La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity

Life Sciences

Volumn 81, Issue 19-20, 2007, Pages 1461-1466

  Huang, Mingguo ^a   Ida, Hiroaki ^a   Arima, Kazuhiko ^a   Nakamura, Hideki ^a   Aramaki, Toshiyuki ^a   Fujikawa, Keita ^a   Tamai, Mami ^a   Kamachi, Makoto ^a   Kawakami, Atsushi ^a   Yamasaki, Hironori ^b   Origuchi, Tomoki ^b   Eguchi, Katsumi ^a  

^a Graduate School of Biomedical Sciences   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Granzyme B; La (SS B); Translocation

Indexed keywords

AUTOANTIBODY; GRANZYME B; GREEN FLUORESCENT PROTEIN; LA ANTIGEN;

AMINO TERMINAL SEQUENCE; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SALIVARY GLAND; SJOEGREN SYNDROME;

AUTOANTIGENS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; GRANZYMES; GREEN FLUORESCENT PROTEINS; HUMANS; MICROSCOPY, CONFOCAL; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; RIBONUCLEOPROTEINS; TRANSFECTION;

EID: 35549007095     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.09.017     Document Type: Article

References (26)

1. Ayukawa K., Taniguchi S., Masumoto J., Hashimoto S., Sarvotham H., Hara A., Aoyama T., and Sagara J. La autoantigen is cleaved in the COOH terminus and loses the nuclear localization signal during apoptosis. Journal of Biological Chemistry 275 (2000) 34465-34470
2. Barcellos K.S., Nonogaki S., Enokihara M.M., Teixeira M.S., and Andrade L.E. Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome. Journal of Rheumatology 34 (2007) 1283-1292
3. Casciola-Rosen L.A., Anhalt G., and Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. Journal of Experimental Medicine 179 (1994) 1317-1330
4. Casciola-Rosen L., Andrade F., Ulanet D., Wong W.B., and Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. Journal of Experimental Medicine 190 (1999) 815-826
5. Golan T.D., Elkon K.B., Gharavi A.E., and Krueger J.G. Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation. Journal of Clinical Investigation 90 (1992) 1067-1076
6. Greidinger E.L., Foecking M.F., Ranatunga S., and Hoffman R.W. Apoptotic U1-70 kD is antigenically distinct from the intact form of the U1-70-kd molecule. Arthritis and Rheumatism 46 (2002) 1264-1269
7. Huang M., Ida H., Kamachi M., Iwanaga N., Izumi Y., Tanaka F., Aratake K., Arima K., Tamai M., Hida A., Nakamura H., Origuchi T., Kawakami A., Ogawa N., Sugai S., Utz P.J., and Eguchi K. Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome. Clinical and Experimental Immunology 142 (2005) 148-154
8. Ida H., Nakashima T., Kedersha N.L., Yamasaki S., Huang M., Izumi Y., Miyashita T., Origuchi T., Kawakami A., Migita K., Bird P.I., Anderson P., and Eguchi K. Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death. European Journal of Immunology 33 (2003) 3284-3292
9. Ida H., Utz P.J., Anderson P., and Eguchi K. Granzyme B and natural killer (NK) cell death. Modern Rheumatology 15 (2005) 315-322
10. LeFeber W.P., Norris D.A., Ryan S.R., Huff J.C., Lee L.A., Kubo M., Boyce S.T., Kotzin B.L., and Weston W.L. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. Journal of Clinical Investigation 74 (1984) 1545-1551
11. Lord S.J., Rajotte R.V., Korbutt G.S., and Bleackley R.C. Granzyme B: a natural born killer. Immunological Reviews 193 (2003) 31-38
12. Martin S.J., Newmeyer D.D., Mathias S., Farschon D.M., Wang H.G., Reed J.C., Kolesnick R.N., and Green D.R. Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis. Embo Journal 14 (1995) 5191-5200
13. Martin S.J., Amarante-Mendes G.P., Shi L., Chuang T.H., Casiano C.A., O'Brien G.A., Fitzgerald P., Tan E.M., Bokoch G.M., Greenberg A.H., and Green D.R. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. Embo Journal 15 (1996) 2407-2416
14. Moutsopoulos H.M., Chused T.M., Mann D.L., Klippel J.H., Fauci A.S., Frank M.M., Lawley T.J., and Hamburger M.I. Sjögren's syndrome (Sicca syndrome): current issues. Annals of Internal Medicine 92 (1980) 212-226
15. Neufing P.J., Clancy R.M., Jackson M.W., Tran H.B., Buyon J.P., and Gordon T.P. Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells. Arthritis and Rheumatism 52 (2005) 3934-3942
16. Pruijn G.J., Slobbe R.L., and van Venrooij W.J. Analysis of protein-RNA interactions within Ro ribonucleoprotein complexes. Nucleic Acids Research 19 (1991) 5173-5180
17. Pruijn G.J., Thijssen J.P., Smith P.R., Williams D.G., and Van Venrooij W.J. Anti-La monoclonal antibodies recognizing epitopes within the RNA-binding domain of the La protein show differential capacities to immunoprecipitate RNA-associated La protein. European Journal of Biochemistry 232 (1995) 611-619
18. Reed J.H., Neufing P.J., Jackson M.W., Clancy R.M., Macardle P.J., Buyon J.P., and Gordon T.P. Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes. Clinical and Experimental Immunology 148 (2007) 153-160
19. Rosen A., and Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death and Differentiation 6 (1999) 6-12
20. Rutjes S.A., Utz P.J., van der Heijden A., Broekhuis C., van Venrooij W.J., and Pruijn G.J. The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death and Differentiation 6 (1999) 976-986
21. Schachna L., Wigley F.M., Morris S., Gelber A.C., Rosen A., and Casciola-Rosen L. Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss. Arthritis and Rheumatism 46 (2002) 1873-1884
22. Trapani J.A., Davis J., Sutton V.R., and Smyth M.J. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Current Opinion in Immunology 12 (2000) 323-329
23. Utz P.J., and Anderson P. Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens. Arthritis and Rheumatism 41 (1998) 1152-1160
24. Utz P.J., Gensler T.J., and Anderson P. Death, autoantigen modifications, and tolerance. Arthritis Research 2 (2000) 101-114
25. Vitali C., Moutsopoulos H.M., and Bombardieri S. The European Community Study Group on diagnostic criteria for Sjögren's syndrome. Sensitivity and specificity of tests for ocular and oral involvement in Sjogren's syndrome. Annals of Rheumatic Disease 53 (1994) 637-647
26. Wolin S.L., and Cedervall T. The La protein. Annual Review of Biochemistry 71 (2002) 375-403