IIAGlc inhibition of glycerol kinase: A communications network tunes protein motions at the allosteric site

Biochemistry

Volumn 46, Issue 43, 2007, Pages 12355-12365

  Yu, Peng ^a,b   Lasagna, Mauricio ^a   Pawlyk, Aaron C ^a,c   Reinhart, Gregory D ^a   Pettigrew, Donald W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC COMMUNICATION NETWORKS; ALLOSTERIC SITES; FLUORESCENCE ANISOTROPY; GLYCEROL KINASE;

AMINO ACIDS; BINDING SITES; CONFORMATIONS; CRYSTAL STRUCTURE; ESCHERICHIA COLI; FLUOROPHORES; GLYCEROL;

ENZYME INHIBITION;

2',7' DIFLUOROFLUORESCEIN; BACTERIAL ENZYME; FLUORESCEIN DERIVATIVE; GLYCEROL KINASE; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; PHOSPHOENOLPYRUVATE GLUCOSE PHOSPHOCARRIER PROTEIN, E COLI; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE; PHOSPHOENOLPYRUVATE-GLUCOSE PHOSPHOCARRIER PROTEIN, E COLI;

ALLOSTERISM; ANISOTROPY; ARTICLE; CHIMERA; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; ESCHERICHIA COLI; FLUORESCENCE ANALYSIS; HAEMOPHILUS INFLUENZAE; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; KINETICS; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE;

ALLOSTERIC SITE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCEROL KINASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHOENOLPYRUVATE SUGAR PHOSPHOTRANSFERASE SYSTEM;

EID: 35648965627     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7010948     Document Type: Article

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