Staphylococcus aureus leucotoxin LukM/F' is secreted and stimulates neutralising antibody response in the course of intramammary infection

Veterinary Research

Volumn 38, Issue 5, 2007, Pages 685-696

  Rainard, Pascal ^a  

^a UR1282   (France)

Author keywords

Leucotoxin; Mastitis; Ruminants; Staphylococcus aureus

Indexed keywords

LEUKOTOXIN; NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS TOXIN;

ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN DETECTION; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BREAST ABSCESS; BREAST NECROSIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL INFECTION; INFECTION PREVENTION; LEUKOCYTE ACTIVATION; MAMMARY GLAND; MILK PRODUCTION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTIBODIES, BACTERIAL; EXOTOXINS; FEMALE; GOAT DISEASES; GOATS; MASTITIS; MILK; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS;

CAPRA HIRCUS; STAPHYLOCOCCUS AUREUS;

EID: 35748947231     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1051/vetres:2007026     Document Type: Article

References (22)

1. Barrio M.B., Rainard P., Prevost G., LukM/LukF'-PV is the most active Staphylococcus aureus leukotoxin on bovine neutrophils, Microbes Infect. (2006) 8:2068-2074.
2. Bergonier D., de Cremoux R., Rupp R., Lagriffoul G., Berthelot X., Mastitis of dairy small ruminants, Vet. Res. (2003) 34:689-716.
3. Bronner S., Jehl F., Peter J.D., Ploy M.C., Renault C., Arvis P., Monteil H., Prevost G., Moxifloxacin efficacy and vitreous penetration in a rabbit model of Staphylococcus aureus endophthalmitis and effect on gene expression of leucotoxins and virulence regulator factors, Antimicrob. Agents Chemother. (2003) 47:1621-1629.
4. Contreras A., Luengo C., Sanchez A., Corrales J.C., The role of intramammary pathogens in dairy goats, Livest. Prod. Sci. (2003) 79:273-283.
5. Etienne J., Panton-Valentine leukocidin: a marker of severity for Staphylococcus aureus infection? Clin. Infect. Dis. (2005) 41:591-593.
6. Fueyo J.M., Mendoza M.C., Rodicio M.R., Muniz J., Alvarez M.A., Martin M.C., Cytotoxin and pyrogenic toxin superantigen gene profiles of Staphylococcus aureus associated with subclinical mastitis in dairy cows and relationships with macrorestriction genomic profiles, J. Clin. Microbiol. (2005) 43:1278-1284.
7. Genestier A.L., Michallet M.C., Prevost G., Bellot G., Chalabreysse L., Peyrol S., Thivolet F., Etienne J., Lina G., Vallette F.M., Vandenesch F., Genestier L., Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils, J. Clin. Invest. (2005) 115:3117-3127.
8. Gillet Y., Issartel B., Vanhems P., Fournet J.C., Lina G., Bes M., Vandenesch F., Piémont Y., Brousse N., Floret D., Etienne J., Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients, Lancet (2002) 359:753-759.
9. König B., Prévost G., Piémont Y., König W., Effects of Staphylococcus aureus leukocidins on inflammatory mediator release from human granulocytes, J. Infect. Dis. (1995) 171:607-613.
10. Loeffler D.A., Norcross N.L., Enzyme-linked immunosorbent assay for detection of milk immunoglobulins to leukocidin toxin of Staphylococcus aureus, Am. J. Vet. Res. (1985) 46:1728-1732.
11. Loeffler D.A., Creasy M.T., Norcross N.L., Paape M.J., Enzyme-linked immunosorbent assay for detection of leukocidin toxin from Staphylococcus aureus in bovine milk samples, J. Clin. Microbiol. (1988) 26:1331-1334.
12. Paape M., Mehrzad J., Zhao X., Detilleux J., Burvenich C., Defense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes, J. Mammary Gland Biol. Neoplasia (2002) 7:109-121.
13. Poutrel B., Rainard P., Predicting the probability of quarter infection (by major pathogens) from somatic cell concentration, Am. J. Vet. Res. (1982) 43:1296-1299.
14. Prévost G., The bi-component staphylococcal leucocidins and γ-haemolysins (toxins), in: Alouf J.E., Freer J.H. (Eds.), The comprehensive sourcebook of bacterial protein toxins, Academic Press, London, 1999, pp. 402-418.
15. Prévost G., Mourey L., Colin D.A., Menestrina G., Staphylococcal pore-forming toxins, Curr. Top. Microbiol. Immunol. (2001) 257:53-83.
16. Rainard P., Corrales J.C., Barrio M.B., Cochard T., Poutrel B., Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV leukotoxin, Clin. Diagn. Lab. Immunol. (2003) 10:272-277.
17. Rainard P., Riollet C., Innate immunity of the bovine mammary gland, Vet. Res. (2006) 37:369-400.
18. Sutra L., Poutrel B., Virulence factors involved in the pathogenesis of bovine intramammary infections due to Staphylococcus aureus, J. Med. Microbiol. (1994) 40:79-89.
19. Tollersrud T., Kampen A.H., Kenny K., Staphylococcus aureus enterotoxin D is secreted in milk and stimulates specific antibody responses in cows in the course of experimental intramammary infection, Infect. Immun. (2006) 74:3507-3512.
20. Von Eiff C., Friedrich A.W., Peters G., Becker K., Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus, Diagn. Microbiol. Infect. Dis. (2004) 49:157-162.
21. Yamada T., Tochimaru N., Nakasuji S., Hata E., Kobayashi H., Eguchi M., Kaneko J., Kamio Y., Kaidoh T., Takeuchi S., Leukotoxin family genes in Staphylococcus aureus isolated from domestic animals and prevalence of lukM-lukF-PV genes by bacteriophages in bovine isolates, Vet. Microbiol. (2005) 110:97-103.
22. Younis A., Krifucks O., Fleminger G., Heller E.D., Gollop N., Saran A., Leitner G., Staphylococcus aureus leucocidin, a virulence factor in bovine mastitis, J. Dairy Res. (2005) 72:188-194.