Altered storage of proteases in mast cells from mice lacking heparin: A possible role for heparin in carboxypeptidase A processing

Biological Chemistry

Volumn 383, Issue 5, 2002, Pages 793-801

  Henningsson, Frida ^a   Ledin, Johan ^a   Lunderius, Carolina ^a   Wilén, Maria ^a   Hellman, Lars ^a   Pejler, Gunnar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Carboxypeptidase; Chymase; Heparin; Mast cell; NDST 2; Tryptase

Indexed keywords

CARBOXYPEPTIDASE A; CHONDROITIN SULFATE; CHYMASE; HEPARIN; INTERLEUKIN 3; MESSENGER RNA; POLYSACCHARIDE; PROTEINASE; SULFOTRANSFERASE; TRYPTASE; ACTIN; AMIDASE; CARBOXYPEPTIDASE; GLYCOSAMINOGLYCAN; MCPT6 PROTEIN, MOUSE; NDST2 PROTEIN, MOUSE; RNA; SERINE PROTEINASE; TPSAB1 PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; BONE MARROW; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE TARGETING; MAST CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PROCESSING; SECRETORY GRANULE; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; ELECTRON MICROSCOPY; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM; ULTRASTRUCTURE; WESTERN BLOTTING;

ACTINS; AMIDOHYDROLASES; ANIMAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; BONE MARROW CELLS; CARBOXYPEPTIDASES; CELLS, CULTURED; CHONDROITIN SULFATES; GLYCOSAMINOGLYCANS; HEPARIN; INTERLEUKIN-3; MAST CELLS; MICE; MICROSCOPY, ELECTRON; RNA; SERINE ENDOPEPTIDASES; SULFOTRANSFERASES; SUPPORT, NON-U.S. GOV'T; ANIMALS; CARBOXYPEPTIDASES A; TRYPTASES;

ANIMALIA;

EID: 0035985063     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.083     Document Type: Article

References (53)

1. Molecular cloning and expression of a third member of the heparan Sulfate/Heparin GlcNAc N-Deacetylase/ N-sulfotransferase family
2. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
3. Functions of cell surface heparan sulfate proteoglycans
4. 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency
5. Processing of procarboxypeptidase A and other zymogens in murine mast cells
6. Glycosaminoglycans in rat mucosal mast cells
7. cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N- deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin
8. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
9. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand
10. Mechanism for activation of mouse mast cell tryptase: Dependence on heparin and acidic pH for formation of active tetramers of mouse mast cell protease 6
11. Heparin antagonists are potent inhibitors of mast cell tryptase
12. Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease 6. Formation of active tryptase monomers in the presence of low molecular weight heparin
13. Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase
14. Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo
15. The induction of a prolonged increase in microvascular permeability by human mast cell chymase
16. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: Selective enhancement of eosinophil recruitment by histamine
17. Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6
18. Regulation and function of mast cell proteases in inflammation
19. Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases
20. Heparin is essential for the storage of specific granule proteases in mast cells
21. Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse
22. Human mast cells and basophils as sources of cytokines
23. Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes
24. Coculture of interleukin 3-dependent mouse mast cells with fibroblasts results in a phenotypic change of the mast cells
25. Regulated diversity of heparan sulfate
26. More to 'heparin' than anticoagulation
27. Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases
28. The conversion of recombinant human mast cell prochymase to enzymatically active chymase by dipeptidyl peptidase I is inhibited by heparin and histamine
29. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells
30. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7
31. Mast cells
32. Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase A
33. Inhaled tryptase causes bronchoconstriction in sheep via histamine release
34. Human prochymase activation. A novel role for heparin in zymogen processing
35. Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line
36. Interaction of heparin with rat mast cell protease 1
37. An immunocytochemical approach to the demonstration of intracellular processing of mast cell carboxypeptidase
38. Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes
39. Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan
40. Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass
41. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases
42. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker
43. Complexes of heparin proteoglycans, chondroitin sulfate E proteoglycans, and [3H]diisopropyl fluorophosphate-binding proteins are exocytosed from activated mouse bone marrow-derived mast cells
44. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease
45. Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat
46. Formation of anhydrosugars in the chemical depolymerization of heparin
47. Mast cell procarboxypeptidase A. Molecular modeling and biochemical characterization of its processing within secretory granules
48. Recent advances in the cellular and molecular biology of mast cells
49. Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases
50. Amino acid sequence of a mouse mucosal mast cell protease
51. Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor
52. Roles of mast cells and basophils in innate and acquired immunity
53. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice