FXR-deficiency confers increased susceptibility to torpor

FEBS Letters

Volumn 581, Issue 27, 2007, Pages 5191-5198

  Cariou, Bertrand ^a,b,c   Bouchaert, Emmanuel ^a,b,c   Abdelkarim, Mouaadh ^a,b,c   Dumont, Julie ^a,b,c   Caron, Sandrine ^a,b,c   Fruchart, Jean Charles ^a,b,c   Burcelin, Rémy ^b   Kuipers, Folkert ^d   Staels, Bart ^a,b,c  

^a INSTITUT PASTEUR DE LILLE   (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Cold exposure; Fasting; Nuclear receptor; Thermogenesis

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; GLUCOSE; LEPTIN; MESSENGER RNA; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY EXPENDITURE; ENERGY METABOLISM; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; STUPOR; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL;

MUS;

EID: 35648962885     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.09.064     Document Type: Article

References (23)

1. Cariou B., and Staels B. FXR: a promising target for the metabolic syndrome?. Trends Pharmacol. Sci. 28 (2007) 236-243
2. Kalaany N.Y., and Mangelsdorf D.J. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68 (2006) 159-191 159-191
3. Lowell B.B., and Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 404 (2000) 652-660
4. Watanabe M., Houten S.M., Mataki C., Christoffolete M.A., Kim B.W., Sato H., Messaddeq N., Harney J.W., Ezaki O., Kodama T., Schoonjans K., Bianco A.C., and Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439 (2006) 484-489
5. Sinal C.J., Tohkin M., Miyata M., Ward J.M., Lambert G., and Gonzalez F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102 (2000) 731-744
6. Kok T., Hulzebos C.V., Wolters H., Havinga R., Agellon L.B., Stellaard F., Shan B., Schwarz M., and Kuipers F. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J. Biol. Chem. 278 (2003) 41930-41937
7. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
8. Cariou B., van H.K., Duran-Sandoval D., van Dijk T.H., Grefhorst A., Abdelkarim M., Caron S., Torpier G., Fruchart J.C., Gonzalez F.J., Kuipers F., and Staels B. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J. Biol. Chem. 281 (2006) 11039-11049
9. Kawamata Y., Fujii R., Hosoya M., Harada M., Yoshida H., Miwa M., Fukusumi S., Habata Y., Itoh T., Shintani Y., Hinuma S., Fujisawa Y., and Fujino M. A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278 (2003) 9435-9440
10. Sivitz W.I., Fink B.D., and Donohoue P.A. Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140 (1999) 1511-1519
11. Cariou B., van H.K., Duran-Sandoval D., van D.T., Grefhorst A., Bouchaert E., Fruchart J.C., Gonzalez F.J., Kuipers F., and Staels B. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett. 579 (2005) 4076-4080
12. Ma K., Saha P.K., Chan L., and Moore D.D. Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest. 116 (2006) 1102-1109
13. Commins S.P., Watson P.M., Padgett M.A., Dudley A., Argyropoulos G., and Gettys T.W. Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 140 (1999) 292-300
14. Lee S.H., Dobrzyn A., Dobrzyn P., Rahman S.M., Miyazaki M., and Ntambi J.M. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J. Lipid Res. 45 (2004) 1674-1682
15. Kobayashi M., Ikegami H., Fujisawa T., Nojima K., Kawabata Y., Noso S., Babaya N., Itoi-Babaya M., Yamaji K., Hiromine Y., Shibata M., and Ogihara T. Prevention and treatment of obesity, insulin resistance, and diabetes by bile Acid-binding resin. Diabetes 56 (2007) 239-247
16. Freinkel N., Metzger B.E., Harris E., Robinson S., and Mager M. The hypothermia of hypoglycemia. Studies with 2-deoxy-d-glucose in normal human subjects and mice. N. Engl. J. Med. 287 (1972) 841-845
17. Webb G.P., Jagot S.A., and Jakobson M.E. Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies. Comp. Biochem. Physiol. A 72 (1982) 211-219
18. Gavrilova O., Leon L.R., Marcus-Samuels B., Mason M.M., Castle A.L., Refetoff S., Vinson C., and Reitman M.L. Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. USA 96 (1999) 14623-14628
19. Moitra J., Mason M.M., Olive M., Krylov D., Gavrilova O., Marcus-Samuels B., Feigenbaum L., Lee E., Aoyama T., Eckhaus M., Reitman M.L., and Vinson C. Life without white fat: a transgenic mouse. Genes Dev. 12 (1998) 3168-3181
20. Bachman E.S., Dhillon H., Zhang C.Y., Cinti S., Bianco A.C., Kobilka B.K., and Lowell B.B. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297 (2002) 843-845
21. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 20 (1998) 92 829-839
22. Carmona M.C., Hondares E., Rodriguez de la Concepcion M.L., Rodriguez-Sureda V., Peinado-Onsurbe J., Poli V., Iglesias R., Villarroya F., and Giralt M. Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta. Biochem. J. 389 (2005) 47-56
23. Rizzo G., Disante M., Mencarelli A., Renga B., Gioiello A., Pellicciari R., and Fiorucci S. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Mol. Pharmacol. 70 (2006) 1164-1173