Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease

Annals of the New York Academy of Sciences

Volumn 1110, Issue , 2007, Pages 193-200

  Yin, Xiaoming ^a   Latif, Rauf ^a   Tomer, Yaron ^b   Davies, Terry F ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Autoimmune thyroid disease; Epigenetics; Graves' disease; Hashimoto's thyroiditis; X chromosome inactivation

Indexed keywords

AUTOIMMUNE DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; DNA SEQUENCE; EPIGENETICS; FEMALE; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; RISK FACTOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THYROID DISEASE; X CHROMOSOME INACTIVATION;

EID: 35748941353     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1423.021     Document Type: Conference Paper

References (23)

1. BARBESINO, G., Y. TOMER, E.S. CONCEPCION, et al. 1998. Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease. J. Clin. Endocrinol. Metab. 83: 3290-3295.
2. IMRIE, H., B. VAIDYA, P. PERROS, et al. 2001. Evidence for a Graves' disease susceptibility locus at chromosome Xp11 in a United Kingdom population. J. Clin. Endocrinol. Metab. 86: 626-630.
3. TOMER, Y., G. BARBESINO, D.A. GREENBERG, et al. 1999. Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. J. Clin. Endocrinol. Metab. 84: 4656-4664.
4. TAYLOR, J.C., S.C. GOUGH, P.J. HUNT, et al. 2006. A genome-wide screen in 1119 relative pairs with autoimmune thyroid disease. J. Clin. Endocrinol. Metab. 91: 646-653.
5. TOMER, Y., Y. BAN, E. CONCEPCION, et al. 2003. Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am. J. Hum. Genet. 73: 736-747.
6. MEDEIROS, C.C., S.H. MARINI, M.T. BAPTISTA, et al. 2000. Turner's syndrome and thyroid disease: a transverse study of pediatric patients in Brazil. J. Pediatr. Endocrinol. Metab. 13: 357-362.
7. INVERNIZZI, P., M. MIOZZO, C. SELMI, et al. 2005. X chromosome monosomy: a common mechanism for autoimmune diseases. J. Immunol. 175: 575-578.
8. LYON, M.F. 1961. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190: 372-373.
9. CARREL, L. & H.F. WILLARD. 2005. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434: 400-404.
10. BRIX, T.H., G.P. KNUDSEN, M. KRISTIANSEN, et al. 2005. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. J. Clin. Endocrinol. Metab. 90: 5949-5953.
11. OZCELIK, T., E. UZ, C.B. AKYERLI, et al. 2006. Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity. Eur. J. Hum. Genet. 14: 791-797.
12. ALLEN, R.C., H.Y. ZOGHBI, A.B. MOSELEY, et al. 1992. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am. J. Hum. Genet. 51: 1229-1239.
13. SHARP, A., D. ROBINSON & P. JACOBS. 2000. Age- and tissue-specific variation of X chromosome inactivation ratios in normal women. Hum. Genet. 107: 343-349.
14. LYON, M.F. 2006. Do LINEs have a role in X-chromosome inactivation? J. Biomed. Biotechnol. 2006: 59746.
15. BACHER, C.P., M. GUGGIARI, B. BRORS, et al. 2006. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat. Cell Biol. 8: 293-299.
16. XU, N., C.L. TSAI & J.T. LEE. 2006. Transient homologous chromosome pairing marks the onset of X inactivation. Science 311: 1149-1152.
17. CHADWICK, L.H., L.M. PERTZ, K.W. BROMAN, et al. 2006. Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval. Genetics 173: 2103-2110.
18. NAUMOVA, A.K., L. OLIEN, L.M. BIRD, et al. 1998. Genetic mapping of X-linked loci involved in skewing of X chromosome inactivation in the human. Eur. J. Hum. Genet. 6: 552-562.
19. PEGORARO, E., J. WHITAKER, P. MOWERY- RUSHTON, et al. 1997. Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28. Am. J. Hum. Genet. 61: 160-170.
20. PLENGE, R.M., B.D. HENDRICH, C. SCHWARTZ, et al. 1997. A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Nat. Genet. 17: 353-356.
21. CHITNIS, S., J. MONTEIRO, D. GLASS, et al. 2000. The role of X-chromosome inactivation in female predisposition to autoimmunity. Arthritis Res. 2: 399-406.
22. DE LA CASA-ESPERON, E., J.C. LOREDO-OSTI, F. PARDO-MANUEL DE VILLENA, et al. 2002. X chromosome effect on maternal recombination and meiotic drive in the mouse. Genetics 161: 1651-1659.
23. RHODEN, K.J., K. UNGER, G. SALVATORE, et al. 2006. RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma. J. Clin. Endocrinol. Metab. 91: 2414-2423.