Dexamethasone treatment does not inhibit fibroproliferation in chronic lung disease of prematurity

European Respiratory Journal

Volumn 21, Issue 5, 2003, Pages 842-847

  Dik, W A ^a   Versnel, M A ^a   Naber, B A ^a   Janssen, D J ^a   van Kaam, A H ^b   Zimmermann, L J I ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Bronchoalveolar lavage; Chronic lung disease of prematurity; Dexamethasone; Fibroblast proliferation; Platelet derived growth factor

Indexed keywords

6,7 DIMETHOXY 2 PHENYLQUINOXALINE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; BLEOMYCIN; DEXAMETHASONE; ERYTHROMYCIN; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR BB; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL PROLIFERATION; CHRONIC LUNG DISEASE; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIGESTIVE SYSTEM PERFORATION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; FEMALE; FIBROBLAST; GRAM NEGATIVE INFECTION; GROWTH RETARDATION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INFANT; INFLAMMATION; INFLAMMATORY CELL; LUNG FIBROSIS; LUNG FUNCTION; LUNG LAVAGE; MALE; MITOGENICITY; NEUROLOGIC DISEASE; PREMATURITY; PRIORITY JOURNAL; RISK ASSESSMENT;

ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; DEXAMETHASONE; FIBROBLASTS; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; PULMONARY FIBROSIS; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 0038394578     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00069002     Document Type: Article

References (35)

