Influence of irbesartan on expression of ILK and its relationship with epithelial-mesenchymal transition in mice with unilateral ureteral obstruction

Acta Pharmacologica Sinica

Volumn 28, Issue 11, 2007, Pages 1810-1818

  Liu, Bi Cheng ^a   Xia, Hui Ling ^a   Wu, Ji Ning ^a   Zhang, Xiao Liang ^a   Liu, Dian Ge ^a   Gong, Yu Xiang ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Integrin linked kinase; Irbesartan; Tubulointerstitial fibrosis

Indexed keywords

DRUG VEHICLE; INTEGRIN LINKED KINASE; IRBESARTAN; SMOOTH MUSCLE ACTIN; SODIUM CHLORIDE; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPITHELIUM; GENE TARGETING; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; MESENCHYME; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; URETER OBSTRUCTION;

ACTINS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BIPHENYL COMPOUNDS; CADHERINS; CELL TRANSDIFFERENTIATION; DOWN-REGULATION; EPITHELIAL CELLS; FIBROSIS; KIDNEY; MALE; MICE; NEPHRITIS, INTERSTITIAL; PROTEIN-SERINE-THREONINE KINASES; RANDOM ALLOCATION; RNA, MESSENGER; TETRAZOLES; URETERAL OBSTRUCTION;

EID: 35648978184     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00649.x     Document Type: Article

References (26)

1. Faulkner JL, Szcykalski LM, Springer F, Barnes JL. Origin of interstitial fibroblasts in an accelerated model of angiotensin II- induced renal fibrosis. Am J Pathol 2005 167 : 1193 205.
2. Yang J, Shultz RW, Mars WM, Wegner RE, Li Y, Dai C, et al. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 2002 110 : 1525 38.
3. Fan JM, Ng YY, Hill PA, Nikolic-Paterson DJ, Mu W, Atkins RC, et al. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 1999 56 : 1455 67.
4. Li Y, Yang J, Dai C, Wu C, Liu Y. Role of integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 2003 112 : 503 16.
5. Wu CY. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta 2004 1692 : 55 62.
6. Ruiz-Torres MP, Lopez-Ongil S, Griera M, Diez-Marques ML, Rodriguez-Puyol M, Rodriguez-Puyol D. The accumulation of extracellular matrix in the kidney: consequences on cellular function. J Nephrol 2005 18 : 334 40.
7. Kretzler M, Teixeira VP, Unschuld PG, Cohen CD, Wanke R, Edenhofer I, et al. Integrin-linked kinase as a candidate downstream effector in proteinuria. FASEB J 2001 15 : 1843 5.
8. Guo L, Sanders PW, Woods A, Wu C. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. Am J Pathol 2001 159 : 1735 42.
9. Ruiz-Ortega M, Ruperez M, Esteban V, Egido J. Molecular mechanisms of angiotensin II-induced vascular injury. Curr Hypertens Rep 2003 5 : 73 9.
10. Misseri R, Rink RC, Meldrum DR, Meldrum KK. Inflammatory mediators and growth factors in obstructive renal injury. J Surg Res 2004 119 : 149 59.
11. Ruiz-Ortega M, Ruperez M, Esteban V, Rodriguez-Vita J, Sanchez-Lopez E, Carvajal G, et al. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney disease. Nephrol Dial Transplant 2006 21 : 16 20.
12. Remuzzi G, Perico N, Macia M, Ruggenenti P. The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease. Kidney Int 2005 68 (Suppl 99 S57 65.
13. Klahr S, Morrissey J. Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 2002 283 : F861 75.
14. Aros C, Remuzzi G. The renin-angiotensin system in progression, remission and regression of chronic nephropathies. J Hyperten 2002 20 (Suppl 3 S45 43.
15. Zeisberg M, Kaluri R. The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 2004 82 : 175 81.
16. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002 110 : 341 50.
17. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001 159 : 1465 75.
18. Lan HY. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 2003 12 : 25 9.
19. Nawshad A, Lagamba D, Polad A, Hay ED. Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 2005 179 : 11 23.
20. Liu YH. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004 15 : 1 12.
21. Bernardo RI, Richard JJ, Jaime HA. Tubulointerstitial damage and progression of renal failure. Kidney Int 2005 68 (Suppl 99 S82 6.
22. Ha H, Lee HB. Reactive oxygen species and matrix remodeling in diabetic kidney. J Am Soc Nephrol 2003 14 : S246 9.
23. Yang J, Dai C, Liu Y. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol 2002 13 : 2464 77.
24. Chen L, Liu BC, Zhang XL, Zhang JD, Liu H, Li MX. Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells. Acta Pharmacol Sin 2006 27 : 1029 36.
25. Green K, Watt F. Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol 2004 16 : 465 9.
26. Oloumi A, McPhee T, Dedhar S. Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta 2004 1691 : 1 15.