Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 5, 2007, Pages 1110-1117

  Lee, June Hyuk ^a   Chang, Hun Soo ^a   Kim, Ji Hyun ^a   Park, Se Min ^a   Lee, Yong Mok ^a   Uh, Soo Taek ^a   Rhim, Taiyoun ^a   Chung, Il Yup ^b   Kim, Yong Hoon ^a   Park, Byung Lae ^c   Park, Choon Sik ^a   Shin, Hyoung Doo ^c  

^a Soonchunhyang University   (South Korea)

^b Hanyang University   (South Korea)

^c SNP Genetics Inc   (South Korea)

Author keywords

Asthma; CC chemokine receptor 3; eosinophilia; IL 5 receptor ; single nucleotide polymorphism

Indexed keywords

CHEMOKINE RECEPTOR CCR3; INTERLEUKIN 5 RECEPTOR; INTERLEUKIN 5 RECEPTOR A; INTERLEUKIN 5 RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; EOSINOPHIL; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASTHMA; CHILD; EOSINOPHILIA; EOSINOPHILS; FEMALE; HUMANS; INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT; LEUKOCYTE COUNT; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CCR3;

EID: 35648981092     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.08.041     Document Type: Article

References (41)

1. Davies D.E., Wicks J., Powell R.M., Puddicombe S.M., and Holgate S.T. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 111 (2003) 215-225
2. Hamid Q. Eosinophils in allergic inflammation. J Allergy Clin Immunol 113 (2004) 182-184
3. Ciprandi G., Cirillo I., Vizzaccaro A., Milanese M., and Tosca M.A. Airway function and nasal inflammation in seasonal allergic rhinitis and asthma. Clin Exp Allergy 34 (2004) 891-896
4. Rothenberg M.E., Mishra A., Brandt E.B., and Hogan S.P. Gastrointestinal eosinophils. Immunol Rev 179 (2001) 139-155
5. Bousquet J., Chanez P., Lacoste J.Y., Barneon G., Ghavanian N., Enander I., et al. Eosinophilic inflammation in asthma. N Engl J Med 323 (1990) 1033-1039
6. Kay A.B. The role of eosinophils in the pathogenesis of asthma. Trends Mol Med 11 (2005) 148-152
7. Zeibecoglou K., Ying S., Yamada T., North J., Burman J., Bungre J., et al. Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects. J Allergy Clin Immunol 103 (1999) 99-106
8. Mould A.W., Matthaei K.I., Young L.G., and Foster P.S. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J Clin Invest 99 (1997) 1064-1071
9. Wang J., Palmer K., Lotvall J., Milan S., Lei X.-F., Matthaei K.I., et al. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 102 (1998) 1132-1141
10. Combadiere C., Ahuja S.K., and Murphy P.M. Cloning and functional expression of a human eosinophil CC chemokine receptor. J Biol Chem 270 (1995) 16491-16494
11. Heath H., Qin S., Rao P., Wu L., La Rosa G., Kassam N., et al. Chemokine receptor usage by human eosinophils: the importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 99 (1997) 178-184
12. Ravensberg A.J., Ricciardolo F.L., van Schadewijk A., Rabe K.F., Sterk P.J., Hiemstra P.S., et al. Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. J Allergy Clin Immunol 115 (2005) 779-785
13. Ying S., Robinson D.S., Meng Q., Rottman J., Kennedy R., Ringler D.J., et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma: association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 27 (1997) 3507-3516
14. Daugherty B.L., and Springer M.S. The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics 41 (1997) 294-295
15. Samson M., Soularue P., Vassart G., and Parmentier M. The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. Genomics 36 (1996) 522-526
16. Cookson W.O., Ubhi B., Lawrence R., Abecasis G.R., Walley A.J., Cox H.E., et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 27 (2001) 372-373
17. Lee Y.A., Wahn U., Kehrt R., Tarani L., Businco L., Gustafsson D., et al. A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet 26 (2000) 470-473
