Astrocytes in Huntington's chorea: Accomplice or guilty of the neuronal death?;Les astrocytes dans la chorée de Huntington: Complices ou coupables de la mort neuronale?

Medecine/Sciences

Volumn 23, Issue 10, 2007, Pages 845-849

  Liévens, Jean Charles ^a   Birman, Serge ^a,b  

^a CNRS   (France)

^b Mediterranée University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ASTROCYTE; HUMAN; HUNTINGTON CHOREA; MUTATION; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE CELL NECROSIS; REVIEW;

EID: 35548957787     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20072310845     Document Type: Review

References (26)

1. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993 ; 72 : 971-83.
2. Liévens JC, Birman S. La chorée de Huntington chez la drosophile et chez la souris: vers de nouvelles pistes thérapeutiques ? Med Sci (Paris) 2003 ; 19 : 593-9.
3. Chneiweiss H. Les astrocytes contrôlent la neurogenèse dans le système nerveux central. Med Sci (Paris) 2002 ; 18 : 1065-6.
4. Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 2005 ; 6 : 626-40.
5. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001 ; 65 : 1-105.
6. Matute C, Domercq M, Sanchez-Gomez MV. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 2006 ; 53 : 212-24.
7. Hansson E, Ronnback L. Glial neuronal signaling in the central nervous system. FASEB J 2003 ; 17 : 341-8.
8. Singhrao SK, Thomas P, Wood JD, et al. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. Exp Neurol 1998 ; 150 : 213-22.
9. Hebb MO, Denovan-Wright EM, Robertson HA. Expression of the Huntington's disease gene is regulated in astrocytes in the arcuate nucleus of the hypothalamus of postpartum rats. FASEB J 1999 ; 13 : 1099-106.
10. Shin JY, Fang ZH, Yu ZX, et al. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 2005 ; 171 : 1001-12.
11. Cross AJ, Slater P, Reynolds GP. Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease. Neurosci Lett 1986 ; 67 : 198-202.
12. Arzberger T, Krampfl K, Leimgruber S, Weindl A. Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease-an in situ hybridization study. J Neuropathol Exp Neurol 1997 ; 56 : 440-54.
13. Hermel E, Gafni J, Propp SS, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ 2004 ; 11 : 424-38.
14. Vis JC, Schipper E, de Boer-van Huizen RT, et al. Expression pattern of apoptosis-related markers in Huntington's disease. Acta Neuropathol (Berl) 2005 ; 109 : 321-8.
15. Lievens JC, Woodman B, Mahal A, et al. Impaired glutamate uptake in the R6 Huntington's disease transgenic mice. Neurobiol Dis 2001 ; 8 : 807-21.
16. Behrens PF, Franz P, Woodman B, et al. Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 2002 ; 125 : 1908-22.
17. Nicniocaill B, Haraldsson B, Hansson O, et al. Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice. Eur J Neurosci 2001 ; 13 : 206-10.
18. Rival T, Soustelle L, Strambi C, et al. Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain. Curr Biol 2004 ; 14 : 599-605.
19. Liévens JC, Rival T, Iche M, Chneiweiss H, Birman S. Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila. Hum Mol Genet 2005 ; 14 : 713-24.
20. Kretzschmar D, Tschape J, Bettencourt Da Cruz A, et al. Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila. Glia 2005 ; 49 : 59-72.
21. Custer SK, Garden GA, Gill N, et al. Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci 2006 ; 9 : 1302-11.
22. Junier MP. What role(s) for TGFalpha in the central nervous system? Prog Neurobiol 2000 ; 62 : 443-73.
23. Figiel M, Maucher T, Rozyczka J, et al. Regulation of glial glutamate transporter expression by growth factors. Exp Neurol 2003 ; 183 : 124-35.
24. Song C, Perides G, Liu YF. Expression of full-length polyglutamine- expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells. J Biol Chem 2002 ; 277 : 6703-7.
25. Li SH, Yu ZX, Li CL, et al. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci 2003 ; 23 : 6956-64.
26. Bradley SV, Holland EC, Liu GY, et al. Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. Cancer Res 2007 ; 67 : 3609-15.