High shear mixing granulation of ibuprofen and β-cyclodextrin: Effects of process variables on ibuprofen dissolution

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Ghorab, Mohamed K ^a,b   Adeyeye, Moji Christianah ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b Solids Pharmaceutical R and D Chemical and Pharmaceutical Development   (United States)

Author keywords

Beta cyclodextrin; Complexation; Dissolution; Granulation; Ibuprofen

Indexed keywords

2 PROPANOL; BETA CYCLODEXTRIN; IBUPROFEN; MAGNESIUM STEARATE; SOLVENT; WATER; BETA CYCLODEXTRIN DERIVATIVE; EXCIPIENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; BINDING KINETICS; CENTRIFUGATION; CONTROLLED STUDY; CRUSHING STRENGTH; DRUG GRANULATION; DRUG SOLUBILITY; EVAPORATION; FLOW MEASUREMENT; GRAVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL ANALYSIS; MIXER; PARTICLE SIZE; SCALE UP; SHEAR RATE; TABLET COMPRESSION; TABLET HARDNESS; TEMPERATURE; TORQUE; VELOCITY; CHEMISTRY; COMPRESSIVE STRENGTH; DRUG FORMULATION; FLOW KINETICS; MECHANICAL STRESS; METHODOLOGY; PHARMACEUTICS; POWDER; SOLUBILITY; TIME; VOLATILIZATION;

2-PROPANOL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BETA-CYCLODEXTRINS; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG COMPOUNDING; EXCIPIENTS; IBUPROFEN; POWDERS; RHEOLOGY; SOLUBILITY; SOLVENTS; STRESS, MECHANICAL; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; TORQUE; VOLATILIZATION; WATER;

EID: 35649000390     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804084     Document Type: Article

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