18. Ober C., Tsalenko A., Parry R., and Cox N.J. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 67 (2000) 1154-1162
19. Bradley B.L., Azzawi M., Jacobson M., Assoufi B., Collins J.V., Irani A.M., et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 88 (1991) 661-674
20. Laitinen L.A., Laitinen A., Haahtela T., Vilkka V., Spur B.W., and Lee T.H. Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 341 (1993) 989-990
21. Isobe M., Kumura Y., Murata Y., Takaki S., Tominaga A., Takatsu K., et al. Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics 14 (1992) 755-758
22. Kotsimbos A.T., and Hamid Q. IL-5 and IL-5 receptor in asthma. Mem Inst Oswaldo Cruz 92 suppl 2 (1997) 75-91
23. Murata Y., Takaki S., Migita M., Kikuchi Y., Tominaga A., and Takatsu K. Molecular cloning and expression of the human interleukin 5 receptor. J Exp Med 175 (1992) 341-351
24. Boulay J.L., and Paul W.E. The interleukin-4 family of lymphokines. Curr Opin Immunol 4 (1992) 294-298
25. Yasruel Z., Humbert M., Kotsimbos T.C., Ploysongsang Y., Minshall E., Durham S.R., et al. Membrane-bound and soluble alpha IL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics. Am J Respir Crit Care Med 155 (1997) 1413-1418
26. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis 136 (1987) 225-244
27. Park C.S., Choi E.N., Kim J.S., Choi Y.S., Rhim T.Y., Chang H.S., et al. Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5. Int Arch Allergy Immunol 136 (2005) 295-302
28. Weil G.J., and Chused T.M. Eosinophil autofluorescence and its use in isolation and analysis of human eosinophils using flow microfluorometry. Blood 57 (1981) 1099-1104
29. Guo S., and Thompson E. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48 (1992) 361-372
30. Hedric P.W. Gametic disequilibrium measures: proceed with caution. Genetics 117 (1978) 331-341
31. Kaplan M., and Weir B.S. Expected behavior of conditional linkage disequilibrium. Am J Hum Genet 51 (1992) 333-343
32. Stephan M., Smith N.J., and Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68 (2001) 978-989
33. Nyholt D.R. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74 (2004) 765-769
34. Fukunaga K., Asano K., Mao X.-Q., Gao P.-S., Roberts M.H., Oguma T., et al. Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics. Eur Respir J 17 (2001) 59-63
35. Unoki M., Furuta S., Onouchi Y., Watanabe O., Doi S., Fujiwara H., et al. Association studies of 33 single nucleotide polymorphism (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the tromboxane A2 receptor gene. Hum Genet 106 (2000) 440-446
36. Zimmermann N., Bernstein J.A., and Rothernberg M.E. Polymorphisms in the human CC chemokine receptor-3 gene. Biochim Biophys Acta 1442 (1998) 170-176
37. Cheong H.S., Kim L.H., Park B.L., Choi Y.H., Park H.S., Hong S.J., et al. Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. J Hum Genet 50 (2005) 628-634
38. Gauvreau G.M., Watson R.W., and O'Byrne P.M. Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am J Respir Crit Care Med 160 (1999) 640-647
39. van Rensen E.L., Stirling R.G., Scheerens J., Staples K., Sterk P.J., Barnes P.J., et al. Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax 56 (2001) 935-940
40. Zimmermann N., Daugherty B.L., Kavanaugh J.L., El-Awar F.Y., Moulton E.A., and Rothenberg M.E. Analysis of the CC chemokine receptor 3 gene reveals a complex 5′ exon organization, a functional role for untranslated exon 1, and a broadly active, promoter with eosinophil-selective elements. Blood 96 (2000) 2346-2354
41. Zimmermann N., Colyer J.L., Koch L.E., and Rothenberg M.E. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1. BMC Immunol 6 (2005) 7