The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data

Journal of Pharmaceutical and Biomedical Analysis

Volumn 45, Issue 4, 2007, Pages 552-564

  Meloun, Milan ^a   Bordovská, Sylva ^a   Galla, Lubomír ^b  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b Bochemie as   (Czech Republic)

Author keywords

ACD pKa; Diclofenac sodium; Dissociation constant; Flurbiprofen; Ibuprofen; INDICES; Ketoprofen; MARVIN; Non steroidal anti inflammatory drugs (NSAIDs); PALLAS; Pharma Algorithms; Protonation; SPARC; SPECFIT; Spectrophotometric titration; SQUAD

Indexed keywords

DICLOFENAC; FLURBIPROFEN; IBUPROFEN; KETOPROFEN;

ALGORITHM; ARTICLE; COMPUTER PROGRAM; DISSOCIATION CONSTANT; DRUG STRUCTURE; FACTORIAL ANALYSIS; IONIC STRENGTH; LOW TEMPERATURE; MULTIWAVELENGTH SPECTROPHOTOMETRY; NONLINEAR REGRESSION ANALYSIS; PKA; PREDICTION; PRIORITY JOURNAL; PROTON TRANSPORT; REGRESSION ANALYSIS; RELIABILITY; SPECTROPHOTOMETRY; THERMODYNAMICS; TITRIMETRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HYDROGEN-ION CONCENTRATION; LEAST-SQUARES ANALYSIS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NONLINEAR DYNAMICS; SOLUBILITY; SPECTROPHOTOMETRY; THERMODYNAMICS; TITRIMETRY;

EID: 35548972070     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.07.029     Document Type: Article

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