Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions

Neuroscience Letters

Volumn 428, Issue 2-3, 2007, Pages 72-76

  Yamauchi, Yosuke ^a   Izumi, Takaya ^a   Unemura, Kazuhiro ^a   Uenishi, Yoshie ^a   Nakagawa, Takayuki ^a   Kaneko, Shuji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Acidic condition; MDMA; SERT; Xenopus oocytes

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CITALOPRAM; LACTIC ACID; SEROTONIN TRANSPORTER;

ARTICLE; BINDING AFFINITY; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; DRUG INHIBITION; HYPERPOLARIZATION; HYPERTHERMIA; KINETICS; MEMBRANE POTENTIAL; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SEROTONIN UPTAKE; THERMOREGULATION; XENOPUS;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MEMBRANE POTENTIALS; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; NOREPINEPHRINE; OOCYTES; PROTONS; RATS; SEROTONIN; SEROTONIN AGENTS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 35748948057     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.09.037     Document Type: Article

References (18)

1. Cao Y., Li M., Mager S., and Lester H.A. Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters. J. Neurosci. 18 (1998) 7739-7749
2. + permeation and pH regulation at a mammalian serotonin transporter. J. Neurosci. 17 (1997) 2257-2266
3. Eshleman A.J., Carmolli M., Cumbay M., Martens C.R., Neve K.A., and Janowsky A. Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. J. Pharmacol. Exp. Ther. 289 (1999) 877-885
4. Gramsbergen J.B., and Cumming P. Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats. Neurochem. Int. 51 (2007) 8-15
5. Green A.R., Mechan A.O., Elliott J.M., O'Shea E., and Colado M.I. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol. Rev. 55 (2003) 463-508
6. Greene S.L., Dargan P.I., O'connor N., Jones A.L., and Kerins M. Multiple toxicity from 3,4-methylenedioxymethamphetamine ("ecstasy"). Am. J. Emerg. Med. 21 (2003) 121-124
7. Lester H.A., Cao Y., and Mager S. Listening to neurotransmitter transporters. Neuron. 17 (1996) 807-810
8. + channel determined by construction of multimeric cDNAs. Neuron 9 (1992) 861-871
9. Mager S., Cao Y., and Lester H.A. Measurement of transient currents from neurotransmitter transporters expressed in Xenopus oocytes. Methods Enzymol. 296 (1998) 551-566
10. Mager S., Min C., Henry D.J., Chavkin C., Hoffman B.J., Davidson N., and Lester H.A. Conducting states of a mammalian serotonin transporter. Neuron 12 (1994) 845-859
11. Rudnick G., and Clark J. From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim. Biophys. Acta. 1144 (1993) 249-263
12. Rudnick G., and Wall S.C. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 1817-1821
13. Saldaña S.N., and Barker E.L. Temperature and 3,4-methylenedioxymethamphetamine alter human serotonin transporter-mediated dopamine uptake. Neurosci. Lett. 354 (2004) 209-212
14. Sonders M.S., and Amara S.G. Channels in transporters. Curr. Opin. Neurobiol. 6 (1996) 294-302
15. Sonders M.S., Zhu S.J., Zahniser N.R., Kavanaugh M.P., and Amara S.G. Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J. Neurosci. 17 (1997) 960-974
16. Sprague J.E., Everman S.L., and Nichols D.E. An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19 (1998) 427-441
17. Wilhelm C.J., Johnson R.A., Eshleman A.J., and Janowsky A. Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux. J. Neurochem. 96 (2006) 1149-1159
18. --dependent neurotransmitter transporters. Nature 437 (2005) 215-223