Chromatographic determination of aqueous dissociation constants of some water-insoluble nonsteroidal antiinflammatory drugs

Journal of Pharmaceutical Sciences

Volumn 91, Issue 4, 2002, Pages 991-999

  Oumada, Fadoua Z ^a   Raand̀fols, Clara ^a   Roseand́s, Martiand́ ^a   Bosch, Elisabeth ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Aqueous pK; HPLC; Nonsteroidal antiinflammatory drugs

Indexed keywords

BUFFER; BUTIBUFEN; DICLOFENAC; FENBUFEN; FLURBIPROFEN; IBUPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ACCURACY; ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; DISSOCIATION CONSTANT; DRUG DETERMINATION; DRUG SOLUBILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PKA; VALIDATION PROCESS;

EID: 0036279837     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10096     Document Type: Article

References (31)

1. a values of medicinal compounds in pharmacy practice
2. Die dissoziation der schwachen electrolyse in wasserig-alkoholischen losungen
3. a determination of water-insoluble compounds: Validation study in methanol-water mixtures
4. Retention of ionizable compounds on HPLC. 4. Mobile-phase pH measurements in methanol-water
5. Retention of ionizable compounds on HPLC. 6. pH measurements with the glass electrode in methanol-water mixtures
6. Retention of ionizable compounds on HPLC. 5. pH scales and the retention of acids and bases with acetonitrile-water mobile phases
7. 18 columns
8. Variation of acidity constants and pH values of some organic acids in water-2-propanol mixtures with solvent composition. Effect of preferential solvation
9. Dissociation constants of several non steroidal anti-inflammatory drugs in isopropyl alcohol/water mixtures
10. Conductometric determination of dissociation constants of several acids and their tetrabutylammonium salts in propan-2-ol/water mixtures
11. Dissociation constants of phenols in methanol-water mixtures
12. Effect of solvation of ions and molecules on acid dissociation
13. Dissociation constants of neutral and charged acids in methyl alcohol. The acid strength resolution
14. pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances
15. Acidity in methanol-water
16. Retention of ionizable compounds on HPLC. pH scale in methanol-water and the pK and pH values of buffers
17. Retention of ionizable compounds on HPLC. 2. Effect of the pH, ionic strength and mobile phase composition on the retention of weak acids
18. Dissociation constants of some anti-inflammatory agents (αphenylpropionic acids) in isopropyl and tert-butyl alcohol media
19. a values of several non-steroidal anti-inflammatory drugs
20. Acidity constants of sparingly water-soluble drugs from potentiometric determinations in aqueous dimethyl sulfoxide
21. Ionization constants of water insoluble arylpropionic acids in aqueous N,N-dimethylformamide mixtures from potentiometric pH-titrations
22. Prediction of skin permeabilities of diclofenac and propanolol form theoretical partition coefficients determined from cohesion parameters
23. pH-solubility relationship and partition coefficients for some anti-inflammatory arylaliphatic acids
24. a's
25. Dissociation constants, solubilities and dissolution rates of some selected nonsteroidal antiinflammatories