Dietary quercetin glycosides: Antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells

Carcinogenesis

Volumn 17, Issue 11, 1996, Pages 2385-2387

  Williamson, Gary ^a   Plumb, Geoff W ^a   Uda, Yasushi ^b   Price, Keith R ^a   Rhodes, Michael J C ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b UTSUNOMIYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; GLYCOSIDE; IRON; ISOQUERCITRIN; MARKER; QUERCETIN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTOSIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; DIETARY INTAKE; DRUG ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER MICROSOME; MOUSE; NONHUMAN; ONION; PRIORITY JOURNAL;

EID: 0029832833     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.11.2385     Document Type: Article

References (19)

1. Knekt, P., Jarvinen, R., Reunanen, A. and Maatela, J. (1996) Flavonoid intake and coronary mortality in Finland: A cohort study. Br. Med. J., 312, 478-481.
2. Hertog, M.G.L., Hollman, P.C.H., Katan, M.B. and Kromhout, D. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands. Nutr. Cancer, 20, 21-29.
3. Dorant, E., van der Brandt, P.A., Goldbohm, R.A. and Sturmans, F. (1996) Consumption of onions and a reduced risk of stomach carcinoma. Gastroenterology, 110, 12-20.
4. Formica, J.V. and Regelson, W. (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol., 33, 1061-1080.
5. Cook, N.C. and Samman, S. (1996) Flavonoids - Chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem., 7, 66-76.
6. Price, K.R. and Rhodes, M.J.C. (1996) Analyses of the major flavonol glycosides present in varieties of onion (Allium cepa) and changes in composition resulting from autolysis. J. Sci. Food Agric., in press.
7. Park, Y.K. and Lee, C.Y. (1996) Identification of isorhamnetin 4′-glucoside in onions. J. Agr. Food Chem., 44, 34-36.
8. Hollman, P.C.H., de Vries, J.H.M., van Leeuwen, S.D., Mengelers, M.J.B. and Katan, M.B. (1995) Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am. J. Clin Nutr., 62, 1276-1282.
9. Prochaska, H.J. and Santamaria, A.B. (1988) Direct measurement of NAD(P)H; Quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzymes inducers. Anal. Biochem., 169, 328-336.
10. Salah, N., Miller, N.J., Paganga, G., Tijburg L., Bolwell, G.P. and Rice-Evans, C. (1995) Polyphenolic flavonols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch. Biochem. Biophys., 322, 339-346.
11. Plumb, G.W., Lambert, N.L., Chambers, S.J., Wanigatunga, S., Heaney, R.K., Plumb, J.A., Aruoma, O., Halliwell, B. and Williamson, G. (1996) Are extracts and purified glucosinolates from cruciferous vegetables antioxidants? Free Radical Res., 25, 75-86.
12. Tawfiq, N., Heaney, R.K., Plumb, J.A., Fenwick, G.R., Musk, S.R.R. and Williamson, G. (1995) Dietary glucosinolate as blocking agents against carcinogenesis: correlation between glucosinolate structure and induction of quinone reductase in murine hepa1c1c7 cells. Carcinogenesis, 16, 1191-1194.
13. Smith, P.K., Krohm, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J. and Klenk, D.C. (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem., 150, 76-85.
14. De Long, M.J., Prochaska, H.J. and Talalay, P. (1986) Induction of NAD(P)H:quinone oxidoreductase in murine hepatoma cells by phenolic antioxidants, azo dyes, and other chemoprotectants: A model system for the study of anticarcinogens. Proc. Natl Acad. Sci. USA, 83, 787-791.
15. Foti, M., Piattelli, M., Baratta, M.T. and Ruberto, G. (1996) Flavonoids, coumarins and cinnamic acids as antioxidants in a micellar system. Structure-activity relationship. J. Agric. Food Chem., 44, 497-501.
16. Rice-Evans, C.A., Miller, N.J., Bolwell, P.G., Bramley, P.M. and Pridham, J.B. (1995) The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radical. Res., 22, 375-383.
17. Cotelle, N., Bernier, J.-L., Catteau, J.-P., Pommery, J., Wallet, J.-C. and Gaydou, E.M. (1996) Antioxidant properties of hydroxy-flavones. Free Rad. Biol. Med., 20, 35-43.
18. Vinson, J.A., Dabbagh, Y.A., Serry, M.M. and Jang, J.H. (1995) Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease. J. Agr. Food Chem., 43, 2800-2802.
19. Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F. and Castelli, F. (1995) Flavonoids as antioxidants agents: importance of their interaction with biomembranes. Free Rad. Biol. Med., 19, 481-486.