. Kang KW, Park EY, Kim SG (2003) Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis 24:475-482
21. Kawabata K, Tanaka T, Honjo S, Kakumoto M, Hara A, Makita H, Tatematsu N, Ushida J, Tsuda H, Mori H (2001) Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis. Int J Cancer 94:910
22. Kensler TW, Groopman JD, Sutter TR, Curphey TJ, Roebuck B (1999) Development of cancer chemopreventive agents: Oltipraz as a paradigm. Chem Res Toxicol 12:113-126
23. Lamartiniere CA (1981) The hypothalamic-hypophyseal-gonadal regulation of hepatic glutathione S-transferases in the rat. Biochem J 198:211-217
24. Masella R, Benedetto R, Vari R, Filesi C, Giovannini C (2005) Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J Nutrtional Biochem 16:577-586
25. Million RR, Cassisi NJ, Clark JR (1989) Cancer of the head and neck. In: Devita VT, Hellman S, Rosenberg SA (eds) Cancer principles and practices in oncology. J. B. Lippincott, Philadelphia
26. Mitchell AE, Morin D, Lakritz J, Jones AD (1997) Quantitative profiling of tissue- and gender-related expression of glutathione S-transferase isoenzymes in the mouse. Biochem J 325:207-216
27. Moi P, Chan K, Asunis I, Cao A, Kan YW (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 91:9926-9930
28. Moon YJ, Xiadong W, Morris M (2006) Dietary flavonoids: effects on xenobiotic and carcinogenic metabolism. Toxicol In Vitro 20:187-210
29. Munday R, Munday CM (2004) Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem 52:1867-1871
30. Musonda CA, Helsby N, Chipman JK (1997) Effects of quercetin on drug metabolizing enzymes and oxidation of 2′,7-dichlorofluorescein in hepg2 cells. Human Exp Toxicol 16:700-708
31. Nijhoff WA, Bosboom MA, Smidt MH, Peters WH (1995) Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. Carcinogenesis 16:607-612
32. Nijhoff WA, Peters WH (1992) Induction of rat hepatic and intestinal glutathione S-transferases by dietary butylated hydroxyanisole. Biochem Pharmacol 4:596-600
33. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169
34. Scalbert A, Manach C, Morand C, Remesy C, Jimenez L (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45:287-306
35. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M (2006) (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 103:1024-1029
36. Siess M-H, Mas J-P, Canivenc-Lavier M-C, Suschetet M (1996) Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. J Toxicol Environ Health 49:481-496
37. Singhal SS, Saxena M, Awasthi S, Ahmad H, Sharma R, Awasthi YC (1992) Gender related differences in the expression and characteristics of glutathione S- transferases of human colon. Biochim Biophys Acta 1171:19-26
38. Srivastava PK, Waxman DJ (1993) Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver. Biochem J 294:159-165
39. Staffas L, Ellis EM, Hayes JD, Lundgren B, Depierre JW, Mankowitz L (1998) Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver. Biochem J 332:763-768
40. Steinmetz KA, Potter JD (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96:1027-1039
41. Williamson G, Plumb GW, Uda Y, Price KR, Rhodes MJC (1996) Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells. Carcinogenesis 17:2385-2387