Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation

Nephrology Dialysis Transplantation

Volumn 11, Issue 3, 1996, Pages 514-520

  Nabokov, A ^a   Amann, K ^a   Wagner, J ^a   Gehlen, F ^a   Munter K ^b   Ritz, E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Knoll AG   (Germany)

Author keywords

Endothelin receptor antagonist; Glomerular hypertrophy; Glomerulosclerosis; Renal failure; Subtotal nephrectomy

Indexed keywords

4 TERT BUTYL N [6 (2 HYDROXYETHOXY) 5 (3 METHOXYPHENOXY) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; MESSENGER RNA; TRANDOLAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DRUG MECHANISM; GLOMERULOSCLEROSIS; KIDNEY INJURY; KIDNEY PERFUSION; KIDNEY SCAR; KIDNEY SURGERY; MALE; NEPHRECTOMY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0029974496     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/11.3.514     Document Type: Article

References (34)

1. Benigni A, Perico N, Gaspari F et al. Increased renal endothelin production in rats with reduced renal mass. Am J Physiol 1991; 260: F331-F339
2. Brooks DP, Contino LC, Storer B, Ohlstein EH. Increased endothelin excretion in rats with renal failure induced by partial nephrectomy. Br J Pharmacol 1991; 104: 987-989
3. Ohta K, Hirata Y, Shichiri M, et al. Urinary excretion of endothelin-1 in normal subjects and patients with renal disease. Kidney Int 1991; 39: 307-311
4. Worgall S, Manz F, Kleschin K, Feth R, Rascher W: Elevated urinary excretion of endothelin-like immunoreactivity in children with renal disease is related to urine flow rate. Clin Nephrol 1994; 41: 331-337
5. Takeda M, Komeyama T, Tsutsui T, Mizusawa T, Katayama Y, GoH, Tamaki M, Gatano A. Changes in urinary excretion of endothelin1-like immunoreactivity before and after unilateral nephrectomy in humans. Nephron 1994; 67: 180-184
6. Torralbo A, Trobo JL, Borque M et al. Alterations in renal endothelin production in rats with reduced renal mass. Am J Kidney Dis 1995; 25: 918-923
7. Saito Y, Kazuwa N, Shirakami G et al. Endothelin in patients with chronic renal failure. J Cardiovasc Pharmacol 1991; 17 [Suppl 7]: S437-S439
8. Orisio S, Benigni A, Bruzzi I et al. Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. Kidney Int 1993; 43: 354-358
9. Inui K, Yoshimura A, Iwasaki S, Ideura T, Koshikawa S. Enhanced expression of endothelin-1 (ET-1) protein, preproET-1 mRNA and endothelin B type receptor in glomeruli of the remnant kidney. J Am Soc Nephrol 1992; 3: 438 [Abstract]
10. Osada S, Nakamura T, Ebihara I, Suzuki S, Tomino Y, Koide H. Endothelin gene expression in glomeruli and medulla from focal glomerulosclerosis. J Am Soc Nephrol 1991; 2: 412 [Abstract]
11. Benigni A, Zoja K, Corna D, Orisio S, Remuzzi G. Role of renal endothelin type B receptor in experimental progressive renal disease. J Am Soc Nephrol 1994; 5: 573 [Abstract]
12. Luk JKH, Wong EFC, Wong NLM. Downregulation of endothelin B receptors in chronic renal failure glomeruli. J Am Soc Nephrol 1994; 5: 949 [Abstract]
13. Benigni A, Zoja C, Corna D et al. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int 1993; 44: 440-444
14. Nakamura T, Ebihara I, Tomino Y, Koide H. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis. Kidney Int 1995; 47: 481-489
15. Koide H, Nakamura T, Ebihara I, Fukui M. Endothelins in diabetic kidneys. Kidney Int 1995; 48 [Suppl. 51]: S45-S49
16. B receptor antagonist ameliorates renal function and prolongs survival in remnant kidney rats. In: XIIIth International Congress of Nephrology. Abstracts International Society of Nephrology, Madrid 1995; 304a
17. Kleinknecht C, Terzi F, Burtin M, Laouari D, Maniar S. Experimental models of nephron reduction: Some answers, many questions. Kidney Int 1995; 47 [Suppl. 49]: S51-S54
18. B] mediates auto-induction of endothelin-1 [ET-I]. J Am Soc Nephrol 1994; 5: 717 [Abstract]
19. Amann K, Irzyniec T, Mall G, Ritz E. The effect of enalapril on glomerular growth and glomerular lesions after subtotal nephrectomy in the rat: a stereological analysis. J Hypertension 1993; 11: 969-975
20. Freedlender AE, Goodfriend TL. Renin and the angiotensins. In: Jaffe BM, Behrman HR eds. Methods of Hormone Radioimmunoassay. 2. A. Academic Press, New York, 1979; 889-907
21. El Nahas AM, Bassett AH, Cope GH, Le Carpentier JE. Role of growth hormone in the development of experimental renal scarring. Kidney Int 1991; 40: 29-34
22. Véniant M, Heudes D, Clozel JP, Bruneval P, Ménard J: Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats. Kidney Int 1994; 46: 421-429
23. Weibel ER. Stereological methods. Vol 1. Practical methods for biological morphometry. Academic Press, London, 1979
24. Weibel ER. Stereological methods. Vol. 2. Theoretical foundations. Academic Press, London, 1979; 144-152
25. Liefeldt L, Böcker W, Schönfelder G, Zintz M, Paul M. Regulation of the endothelin system in transgenic rats expressing the human endothelin-2 gene. J Cardiovasc Pharmacol 1995; 26: [Suppl. 3]: S32-S33
26. Paul M, Wagner J, Dzau VJ. Gene expression of the renin-angiotensin system in human tissues: quantitative analysis by the polymerase chain reaction. J Clin Invest 1993; 91: 2058-2064
27. Bidani AK, Griffin KA, Picken M, Lansky DM. Continuous telemetric blood pressure monitoring and glomerular injury in the rat remnant kidney model. Am J Physiol 1993; 265: F391-398
28. Zoja C, Morigi M, Figliuzzi M, Bruzzi I, Benigni A, Ronco PM, Remuzzi G. The renal toxicity of filtered proteins: evidence that albumin stimulates endothelin-1 [ET-1] synthesis by proximal tubular epithelial cells in culture. J Am Soc Nephrol 1993; 4: 789 [Abstract]
29. Ong ACM. Tubulointerstitial action of endothelins in the kidney: Roles in health and disease. Nephrol Dial Transplant 1996 (in press)
30. Simonson MS, Dunn MJ. Renal actions of endothelin peptides. Curr Opin Nephrol Hypertens 1993; 2: 51-60
31. Pollock DM, Opgenorth TY. Evidence for endothelin-induced renal vasoconstriction independent of ETA receptor activation. Am J Physiol 1993; 264. R222-R226
32. Wellings RP, Corder R, Doherty AM, Vane JR. Antagonism of renal and systemic responses to endothelin-1 infusion with PD 14565. Eur J Pharmacol 1994; 256: 201-204
33. Pernow J, Boutier JF, Franco-Cereceda A, Lacroix JS, Matran R, Lundberg JM. Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo. Acta Physiol Scand 1988; 134: 573-574
34. - exchange, c-fos expression, and mitogenesis in rat mesangial cells. J Clin Invest 1989; 83: 708-712