1. Merritt TA, Cochrane CG, Holcomb K, et al. Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia. J Clin Invest 1983; 72: 656-666.
2. Ogden BE, Murphy SA, Saunders GC, Pathak D, Johnson JD. Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. Am Rev Respir Dis 1984; 130: 817-821.
3. Pierce MR, Bancalari E. The role of inflammation in the pathogenesis of bronchopulmonary dysplasia. Pediatr Pulmonol 1995; 19: 371-378.
4. McAnulty RJ, Laurent GJ. Pathogenesis of lung fibrosis and potential new therapeutic strategies. Exp Nephrol 1995; 3: 96-107.
5. Cherukupalli K, Larson JE, Rotschild A, Thurlbeck WM. Biochemical, clinical, and morphologic studies on lungs of infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1996; 22: 215-229.
6. Gerdes JS, Harris MC, Polin RA. Effects of dexamethasone and indomethacin on clastase, alpha 1-proteinase inhibitor, and fibronectin in bronchoalveolar lavage fluid from neonates. J Pediatr 1988; 113: 727-731.
7. Kotecha S, Wangoo A, Silverman M, Shaw RJ. Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity. J Pediatr 1996; 128: 464-469.
8. Yoder MC Jr, Chua R, Tepper R. Effect of dexamethasone on pulmonary inflammation and pulmonary function of ventilator-dependent infants with bronchopulmonary dysplasia. Am Rev Respir Dis 1991; 143: 1044-1048.
9. Co E, Chari G, McCulloch K, Vidyasagar D. Dexamethasone treatment suppresses collagen synthesis in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1993; 16: 36-40.
10. Marshall RP, Bellingan G, Webb S, et al. Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome. Am J Respir Crit Care Med 2000; 162: 1783-1788.
11. Walsh J, Absher M, Kelley J. Variable expression of platelet-derived growth factor family proteins in acute lung injury. Am J Respir Cell Mol Biol 1993; 9: 637-644.
12. Haynes AR, Shaw RJ. Dexamethasone-induced increase in platelet-derived growth factor (B) mRNA in human alveolar macrophages and myelomonocytic HL60 macrophage-like cells. Am J Respir Cell Mol Biol 1992; 7: 198-206.
13. Bjermer L, Lundgren R, Hallgren R. Hyaluronan and type III procollagen peptide concentrations in bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis. Thorax 1989; 44: 126-131.
14. Bancalari E, Abdenour GE, Feller R, Gannon J. Bronchopulmonary dysplasia: clinical presentation. J Pediatr 1979; 95: 819-823.
15. Grigg J, Arnon S, Silverman M. Fractional processing of sequential bronchoalveolar lavage fluid from intubated babies. Eur Respir J 1992; 5: 727-732.
16. Oliver MH, Harrison NK, Bishop JE, Cole PJ, Laurent GJ. A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors. J Cell Sci 1989: 92: 513-518.
17. IJsselstijn H, Zimmermann LJ, Bunt JE, de Jongste JC, Tibboel D. Prospective evaluation of surfactant composition in bronchoalveolar lavage fluid of infants with congenital diaphragmatic hernia and of age-matched controls. Crit Care ed 1998; 26: 573-580.
18. de Blic J, Midulla F, Barbato A, et al. Bronchoalveolar lavage in children. Eur Respir J 2000; 15: 217-231.
19. Rice AB, Moomaw CR, Morgan DL, Bonner JC. Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats. Am J Pathol 1999; 155: 213-221.
20. Barrington KJ, Finer NN. Treatment of bronchopulmonary dysplasia. A review. Clin Perinatol 1998; 25: 177-202.
21. Barrington KJ. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr 2001; 1: 1-9.
22. Currie AE, Kelly M, Vyas JR, Pandya H, Field D, Kotecha S. Fibroblast mitogenic activity of lung lavage fluid from infants with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed 2002; 86: F193-F197.
23. Groneck P, Reuss D, Gotze-Speer B, Speer CP. Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. J Pediatr 1993; 122: 938-944.
24. Warshamana GS, Martinez S, Lasky JA, Corti M, Brody AR. Dexamethasone activates expression of the PDGF-alpha receptor and induces lung fibroblast proliferation. Am J Physiol 1998; 274: L499-L507.
25. Brenner RE, Felger D, Winter C, Christiansen A, Hofmann D, Bartmann P. Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts. Pediatr Pulmonol 2001; 32: 1-7.
26. Fabisiak JP, Evans JN, Kelley J. Increased expression of PDGF-B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia. Am J Respir Cell Mol Biol 1989; 1: 181-189.
27. 2. Am J Physiol 1992; 262: L140-L146.
28. Yoshida M, Sakuma-Mochizuki J, Abe K, et al. In vivo gene transfer of an extracellular domain of platelet-derived growth factor beta receptor by the HVJ-liposome method ameliorates bleomycin-induced pulmonary fibrosis. Biochem Biophys Res Commun 1999; 265: 503-508.
29. Song E, Ouyang N, Horbelt M, Antus B, Wang M, Exton MS. Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol 2000; 204: 19-28.
30. Sterling KM Jr, Harris MJ, Mitchell JJ, DiPetrillo TA, Delaney GL, Cutroneo KR. Dexamethasone decreases the amounts of type I procollagen mRNAs in vivo and in fibroblast cell cultures. J Biol Chem 1983; 258: 7644-7647.
31. Cockayne D, Sterling KM Jr, Shull S, Mintz KP, Illeyne S, Cutroneo KR. Glucocorticoids decrease the synthesis of type I procollagen mRNAs. Biochemistry 1986; 25: 3202-3209.
32. Crofton PM, Shrivastava A, Wade JC, et al. Effects of dexamethasone treatment on bone and collagen turnover in preterm infants with chronic lung disease. Pediatr Res 2000; 48: 155-162.
33. Chen Y, Martinez MA, Frank L. Prenatal dexamethasone administration to premature rats exposed to prolonged hyperoxia: a new rat model of pulmonary fibrosis (bronchopulmonary dysplasia). J Pediatr 1997; 130: 409-416.
34. Clark JG, Milberg JA, Steinberg KP, Hudson LD. Type III procollagen peptide in the adult respiratory distress syndrome. Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death. Ann Intern Med 1995; 122: 17-23.
35. Harrison NK, McAnulty RJ, Kimpton WG, Fraser JR, Laurent TC, Laurent GJ. Heterogeneity of type III procollagen N-terminal peptides in BAL fluid from normal and fibrotic lungs. Eur Respir J 1993; 6: 1443-1448.